5UHR

Crystal structure of (Cit)LANFLV heptapeptide segment from islet amyloid polypeptide (IAPP) incorporated into a macrocyclic beta-sheet template

Summary for 5UHR

Entry DOI	10.2210/pdb5uhr/pdb
Descriptor	ORN-CIR-LEU-ALA-ASN-PHE-LEU-VAL-ORN-ILE-LYS-HAO-LYS-A8E, CHLORIDE ION (3 entities in total)
Functional Keywords	amyloid, diabetes, oligomer, tetramer, de novo protein
Biological source	Homo sapiens
Total number of polymer chains	4
Total formula weight	7411.47
Authors	Wang, Y.,Kreutzer, A.G.,Nowick, J.S. (deposition date: 2017-01-11, release date: 2017-07-12, Last modification date: 2023-11-15)
Primary citation	Wang, Y.,Kreutzer, A.G.,Truex, N.L.,Nowick, J.S. A Tetramer Derived from Islet Amyloid Polypeptide. J. Org. Chem., 82:7905-7912, 2017 Cited by PubMed: 28661686 DOI: 10.1021/acs.joc.7b01116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.798 Å)

Structure validation