4ULW
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3DAD
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![BU of 3dad by Molmil](/molmil-images/mine/3dad) | Crystal structure of the N-terminal regulatory domains of the formin FHOD1 | Descriptor: | FH1/FH2 domain-containing protein 1 | Authors: | Schulte, A, Stolp, B, Schonichen, A, Pylypenko, O, Rak, A, Fackler, O.T, Geyer, M. | Deposit date: | 2008-05-29 | Release date: | 2008-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Human Formin FHOD1 Contains a Bipartite Structure of FH3 and GTPase-Binding Domains Required for Activation. Structure, 16, 2008
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5N7I
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1H4Q
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![BU of 1h4q by Molmil](/molmil-images/mine/1h4q) | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG), ATP and prolinol | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PROLYL-TRNA SYNTHETASE, PYRROLIDINE-2-CARBALDEHYDE, ... | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | Deposit date: | 2001-05-13 | Release date: | 2001-06-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
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1H4S
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![BU of 1h4s by Molmil](/molmil-images/mine/1h4s) | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG) and a prolyl-adenylate analogue | Descriptor: | '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, PROLYL-TRNA SYNTHETASE, SULFATE ION, ... | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | Deposit date: | 2001-05-14 | Release date: | 2001-06-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
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1H4T
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1HC7
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![BU of 1hc7 by Molmil](/molmil-images/mine/1hc7) | Prolyl-tRNA synthetase from Thermus thermophilus | Descriptor: | PROLYL-TRNA SYNTHETASE, ZINC ION | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | Deposit date: | 2001-04-26 | Release date: | 2001-06-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
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1OVM
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![BU of 1ovm by Molmil](/molmil-images/mine/1ovm) | Crystal structure of Indolepyruvate decarboxylase from Enterobacter cloacae | Descriptor: | Indole-3-pyruvate decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | Authors: | Schutz, A, Sandalova, T, Ricagno, S, Hubner, G, Konig, S, Schneider, G. | Deposit date: | 2003-03-27 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid Eur.J.Biochem., 270, 2003
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2WBU
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![BU of 2wbu by Molmil](/molmil-images/mine/2wbu) | CRYSTAL STRUCTURE OF THE ZINC FINGER DOMAIN OF KLF4 BOUND TO ITS TARGET DNA | Descriptor: | 5'-D(*DGP*DAP*DGP*DGP*DCP*DGP*DTP* DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DAP*DCP*DGP*DCP* DCP*DTP*DC)-3', KRUEPPEL-LIKE FACTOR 4, ... | Authors: | Schuetz, A, Zocher, G, Carstanjen, D, Heinemann, U. | Deposit date: | 2009-03-05 | Release date: | 2010-04-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Structure of the Klf4 DNA-Binding Domain Links to Self-Renewal and Macrophage Differentiation. Cell.Mol.Life Sci., 68, 2011
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5N7H
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5N7K
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6SKA
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![BU of 6ska by Molmil](/molmil-images/mine/6ska) | Teneurin 2 in complex with Latrophilin 1 Lec-Olf domains | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor L1, ... | Authors: | Chu, A, Carrasquero, M.A, Lowe, E, Seiradake, E. | Deposit date: | 2019-08-15 | Release date: | 2020-02-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.86 Å) | Cite: | Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Cell, 180, 2020
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8CJL
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![BU of 8cjl by Molmil](/molmil-images/mine/8cjl) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor TPT-004 | Descriptor: | 3-ethyl-8-[(2-methyl-5~{H}-imidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-(oxetan-3-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJO
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![BU of 8cjo by Molmil](/molmil-images/mine/8cjo) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-004 | Descriptor: | 1-[(3~{S})-3-(4-chloranyl-2-fluoranyl-phenyl)-1,4,8-triazatricyclo[7.4.0.0^{2,7}]trideca-2(7),8-dien-4-yl]-2-(2-ethyl-6-methyl-pyridin-3-yl)oxy-ethanone, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.86633706 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJM
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![BU of 8cjm by Molmil](/molmil-images/mine/8cjm) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047 | Descriptor: | 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJK
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![BU of 8cjk by Molmil](/molmil-images/mine/8cjk) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-098 | Descriptor: | 3-ethyl-8-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45914972 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJI
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![BU of 8cji by Molmil](/molmil-images/mine/8cji) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-052 | Descriptor: | FE (III) ION, Tryptophan 5-hydroxylase 1, methyl (2~{S})-2-azanyl-3-[[3-[[3-ethyl-2,6-bis(oxidanylidene)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purin-7-yl]methyl]phenyl]carbonylamino]propanoate | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJJ
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![BU of 8cjj by Molmil](/molmil-images/mine/8cjj) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-057 | Descriptor: | 3-ethyl-7-(phenylmethyl)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.66415656 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8CJN
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![BU of 8cjn by Molmil](/molmil-images/mine/8cjn) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-070 | Descriptor: | 3-ethyl-7-[(4-phenylphenyl)methyl]-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.68080938 Å) | Cite: | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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3C0Y
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![BU of 3c0y by Molmil](/molmil-images/mine/3c0y) | Crystal structure of catalytic domain of human histone deacetylase HDAC7 | Descriptor: | Histone deacetylase 7a, POTASSIUM ION, ZINC ION | Authors: | Min, J.R, Schuetz, A, Allali-Hassani, A, Loppnau, P, Kwiatkowski, N.P, Mazitschek, R, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-21 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
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1Z4R
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![BU of 1z4r by Molmil](/molmil-images/mine/1z4r) | Human GCN5 Acetyltransferase | Descriptor: | ACETYL COENZYME *A, General control of amino acid synthesis protein 5-like 2 | Authors: | Dong, A, Bernstein, G, Schuetz, A, Antoshenko, T, Wu, H, Loppnau, P, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Plotnikov, A, Structural Genomics Consortium (SGC) | Deposit date: | 2005-03-16 | Release date: | 2005-03-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A Proteins, 68, 2007
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3C0Z
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![BU of 3c0z by Molmil](/molmil-images/mine/3c0z) | Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with SAHA | Descriptor: | Histone deacetylase 7a, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... | Authors: | Min, J, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-21 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
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3C10
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![BU of 3c10 by Molmil](/molmil-images/mine/3c10) | Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with Trichostatin A (TSA) | Descriptor: | Histone deacetylase 7a, POTASSIUM ION, TRICHOSTATIN A, ... | Authors: | Min, J, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-21 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
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7ZIH
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![BU of 7zih by Molmil](/molmil-images/mine/7zih) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor AG-01-128 | Descriptor: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... | Authors: | Schuetz, A, Gogolin, A, Pfeifer, J, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | Deposit date: | 2022-04-08 | Release date: | 2022-09-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.46890831 Å) | Cite: | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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7ZIK
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![BU of 7zik by Molmil](/molmil-images/mine/7zik) | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401 | Descriptor: | (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Schuetz, A, Heinemann, U. | Deposit date: | 2022-04-08 | Release date: | 2022-09-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.58925915 Å) | Cite: | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
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