7ENI
 
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7ENM
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7ENR
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7EF1
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7EF2
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7EF3
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7EEZ
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7EF0
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2R6W
 | | Estrogen receptor alpha ligand-binding domain complexed to a SERM | | 分子名称: | Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone | | 著者 | Wang, Y. | | 登録日 | 2007-09-06 | | 公開日 | 2008-04-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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5XG8
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7PEM
 | | Cryo-EM structure of phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state | | 分子名称: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Timcenko, M, Wang, Y, Lyons, J.A, Nissen, P, Lindorff-Larsen, K. | | 登録日 | 2021-08-10 | | 公開日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Substrate Transport and Specificity in a Phospholipid Flippase
To Be Published
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6KZD
 | | Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide | | 分子名称: | 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide, NT-3 growth factor receptor, PHOSPHATE ION | | 著者 | Wang, Y, Zhang, Z.M. | | 登録日 | 2019-09-23 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.708 Å) | | 主引用文献 | Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.
Eur.J.Med.Chem., 179, 2019
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1FB9
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2R6Y
 | | Estrogen receptor alpha ligand-binding domain in complex with a SERM | | 分子名称: | Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl][4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone | | 著者 | Wang, Y. | | 登録日 | 2007-09-06 | | 公開日 | 2008-04-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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6AK4
 | | Crystal structure of human FTO in complex with small-molecule inhibitors | | 分子名称: | (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide, Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION | | 著者 | Wang, Y, Cao, R, Peng, S, Zhang, W, Huang, N. | | 登録日 | 2018-08-30 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
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7BXG
 | | MavC-UBE2N-Ub complex | | 分子名称: | MavC, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N | | 著者 | Gao, P, Wang, Y. | | 登録日 | 2020-04-19 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | | 主引用文献 | Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors.
Nat Commun, 11, 2020
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7BXH
 | | MavC-Lpg2149 complex | | 分子名称: | Lpg2149, MavC | | 著者 | Gao, P, Wang, Y. | | 登録日 | 2020-04-19 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors.
Nat Commun, 11, 2020
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8SPP
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5K13
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5H1K
 | | Crystal structure of WD40 repeat domains of Gemin5 in complex with 13-nt U4 snRNA fragment | | 分子名称: | Gem-associated protein 5, U4 snRNA (5'-R(*GP*CP*AP*AP*UP*UP*UP*UP*UP*GP*AP*CP*A)-3') | | 著者 | Wang, Y, Jin, W, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M. | | 登録日 | 2016-10-10 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
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8HN9
 | | Human SIRT3 Recognizing CCNE2K348la peptide | | 分子名称: | CCNE2 peptide, IMIDAZOLE, NAD-dependent protein deacetylase sirtuin-3, ... | | 著者 | Wang, Y, Ding, W. | | 登録日 | 2022-12-07 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.
Embo Rep., 24, 2023
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6LYH
 | | Crystal structure of tea N9-methyltransferase CkTcS in complex with SAH and 1,3,7-trimethyluric acid | | 分子名称: | 1,3,7-trimethyl-9H-purine-2,6,8-trione, N-methyltransferase CkTcS, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Wang, Y, Zhang, Z.-M. | | 登録日 | 2020-02-14 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.15000319 Å) | | 主引用文献 | Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea.
Nat Commun, 11, 2020
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139D
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3NYL
 | | The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain | | 分子名称: | Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b | | 著者 | Ha, Y, Hu, J, Lee, S, Liu, X, Wang, Y. | | 登録日 | 2010-07-15 | | 公開日 | 2011-07-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Mol.Cell, 15, 2004
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5YVE
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