8I7Q

Cobalt and Calcium coordinated Concanavalin A at pH 7.4 from Canavalia ensiformis

Summary for 8I7Q

Entry DOI	10.2210/pdb8i7q/pdb
Descriptor	Concanavalin A, COBALT (II) ION, CALCIUM ION, ... (4 entities in total)
Functional Keywords	lectin, sugar binding protein
Biological source	Canavalia ensiformis
Total number of polymer chains	1
Total formula weight	25691.44
Authors	Hwang, Y.,Jeong, J.H.,Lee, S.J. (deposition date: 2023-02-01, release date: 2023-12-27, Last modification date: 2024-01-17)
Primary citation	Hwang, Y.,Jeong, J.H.,Lee, D.H.,Lee, S.J. Selective interactions of Co 2+ -Ca 2+ -concanavalin A with high mannose N -glycans. Dalton Trans, 53:428-433, 2024 Cited by PubMed Abstract: Concanavalin A (ConA) has an intrinsic binding affinity to carbohydrates. Here, we obtained Co-Ca-ConA (2.83 Å, PDB: 8I7Q) X-ray crystallography by substituting native ConA (Mn-Ca); it has binding selectivity for high-mannose -glycan similar to native ConA. Our findings may thus inform antiviral reagent design. PubMed: 38086668 DOI: 10.1039/d3dt03575a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.83 Å)

Structure validation