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7X3K
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BU of 7x3k by Molmil
Cryo-EM structure of RAC in the State C2 RNC-RAC complex
分子名称: Ribosome-associated complex subunit SSZ1, Zuotin
著者Chen, Y, Gao, N.
登録日2022-03-01
公開日2022-06-29
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (6 Å)
主引用文献Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding.
Nat Commun, 13, 2022
7X34
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BU of 7x34 by Molmil
Cryo-EM structure of RNC-RAC complex in presence of Ssb from S. cerevisiae 2
分子名称: RNA (130-mer), Zuotin
著者Chen, Y, Gao, N.
登録日2022-02-27
公開日2022-06-29
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding.
Nat Commun, 13, 2022
5YE1
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BU of 5ye1 by Molmil
structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 2
分子名称: Mucolipin-1
著者Yang, M, Gao, N.
登録日2017-09-15
公開日2017-12-27
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5Y0Y
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BU of 5y0y by Molmil
RVFV GN-AU
分子名称: GOLD ION, NSmGnGc
著者Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F.
登録日2017-07-19
公開日2017-09-13
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (3.398 Å)
主引用文献Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7UYA
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BU of 7uya by Molmil
Inhibitor bound VIM1
分子名称: (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
著者Fischmann, T.O, Scapin, G.
登録日2022-05-06
公開日2023-05-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.01 Å)
主引用文献Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYD
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BU of 7uyd by Molmil
Inhibitor bound VIM1
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ...
著者Fischmann, T.O, Scapin, G.
登録日2022-05-06
公開日2023-05-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYB
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BU of 7uyb by Molmil
Inhibitor bound VIM1
分子名称: (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
著者Fischmann, T.O, Scapin, G.
登録日2022-05-06
公開日2023-05-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.11 Å)
主引用文献Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYC
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BU of 7uyc by Molmil
Inhibitor bound VIM1
分子名称: (2P)-4'-(piperidin-4-yl)-4-[(piperidin-4-yl)methyl]-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, MAGNESIUM ION, ...
著者Fischmann, T.O, Scapin, G.
登録日2022-05-06
公開日2023-05-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.02 Å)
主引用文献Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
5Y11
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BU of 5y11 by Molmil
SFTSV GN with neutralizing antibody MAb4-5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAb 4-5 heavy chain, MAb 4-5 light chain, ...
著者Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F.
登録日2017-07-19
公開日2017-09-13
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5Y0W
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BU of 5y0w by Molmil
The structure of RVFV Gn head domain
分子名称: NSmGnGc
著者Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F.
登録日2017-07-19
公開日2017-09-13
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5YE5
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BU of 5ye5 by Molmil
structure of endo-lysosomal TRPML1 channel inserting into nanodisc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, mammalian endo-lysosomal TRPML1 channel
著者Yang, M, Gao, N.
登録日2017-09-15
公開日2017-11-15
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YDZ
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BU of 5ydz by Molmil
structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 1
分子名称: mammalian endo-lysosomal TRPML1 channel
著者Yang, M, Gao, N.
登録日2017-09-15
公開日2017-12-27
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
4Z55
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BU of 4z55 by Molmil
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378
分子名称: ALK tyrosine kinase receptor, GLYCEROL, N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
著者Lee, C.C, Spraggon, G.
登録日2015-04-02
公開日2016-02-03
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5YE2
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BU of 5ye2 by Molmil
mammalian endo-lysosomal TRPML1 channel inserting into amphipol
分子名称: mammalian endo-lysosomal TRPML1 channel
著者Yang, M, Gao, N.
登録日2017-09-15
公開日2017-12-27
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5Y10
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BU of 5y10 by Molmil
SFTSV Gn head domain
分子名称: Membrane glycoprotein polyprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F.
登録日2017-07-19
公開日2017-09-13
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6IUF
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BU of 6iuf by Molmil
Crystal structure of Anti-CRISPR protein AcrVA5
分子名称: ACETYL COENZYME *A, GLYCEROL, protein-a
著者Dong, L, Guan, X, Zhu, Y, Huang, Z.
登録日2018-11-28
公開日2019-04-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.052 Å)
主引用文献An anti-CRISPR protein disables type V Cas12a by acetylation.
Nat. Struct. Mol. Biol., 26, 2019
5XLO
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BU of 5xlo by Molmil
Anti-CRISPR proteins AcrF1/2 bound to Csy surveillance complex with a 32nt spacer crRNA backbone region
分子名称: CRISPR-associated protein Csy3, Uncharacterized protein AcrF1, crRNA with 32nt spacer sequence
著者Peng, R, Shi, Y, Gao, G.F.
登録日2017-05-11
公開日2018-01-10
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.
Cell Res., 27, 2017
7CE2
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BU of 7ce2 by Molmil
The Crystal structure of TeNT Hc complexed with neutralizing antibody
分子名称: Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain
著者Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H.
登録日2020-06-21
公開日2021-04-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.
Cell Rep, 35, 2021
5WFY
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BU of 5wfy by Molmil
Crystal structure of DNA-binding domain of the bacteriophage T4 ligase
分子名称: DNA ligase, GLYCEROL
著者Shi, K, Aihara, H.
登録日2017-07-13
公開日2018-09-26
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Nucleic Acids Res., 46, 2018
5XLP
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BU of 5xlp by Molmil
Anti-CRISPR proteins AcrF1/2 bound to Csy surveillance complex with a 20nt spacer crRNA backbone region
分子名称: CRISPR-associated protein Csy3, Uncharacterized protein AcrF1, crRNA with 20nt spacer sequence
著者Peng, R, Shi, Y, Gao, G.F.
登録日2017-05-11
公開日2018-01-10
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.
Cell Res., 27, 2017
5H65
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BU of 5h65 by Molmil
Crystal structure of human POT1 and TPP1
分子名称: Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION
著者Chen, C, Wu, J, Lei, M.
登録日2016-11-10
公開日2017-05-31
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
1S5I
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BU of 1s5i by Molmil
Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure
分子名称: Fab-fragment of monoclonal antibody
著者Pletnev, V.Z, Goryacheva, E.A, Tsygannik, I.N, Nesmeyanov, V.A, Pletnev, S.V, Pangborn, W, Duax, W.
登録日2004-01-21
公開日2004-05-25
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献[A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution].
Bioorg. Khim., 30
7JRA
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BU of 7jra by Molmil
HUMAN TNF-ALPHA IN COMPLEX WITH 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol
分子名称: 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol, GLYCEROL, Tumor necrosis factor
著者Sheriff, S.
登録日2020-08-11
公開日2020-12-09
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF alpha Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J.Med.Chem., 63, 2020
4GX8
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BU of 4gx8 by Molmil
Crystal structure of a DNA polymerase III alpha-epsilon chimera
分子名称: CHLORIDE ION, DNA polymerase III subunit epsilon,DNA polymerase III subunit alpha
著者Robinson, A, Horan, N, Xu, Z.-Q, Dixon, N.E, Oakley, A.J.
登録日2012-09-04
公開日2013-04-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits alpha, {varepsilon}, theta and beta reveals a highly flexible arrangement of the proofreading domain
Nucleic Acids Res., 41, 2013
7CBZ
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BU of 7cbz by Molmil
Crystal structure of T2R-TTL-A31 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl)ethanamide, CALCIUM ION, ...
著者Yang, J.H, Yan, W.
登録日2020-06-15
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.
J.Med.Chem., 64, 2021

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