3E87
Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RAC-beta serine/threonine-protein kinase | polymer | 335 | 39072.5 | 2 | UniProt (P31751) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | RAC-PK-beta, Protein kinase Akt-2, Protein kinase B, beta, PKB beta |
| 2 | C, D (C, D) | Glycogen synthase kinase-3 beta peptide | polymer | 10 | 1123.2 | 2 | UniProt (P49841) | GSK-3 beta | |
| 3 | E, F (A, B) | N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide | non-polymer | 362.4 | 2 | Chemie (G95) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A, B: 146 - 480 (UniProt: P31751)
| PDB | External Database | Details |
|---|---|---|
| Asp 474 | Ser 474 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 80391.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 724.9 | |
| All* | Total formula weight | 81116.4 |
