5UJT

Crystal structure of human HLA-DQ8 in complex with insulin mimotope binding in register 3

Summary for 5UJT

• Entry DOI: 10.2210/pdb5ujt/pdb
• Descriptor: MHC class II antigen, MHC class II HLA-DQ-beta-1, insulin mimotope, ... (6 entities in total)
• Functional Keywords: insulin, type i diabetes, t cell, autoimmune disease, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 136189.88

Authors

Wang, Y.,Dai, S. (deposition date: 2017-01-18, release date: 2017-12-20, Last modification date: 2023-10-04)

• Primary citation: Wang, Y.,Sosinowski, T.,Novikov, A.,Crawford, F.,Neau, D.B.,Yang, J.,Kwok, W.W.,Marrack, P.,Kappler, J.W.,Dai, S.; C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.; Proc. Natl. Acad. Sci. U.S.A., 115:162-167, 2018; PubMed: 29255035; DOI: 10.1073/pnas.1716527115

Experimental method

X-RAY DIFFRACTION (1.94 Å)