3E8C

Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001669	cellular_component	acrosomal vesicle
A	0001707	biological_process	mesoderm formation
A	0001843	biological_process	neural tube closure
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004691	molecular_function	cAMP-dependent protein kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005930	cellular_component	axoneme
A	0005952	cellular_component	cAMP-dependent protein kinase complex
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0006611	biological_process	protein export from nucleus
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0030145	molecular_function	manganese ion binding
A	0031594	cellular_component	neuromuscular junction
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034605	biological_process	cellular response to heat
A	0036126	cellular_component	sperm flagellum
A	0044853	cellular_component	plasma membrane raft
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0045667	biological_process	regulation of osteoblast differentiation
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0048240	biological_process	sperm capacitation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050766	biological_process	positive regulation of phagocytosis
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0051726	biological_process	regulation of cell cycle
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070417	biological_process	cellular response to cold
A	0070613	biological_process	regulation of protein processing
A	0071333	biological_process	cellular response to glucose stimulus
A	0071374	biological_process	cellular response to parathyroid hormone stimulus
A	0071377	biological_process	cellular response to glucagon stimulus
A	0097546	cellular_component	ciliary base
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
A	0106310	molecular_function	protein serine kinase activity
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
A	1990044	biological_process	protein localization to lipid droplet
A	2000810	biological_process	regulation of bicellular tight junction assembly
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001669	cellular_component	acrosomal vesicle
B	0001707	biological_process	mesoderm formation
B	0001843	biological_process	neural tube closure
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004691	molecular_function	cAMP-dependent protein kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005930	cellular_component	axoneme
B	0005952	cellular_component	cAMP-dependent protein kinase complex
B	0006397	biological_process	mRNA processing
B	0006468	biological_process	protein phosphorylation
B	0006611	biological_process	protein export from nucleus
B	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
B	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0018105	biological_process	peptidyl-serine phosphorylation
B	0019901	molecular_function	protein kinase binding
B	0019904	molecular_function	protein domain specific binding
B	0030007	biological_process	intracellular potassium ion homeostasis
B	0030145	molecular_function	manganese ion binding
B	0031594	cellular_component	neuromuscular junction
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032024	biological_process	positive regulation of insulin secretion
B	0034237	molecular_function	protein kinase A regulatory subunit binding
B	0034605	biological_process	cellular response to heat
B	0036126	cellular_component	sperm flagellum
B	0044853	cellular_component	plasma membrane raft
B	0045542	biological_process	positive regulation of cholesterol biosynthetic process
B	0045667	biological_process	regulation of osteoblast differentiation
B	0045722	biological_process	positive regulation of gluconeogenesis
B	0045879	biological_process	negative regulation of smoothened signaling pathway
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0048240	biological_process	sperm capacitation
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050766	biological_process	positive regulation of phagocytosis
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0051726	biological_process	regulation of cell cycle
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070417	biological_process	cellular response to cold
B	0070613	biological_process	regulation of protein processing
B	0071333	biological_process	cellular response to glucose stimulus
B	0071374	biological_process	cellular response to parathyroid hormone stimulus
B	0071377	biological_process	cellular response to glucagon stimulus
B	0097546	cellular_component	ciliary base
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
B	0106310	molecular_function	protein serine kinase activity
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
B	1990044	biological_process	protein localization to lipid droplet
B	2000810	biological_process	regulation of bicellular tight junction assembly
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001669	cellular_component	acrosomal vesicle
C	0001707	biological_process	mesoderm formation
C	0001843	biological_process	neural tube closure
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004691	molecular_function	cAMP-dependent protein kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005930	cellular_component	axoneme
C	0005952	cellular_component	cAMP-dependent protein kinase complex
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0006611	biological_process	protein export from nucleus
C	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
C	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0030007	biological_process	intracellular potassium ion homeostasis
C	0030145	molecular_function	manganese ion binding
C	0031594	cellular_component	neuromuscular junction
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032024	biological_process	positive regulation of insulin secretion
C	0034237	molecular_function	protein kinase A regulatory subunit binding
C	0034605	biological_process	cellular response to heat
C	0036126	cellular_component	sperm flagellum
C	0044853	cellular_component	plasma membrane raft
C	0045542	biological_process	positive regulation of cholesterol biosynthetic process
C	0045667	biological_process	regulation of osteoblast differentiation
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045879	biological_process	negative regulation of smoothened signaling pathway
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0048240	biological_process	sperm capacitation
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050766	biological_process	positive regulation of phagocytosis
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0051726	biological_process	regulation of cell cycle
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070417	biological_process	cellular response to cold
C	0070613	biological_process	regulation of protein processing
C	0071333	biological_process	cellular response to glucose stimulus
C	0071374	biological_process	cellular response to parathyroid hormone stimulus
C	0071377	biological_process	cellular response to glucagon stimulus
C	0097546	cellular_component	ciliary base
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
C	0106310	molecular_function	protein serine kinase activity
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
C	1990044	biological_process	protein localization to lipid droplet
C	2000810	biological_process	regulation of bicellular tight junction assembly
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001669	cellular_component	acrosomal vesicle
D	0001707	biological_process	mesoderm formation
D	0001843	biological_process	neural tube closure
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004691	molecular_function	cAMP-dependent protein kinase activity
D	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005930	cellular_component	axoneme
D	0005952	cellular_component	cAMP-dependent protein kinase complex
D	0006397	biological_process	mRNA processing
D	0006468	biological_process	protein phosphorylation
D	0006611	biological_process	protein export from nucleus
D	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
D	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0018105	biological_process	peptidyl-serine phosphorylation
D	0019901	molecular_function	protein kinase binding
D	0019904	molecular_function	protein domain specific binding
D	0030007	biological_process	intracellular potassium ion homeostasis
D	0030145	molecular_function	manganese ion binding
D	0031594	cellular_component	neuromuscular junction
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032024	biological_process	positive regulation of insulin secretion
D	0034237	molecular_function	protein kinase A regulatory subunit binding
D	0034605	biological_process	cellular response to heat
D	0036126	cellular_component	sperm flagellum
D	0044853	cellular_component	plasma membrane raft
D	0045542	biological_process	positive regulation of cholesterol biosynthetic process
D	0045667	biological_process	regulation of osteoblast differentiation
D	0045722	biological_process	positive regulation of gluconeogenesis
D	0045879	biological_process	negative regulation of smoothened signaling pathway
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0048240	biological_process	sperm capacitation
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050766	biological_process	positive regulation of phagocytosis
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0051726	biological_process	regulation of cell cycle
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070417	biological_process	cellular response to cold
D	0070613	biological_process	regulation of protein processing
D	0071333	biological_process	cellular response to glucose stimulus
D	0071374	biological_process	cellular response to parathyroid hormone stimulus
D	0071377	biological_process	cellular response to glucagon stimulus
D	0097546	cellular_component	ciliary base
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
D	0106310	molecular_function	protein serine kinase activity
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
D	1990044	biological_process	protein localization to lipid droplet
D	2000810	biological_process	regulation of bicellular tight junction assembly
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001669	cellular_component	acrosomal vesicle
E	0001707	biological_process	mesoderm formation
E	0001843	biological_process	neural tube closure
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004691	molecular_function	cAMP-dependent protein kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005930	cellular_component	axoneme
E	0005952	cellular_component	cAMP-dependent protein kinase complex
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0006611	biological_process	protein export from nucleus
E	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
E	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016607	cellular_component	nuclear speck
E	0016740	molecular_function	transferase activity
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030007	biological_process	intracellular potassium ion homeostasis
E	0030145	molecular_function	manganese ion binding
E	0031594	cellular_component	neuromuscular junction
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034605	biological_process	cellular response to heat
E	0036126	cellular_component	sperm flagellum
E	0044853	cellular_component	plasma membrane raft
E	0045542	biological_process	positive regulation of cholesterol biosynthetic process
E	0045667	biological_process	regulation of osteoblast differentiation
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0048240	biological_process	sperm capacitation
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050766	biological_process	positive regulation of phagocytosis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0051726	biological_process	regulation of cell cycle
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070417	biological_process	cellular response to cold
E	0070613	biological_process	regulation of protein processing
E	0071333	biological_process	cellular response to glucose stimulus
E	0071374	biological_process	cellular response to parathyroid hormone stimulus
E	0071377	biological_process	cellular response to glucagon stimulus
E	0097546	cellular_component	ciliary base
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
E	0106310	molecular_function	protein serine kinase activity
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	1990044	biological_process	protein localization to lipid droplet
E	2000810	biological_process	regulation of bicellular tight junction assembly
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001669	cellular_component	acrosomal vesicle
F	0001707	biological_process	mesoderm formation
F	0001843	biological_process	neural tube closure
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004691	molecular_function	cAMP-dependent protein kinase activity
F	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005930	cellular_component	axoneme
F	0005952	cellular_component	cAMP-dependent protein kinase complex
F	0006397	biological_process	mRNA processing
F	0006468	biological_process	protein phosphorylation
F	0006611	biological_process	protein export from nucleus
F	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
F	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016607	cellular_component	nuclear speck
F	0016740	molecular_function	transferase activity
F	0018105	biological_process	peptidyl-serine phosphorylation
F	0019901	molecular_function	protein kinase binding
F	0019904	molecular_function	protein domain specific binding
F	0030007	biological_process	intracellular potassium ion homeostasis
F	0030145	molecular_function	manganese ion binding
F	0031594	cellular_component	neuromuscular junction
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032024	biological_process	positive regulation of insulin secretion
F	0034237	molecular_function	protein kinase A regulatory subunit binding
F	0034605	biological_process	cellular response to heat
F	0036126	cellular_component	sperm flagellum
F	0044853	cellular_component	plasma membrane raft
F	0045542	biological_process	positive regulation of cholesterol biosynthetic process
F	0045667	biological_process	regulation of osteoblast differentiation
F	0045722	biological_process	positive regulation of gluconeogenesis
F	0045879	biological_process	negative regulation of smoothened signaling pathway
F	0046827	biological_process	positive regulation of protein export from nucleus
F	0048240	biological_process	sperm capacitation
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0050766	biological_process	positive regulation of phagocytosis
F	0050804	biological_process	modulation of chemical synaptic transmission
F	0051726	biological_process	regulation of cell cycle
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0070417	biological_process	cellular response to cold
F	0070613	biological_process	regulation of protein processing
F	0071333	biological_process	cellular response to glucose stimulus
F	0071374	biological_process	cellular response to parathyroid hormone stimulus
F	0071377	biological_process	cellular response to glucagon stimulus
F	0097546	cellular_component	ciliary base
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
F	0106310	molecular_function	protein serine kinase activity
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
F	1990044	biological_process	protein localization to lipid droplet
F	2000810	biological_process	regulation of bicellular tight junction assembly
G	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
G	0006469	biological_process	negative regulation of protein kinase activity
H	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
H	0006469	biological_process	negative regulation of protein kinase activity
I	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
I	0006469	biological_process	negative regulation of protein kinase activity
J	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
J	0006469	biological_process	negative regulation of protein kinase activity
K	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
K	0006469	biological_process	negative regulation of protein kinase activity
L	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
L	0006469	biological_process	negative regulation of protein kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE G96 A 351

Chain	Residue
A	LEU49
A	MET120
A	GLU121
A	TYR122
A	VAL123
A	LEU173
A	THR183
A	ASP184
A	PHE185
A	PHE327
A	GLY52
A	PHE54
A	GLY55
A	ARG56
A	LYS72
A	GLU91
A	LEU95
A	VAL104

---

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE G96 B 351

Chain	Residue
B	GLY50
B	GLY52
B	PHE54
B	GLY55
B	ARG56
B	VAL57
B	LYS72
B	LEU74
B	GLU91
B	LEU95
B	VAL104
B	MET120
B	GLU121
B	TYR122
B	VAL123
B	LEU173
B	THR183
B	ASP184
B	PHE185
B	PHE327
B	HOH706
B	HOH728
B	HOH752

---

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE G96 C 351

Chain	Residue
C	LEU49
C	PHE54
C	GLY55
C	ARG56
C	VAL57
C	LYS72
C	LEU74
C	GLU91
C	LEU95
C	VAL104
C	MET120
C	GLU121
C	TYR122
C	VAL123
C	LEU173
C	THR183
C	ASP184
C	PHE185
C	PHE327
C	HOH392

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE G96 D 351

Chain	Residue
D	LEU49
D	GLY50
D	GLY52
D	PHE54
D	GLY55
D	ARG56
D	VAL57
D	LYS72
D	LEU74
D	GLU91
D	LEU95
D	VAL104
D	MET120
D	GLU121
D	TYR122
D	VAL123
D	LEU173
D	THR183
D	ASP184
D	PHE185
D	PHE327
D	HOH389

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE G96 E 351

Chain	Residue
E	THR183
E	ASP184
E	PHE185
E	PHE327
E	LEU49
E	GLY52
E	PHE54
E	GLY55
E	ARG56
E	VAL57
E	LYS72
E	LEU74
E	GLU91
E	LEU95
E	VAL104
E	MET120
E	GLU121
E	TYR122
E	VAL123
E	LEU173

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE G96 F 351

Chain	Residue
F	LEU49
F	PHE54
F	GLY55
F	ARG56
F	VAL57
F	LYS72
F	LEU74
F	GLU91
F	LEU95
F	VAL104
F	MET120
F	GLU121
F	TYR122
F	VAL123
F	LEU173
F	THR183
F	ASP184
F	PHE185
F	PHE327
F	HOH397

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhmetgnh..........YAMK

Chain	Residue	Details
A	LEU49-LYS72

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI

Chain	Residue	Details
A	LEU162-ILE174

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	SITE: Important for inhibition => ECO:0000250

Chain	Residue	Details
G	ARG15
J	ARG15
J	ARG18
J	ARG19
K	ARG15
K	ARG18
K	ARG19
L	ARG15
L	ARG18
L	ARG19
G	ARG18
G	ARG19
H	ARG15
H	ARG18
H	ARG19
I	ARG15
I	ARG18
I	ARG19

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LEU49
E	LYS72
F	LEU49
F	LYS72
A	LYS72
B	LEU49
B	LYS72
C	LEU49
C	LYS72
D	LEU49
D	LYS72
E	LEU49

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	GLU121
E	LYS168
F	GLU121
F	LYS168
A	LYS168
B	GLU121
B	LYS168
C	GLU121
C	LYS168
D	GLU121
D	LYS168
E	GLU121

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:10684253, ECO:0000269|PubMed:11152138, ECO:0000269|PubMed:9521123

Chain	Residue	Details
A	ASN2
B	ASN2
C	ASN2
D	ASN2
E	ASN2
F	ASN2

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P05132

Chain	Residue	Details
A	SEP10
B	SEP10
C	SEP10
D	SEP10
E	SEP10
F	SEP10

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612

Chain	Residue	Details
A	THR48
E	THR195
F	THR48
F	THR195
A	THR195
B	THR48
B	THR195
C	THR48
C	THR195
D	THR48
D	THR195
E	THR48

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132

Chain	Residue	Details
A	SER139
B	SER139
C	SER139
D	SER139
E	SER139
F	SER139

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:6262777

Chain	Residue	Details
A	TPO197
B	TPO197
C	TPO197
D	TPO197
E	TPO197
F	TPO197

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132

Chain	Residue	Details
A	TYR330
B	TYR330
C	TYR330
D	TYR330
E	TYR330
F	TYR330

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:6262777

Chain	Residue	Details
A	SEP338
B	SEP338
C	SEP338
D	SEP338
E	SEP338
F	SEP338

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:6262777

Chain	Residue	Details
A	GLY1
B	GLY1
C	GLY1
D	GLY1
E	GLY1
F	GLY1

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	GLU170
A	ASP166

---

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP166
D	LYS168

---

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP166
E	LYS168

---

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP166
F	LYS168

---

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR201
A	ASP166
A	LYS168

---

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR201
B	ASP166
B	LYS168

---

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR201
C	ASP166
C	LYS168

---

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR201
D	ASP166
D	LYS168

---

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	THR201
E	ASP166
E	LYS168

---

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	THR201
F	ASP166
F	LYS168

---

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP166
A	ASN171
A	LYS168

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	GLU170
B	ASP166

---

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP166
B	ASN171
B	LYS168

---

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP166
C	ASN171
C	LYS168

---

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP166
D	ASN171
D	LYS168

---

site_id	CSA23
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP166
E	ASN171
E	LYS168

---

site_id	CSA24
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP166
F	ASN171
F	LYS168

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	GLU170
C	ASP166

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	GLU170
D	ASP166

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	GLU170
E	ASP166

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	GLU170
F	ASP166

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP166
A	LYS168

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP166
B	LYS168

---

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP166
C	LYS168

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
A	GLU170	activator, proton acceptor, proton donor
A	LEU172	electrostatic stabiliser, polar interaction
A	ASP175	metal ligand
A	ALA188	metal ligand
A	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
B	GLU170	activator, proton acceptor, proton donor
B	LEU172	electrostatic stabiliser, polar interaction
B	ASP175	metal ligand
B	ALA188	metal ligand
B	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA3
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
C	GLU170	activator, proton acceptor, proton donor
C	LEU172	electrostatic stabiliser, polar interaction
C	ASP175	metal ligand
C	ALA188	metal ligand
C	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA4
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
D	GLU170	activator, proton acceptor, proton donor
D	LEU172	electrostatic stabiliser, polar interaction
D	ASP175	metal ligand
D	ALA188	metal ligand
D	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA5
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
E	GLU170	activator, proton acceptor, proton donor
E	LEU172	electrostatic stabiliser, polar interaction
E	ASP175	metal ligand
E	ALA188	metal ligand
E	ILE209	electrostatic stabiliser, polar interaction

---

site_id	MCSA6
Number of Residues	5
Details	M-CSA 757

Chain	Residue	Details
F	GLU170	activator, proton acceptor, proton donor
F	LEU172	electrostatic stabiliser, polar interaction
F	ASP175	metal ligand
F	ALA188	metal ligand
F	ILE209	electrostatic stabiliser, polar interaction

---