1L1S
 
 | | Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum | | Descriptor: | hypothetical protein MTH1491 | | Authors: | Christendat, D, Saridakis, V, Kim, Y, Kumar, P.A, Xu, X, Semesi, A, Joachimiak, A, Arrowsmith, C.H, Edwards, A.M, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2002-02-19 | | Release date: | 2002-05-29 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.
Protein Sci., 11, 2002
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1KJN
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1EIJ
 | | NMR ENSEMBLE OF METHANOBACTERIUM THERMOAUTOTROPHICUM PROTEIN 1615 | | Descriptor: | HYPOTHETICAL PROTEIN MTH1615 | | Authors: | Christendat, D, Booth, V, Gernstein, M, Arrowsmith, C.H, Edwards, A.M, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2000-02-25 | | Release date: | 2000-11-03 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural proteomics of an archaeon.
Nat.Struct.Biol., 7, 2000
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1EJE
 | | CRYSTAL STRUCTURE OF AN FMN-BINDING PROTEIN | | Descriptor: | FLAVIN MONONUCLEOTIDE, FMN-BINDING PROTEIN, NICKEL (II) ION, ... | | Authors: | Christendat, D, Saridakis, V, Bochkarev, A, Arrowsmith, C, Edwards, A.M, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2000-03-02 | | Release date: | 2000-10-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural proteomics of an archaeon.
Nat.Struct.Biol., 7, 2000
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1EP0
 | | HIGH RESOLUTION CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM | | Descriptor: | DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE | | Authors: | Christendat, D, Saridakis, V, Bochkarev, A, Pai, E.F, Arrowsmith, C.H, Edwards, A.M, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2000-03-24 | | Release date: | 2000-12-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
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1EPZ
 | | CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOASE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM WITH BOUND LIGAND. | | Descriptor: | DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE, THYMIDINE-5'-DIPHOSPHATE | | Authors: | Christendat, D, Saridakis, V, Bochkarev, A, Pai, E.F, Arrowsmith, C, Edwards, A.M. | | Deposit date: | 2000-03-30 | | Release date: | 2000-12-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
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4PGJ
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6BMB
 | | Crystal structure of Arabidopsis Dehydroquinate dehydratase-shikimate dehydrogenase (T381G mutant) in complex with tartrate and shikimate | | Descriptor: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, ... | | Authors: | Christendat, D, Peek, J. | | Deposit date: | 2017-11-14 | | Release date: | 2017-12-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.077 Å) | | Cite: | Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases.
Plant J., 2018
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6BMQ
 | | Crystal structure of Arabidopsis Dehydroquinate dehydratase-shikimate dehydrogenase (T381G mutant) in complex with tartrate and shikimate | | Descriptor: | (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, ... | | Authors: | Christendat, D, Peek, J. | | Deposit date: | 2017-11-15 | | Release date: | 2018-09-26 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.077 Å) | | Cite: | Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases.
Plant J., 2018
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2O7Q
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2O7S
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3PWZ
 | | Crystal structure of an Ael1 enzyme from Pseudomonas putida | | Descriptor: | Shikimate dehydrogenase 3 | | Authors: | Christendat, D, Peek, J. | | Deposit date: | 2010-12-09 | | Release date: | 2011-09-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.705 Å) | | Cite: | Structural and mechanistic analysis of a novel class of shikimate dehydrogenases: evidence for a conserved catalytic mechanism in the shikimate dehydrogenase family.
Biochemistry, 50, 2011
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4UZM
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4U3X
 | | Structure of a human VH antibody domain binding to the cleft of hen egg lysozyme | | Descriptor: | 1,2-ETHANEDIOL, Human VH domain antibody, Lysozyme C | | Authors: | Rouet, R, Langley, D.B, Christ, D. | | Deposit date: | 2014-07-23 | | Release date: | 2015-03-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies
J.Biol.Chem., 290, 2015
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5VJQ
 | | Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I) | | Descriptor: | CHLORIDE ION, GLYCEROL, HyHEL10 heavy chain Fab fragment carrying three mutations; I29F, ... | | Authors: | Langley, D.B, Christ, D. | | Deposit date: | 2017-04-19 | | Release date: | 2018-04-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
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6MH2
 | | Structure of Herceptin Fab without antigen | | Descriptor: | Herceptin Fab arm heavy chain, Herceptin Fab arm light chain | | Authors: | Luthra, A, Langley, D.B, Christie, M, Christ, D. | | Deposit date: | 2018-09-17 | | Release date: | 2019-05-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Human Antibody Bispecifics through Phage Display Selection.
Biochemistry, 58, 2019
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6DSI
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6DN0
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6BFT
 | | Structure of Bevacizumab Fab mutant in complex with VEGF | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ... | | Authors: | Christie, M, Christ, D. | | Deposit date: | 2017-10-27 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Stable human IgG antibody therapeutics with native
framework structure
To Be Published
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6BGT
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4X4Z
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4X4X
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3UPC
 | | A general strategy for the generation of human antibody variable domains with increased aggregation resistance | | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | | Authors: | Dudgeon, K, Rouet, R, Kokmeijer, I, Langley, D.B, Christ, D. | | Deposit date: | 2011-11-17 | | Release date: | 2012-06-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
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3UPA
 | | A general strategy for the generation of human antibody variable domains with increased aggregation resistance | | Descriptor: | kappa light chain variable domain | | Authors: | Dudgeon, K, Rouet, R, Kokmeijer, I, Langley, D.B, Christ, D. | | Deposit date: | 2011-11-17 | | Release date: | 2012-06-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
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4N1C
 | | Structural evidence for antigen receptor evolution | | Descriptor: | Lysozyme C, immunoglobulin variable light chain domain | | Authors: | Langley, D.B, Rouet, R, Roome, B, Stock, D, Christ, D. | | Deposit date: | 2013-10-03 | | Release date: | 2014-10-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural reconstruction of protein ancestry.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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