3C0Y
Crystal structure of catalytic domain of human histone deacetylase HDAC7
Replaces: 2NVRReplaces: 2I4YSummary for 3C0Y
Entry DOI | 10.2210/pdb3c0y/pdb |
Related | 2NVR 3C0Z 3C10 |
Descriptor | Histone deacetylase 7a, ZINC ION, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | histone deacetylase, structural genomics, structural genomics consortium, sgc, alternative splicing, chromatin regulator, cytoplasm, hydrolase, nucleus, phosphoprotein, polymorphism, repressor, transcription, transcription regulation |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q8WUI4 |
Total number of polymer chains | 3 |
Total formula weight | 137182.06 |
Authors | Min, J.R.,Schuetz, A.,Allali-Hassani, A.,Loppnau, P.,Kwiatkowski, N.P.,Mazitschek, R.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Bochkarev, A.,Plotnikov, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-21, release date: 2008-02-19, Last modification date: 2023-08-30) |
Primary citation | Schuetz, A.,Min, J.,Allali-Hassani, A.,Schapira, M.,Shuen, M.,Loppnau, P.,Mazitschek, R.,Kwiatkowski, N.P.,Lewis, T.A.,Maglathin, R.L.,McLean, T.H.,Bochkarev, A.,Plotnikov, A.N.,Vedadi, M.,Arrowsmith, C.H. Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283:11355-11363, 2008 Cited by PubMed: 18285338DOI: 10.1074/jbc.M707362200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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