6X5V
| |
6X5W
| |
6X6Q
| |
2W7X
| Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019 | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, ... | 著者 | Jobson, A.G, Lountos, G.T, Lorenzi, P.L, Llamas, J, Connelly, J, Tropea, J.E, Onda, A, Kondapaka, S, Zhang, G, Caplen, N.J, Caredellina, J.H, Monks, A, Self, C, Waugh, D.S, Shoemaker, R.H, Pommier, Y. | 登録日 | 2009-01-06 | 公開日 | 2009-09-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019. J.Pharmacol.Exp.Ther., 331, 2009
|
|
2W2D
| Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A | 分子名称: | ACETATE ION, BOTULINUM NEUROTOXIN A HEAVY CHAIN, BOTULINUM NEUROTOXIN A LIGHT CHAIN, ... | 著者 | Masuyer, G, Thiyagarajan, N, James, P.L, Marks, P.M.H, Chaddock, J.A, Acharya, K.R. | 登録日 | 2008-10-29 | 公開日 | 2009-03-24 | 最終更新日 | 2022-05-04 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A. Biochem.Biophys.Res.Commun., 381, 2009
|
|
2VXH
| The crystal structure of chlorite dismutase: a detox enzyme producing molecular oxygen | 分子名称: | CARBONATE ION, CHLORITE DISMUTASE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | De Geus, D.C, Thomassen, E.A.J, Hagedoorn, P.L, Pannu, N.S, Abrahams, J.P. | 登録日 | 2008-07-04 | 公開日 | 2009-03-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of Chlorite Dismutase, a Detoxifying Enzyme Producing Molecular Oxygen J.Mol.Biol., 387, 2009
|
|
1B7J
| TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 V20A | 分子名称: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | 著者 | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | 登録日 | 1999-01-24 | 公開日 | 1999-04-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
|
|
1B7K
| TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 R47H | 分子名称: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | 著者 | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | 登録日 | 1999-01-24 | 公開日 | 1999-04-29 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
|
|
1B7I
| TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 K61R | 分子名称: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | 著者 | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | 登録日 | 1999-01-24 | 公開日 | 1999-04-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
|
|
1EKL
| TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 E35K | 分子名称: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | 著者 | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | 登録日 | 1999-01-21 | 公開日 | 1999-04-29 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
|
|
3DF9
| |
3DFL
| Crystal structure of human Prostasin complexed to 4-guanidinobenzoic acid | 分子名称: | 4-carbamimidamidobenzoic acid, Prostasin | 著者 | Su, H.P, Rickert, K.W, Darke, P.L, Munshi, S.K. | 登録日 | 2008-06-12 | 公開日 | 2008-10-14 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of human prostasin, a target for the regulation of hypertension. J.Biol.Chem., 283, 2008
|
|
3E8U
| Crystal structure and thermodynamic analysis of diagnostic Fab 106.3 complexed with BNP 5-13 (C10A) reveal basis of selective molecular recognition | 分子名称: | BNP peptide epitope, Fab 106.3 heavy chain, Fab 106.3 light chain | 著者 | Longenecker, K.L, Ruan, Q, Fry, E.H, Saldana, S.S, Brophy, S.E, Richardson, P.L, Tetin, S.Y. | 登録日 | 2008-08-20 | 公開日 | 2009-07-07 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A). Proteins, 76, 2009
|
|
3CQT
| N53I V55L MUTANT of FYN SH3 DOMAIN | 分子名称: | Proto-oncogene tyrosine-protein kinase Fyn | 著者 | Neculai, A.M, Zarrine-Afsar, A, Howell, P.L, Davidson, A, Chan, H.S. | 登録日 | 2008-04-03 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3DFJ
| Crystal structure of human Prostasin | 分子名称: | CHLORIDE ION, Prostasin | 著者 | Su, H.P, Rickert, K.W, Darke, P.L, Munshi, S.K. | 登録日 | 2008-06-12 | 公開日 | 2008-10-14 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure of human prostasin, a target for the regulation of hypertension. J.Biol.Chem., 283, 2008
|
|
3FRL
| The 2.25 A crystal structure of LipL32, the major surface antigen of Leptospira interrogans serovar Copenhageni | 分子名称: | 2,2',2''-NITRILOTRIETHANOL, CHLORIDE ION, LipL32, ... | 著者 | Farah, C.S, Guzzo, C.R, Hauk, P, Ho, P.L. | 登録日 | 2009-01-08 | 公開日 | 2009-06-16 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure and calcium-binding activity of LipL32, the major surface antigen of pathogenic Leptospira sp. J.Mol.Biol., 390, 2009
|
|
3FZ2
| Crystal structure of the tail terminator protein from phage lambda (gpU-D74A) | 分子名称: | Minor tail protein U, SULFATE ION | 著者 | Pell, L.G, Liu, A, Edmonds, E, Donaldson, L.W, Howell, P.L, Davidson, A.R. | 登録日 | 2009-01-23 | 公開日 | 2009-05-26 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The X-ray crystal structure of the phage lambda tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages. J.Mol.Biol., 389, 2009
|
|
3GIA
| Crystal Structure of ApcT Transporter | 分子名称: | BICINE, DECANE, Uncharacterized protein MJ0609 | 著者 | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2009-03-05 | 公開日 | 2009-08-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structure and mechanism of a na+-independent amino Acid transporter. Science, 325, 2009
|
|
3FZB
| Crystal structure of the tail terminator protein from phage lambda (gpU-WT) | 分子名称: | Minor tail protein U, SULFATE ION | 著者 | Pell, L.G, Liu, A, Edmonds, E, Donaldson, L.W, Howell, P.L, Davidson, A.R. | 登録日 | 2009-01-24 | 公開日 | 2009-05-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The X-ray crystal structure of the phage lambda tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages. J.Mol.Biol., 389, 2009
|
|
3GI9
| Crystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab Fragment | 分子名称: | 7F11 Anti-ApcT Monoclonal Fab Heavy Chain, 7F11 Anti-ApcT Monoclonal Fab Light Chain, Uncharacterized protein MJ0609 | 著者 | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2009-03-05 | 公開日 | 2009-08-18 | 最終更新日 | 2017-06-07 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Structure and mechanism of a na+-independent amino Acid transporter. Science, 325, 2009
|
|
2POA
| Schistosoma mansoni Sm14 Fatty Acid-Binding Protein: improvement of protein stability by substitution of the single Cys62 residue | 分子名称: | 14 kDa fatty acid-binding protein | 著者 | Ramos, C.R.R, Oyama Jr, S, Sforca, M.L, Pertinhez, T.A, Ho, P.L, Spisni, A. | 登録日 | 2007-04-26 | 公開日 | 2008-06-10 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: Structural and functional characterization of a vaccine candidate. Biochim.Biophys.Acta, 1794, 2009
|
|
5FNR
| Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. | 分子名称: | (3S)-3-(4-chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acid, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 | 著者 | Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K. | 登録日 | 2015-11-16 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J.Med.Chem., 59, 2016
|
|
5FNQ
| Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. | 分子名称: | 3-(4-CHLOROPHENYL)PROPANOIC ACID, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 | 著者 | Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K. | 登録日 | 2015-11-16 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J.Med.Chem., 59, 2016
|
|
5FZJ
| Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. | 分子名称: | 2,6-DIMETHYL-4H-PYRANO[3,4-D][1,3]OXAZOL-4-ONE, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 | 著者 | Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K. | 登録日 | 2016-03-14 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J.Med.Chem., 59, 2016
|
|
5FNU
| Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. | 分子名称: | (3S)-3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-(((R)-4-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)phenyl)propanoic acid, CHLORIDE ION, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 | 著者 | Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K. | 登録日 | 2015-11-16 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J.Med.Chem., 59, 2016
|
|