3C10

Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with Trichostatin A (TSA)

Replaces:  2PQP

Summary for 3C10

• Entry DOI: 10.2210/pdb3c10/pdb
• Related: 2NVR 3C0Y 3C0Z
• Descriptor: Histone deacetylase 7a, ZINC ION, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: hdac, structural genomics, structural genomics consortium, sgc, alternative splicing, chromatin regulator, cytoplasm, hydrolase, nucleus, phosphoprotein, polymorphism, repressor, transcription, transcription regulation
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q8WUI4
• Total number of polymer chains: 3
• Total formula weight: 138089.17

Authors

Min, J.,Schuetz, A.,Loppnau, P.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Plotnikov, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-21, release date: 2008-02-19, Last modification date: 2023-08-30)

• Primary citation: Schuetz, A.,Min, J.,Allali-Hassani, A.,Schapira, M.,Shuen, M.,Loppnau, P.,Mazitschek, R.,Kwiatkowski, N.P.,Lewis, T.A.,Maglathin, R.L.,McLean, T.H.,Bochkarev, A.,Plotnikov, A.N.,Vedadi, M.,Arrowsmith, C.H.; Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.; J.Biol.Chem., 283:11355-11363, 2008; PubMed: 18285338; DOI: 10.1074/jbc.M707362200

Experimental method

X-RAY DIFFRACTION (2 Å)