7UYA

Inhibitor bound VIM1

Summary for 7UYA

• Entry DOI: 10.2210/pdb7uya/pdb
• Descriptor: Beta-lactamase VIM-1, ZINC ION, (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, ... (4 entities in total)
• Functional Keywords: hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 26525.07

Authors

Fischmann, T.O.,Scapin, G. (deposition date: 2022-05-06, release date: 2023-05-24, Last modification date: 2024-03-27)

• Primary citation: Dong, S.,Zhao, Z.,Tang, H.,Li, G.,Pan, J.,Gu, X.,Jiang, J.,Xiao, L.,Scapin, G.,Hunter, D.N.,Yang, D.,Huang, Y.,Bennett, F.,Yang, S.W.,Mandal, M.,Tang, H.,Su, J.,Tudge, C.,deJesus, R.K.,Ding, F.X.,Lombardo, M.,Hicks, J.D.,Fischmann, T.,Mirza, A.,Dayananth, P.,Painter, R.E.,Villafania, A.,Garlisi, C.G.,Zhang, R.,Mayhood, T.W.,Si, Q.,Li, N.,Amin, R.P.,Bhatt, B.,Chen, F.,Regan, C.P.,Regan, H.,Lin, X.,Wu, J.,Leithead, A.,Pollack, S.R.,Scott, J.D.,Nargund, R.P.,Therien, A.G.,Black, T.,Young, K.,Pasternak, A.; Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.; J.Med.Chem., 67:3400-3418, 2024; PubMed: 38387069; DOI: 10.1021/acs.jmedchem.3c01614

Experimental method

X-RAY DIFFRACTION (1.01 Å)