Crystal structure and thermodynamic analysis of diagnostic Fab 106.3 complexed with BNP 5-13 (C10A) reveal basis of selective molecular recognition

Summary for 3E8U

DescriptorFab 106.3 heavy chain, Fab 106.3 light chain, BNP peptide epitope, ... (4 entities in total)
Functional Keywordsfab 106.3, igg1, brain natriuretic peptide (bnp), immune system
Biological sourceMus musculus
Total number of polymer chains3
Total molecular weight48149.18
Longenecker, K.L.,Ruan, Q.,Fry, E.H.,Saldana, S.S.,Brophy, S.E.,Richardson, P.L.,Tetin, S.Y. (deposition date: 2008-08-20, release date: 2009-07-07, Last modification date: 2017-10-25)
Primary citation
Longenecker, K.L.,Ruan, Q.,Fry, E.H.,Saldana, S.C.,Brophy, S.E.,Richardson, P.L.,Tetin, S.Y.
Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A).
Proteins, 76:536-547, 2009
PubMed: 19274732 (PDB entries with the same primary citation)
DOI: 10.1002/prot.22366
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243301.8%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05