3STB
| A complex of two editosome proteins and two nanobodies | Descriptor: | MP18 RNA editing complex protein, RNA-editing complex protein MP42, single domain antibody VHH | Authors: | Park, Y.-J, Hol, W. | Deposit date: | 2011-07-09 | Release date: | 2011-11-02 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. Nucleic Acids Res., 40, 2012
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6F2G
| Bacterial asc transporter crystal structure in open to in conformation | Descriptor: | Nanobody 74, Putative amino acid/polyamine transport protein, ZINC ION | Authors: | Fort, J, Errasti-Murugarren, E, Carpena, X, Palacin, M, Fita, I. | Deposit date: | 2017-11-24 | Release date: | 2019-04-24 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction. Nat Commun, 10, 2019
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6F2W
| Bacterial asc transporter crystal structure in open to in conformation | Descriptor: | ALPHA-AMINOISOBUTYRIC ACID, Nanobody 74, Putative amino acid/polyamine transport protein, ... | Authors: | Fort, J, Errasti-Murugarren, E, Carpena, X, Palacin, M, Fita, I. | Deposit date: | 2017-11-27 | Release date: | 2019-04-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction. Nat Commun, 10, 2019
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8E0G
| Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aS,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indole-1,10-diol, CHOLESTEROL, ... | Authors: | Munro, T.A. | Deposit date: | 2022-08-09 | Release date: | 2023-10-18 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
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4I70
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4I74
| Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 and allosterically inhibited by a Ni2+ ion | Descriptor: | (2R,3R,4S)-2-(hydroxymethyl)-1-[(4-hydroxythieno[3,2-d]pyrimidin-7-yl)methyl]pyrrolidine-3,4-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | Authors: | Giannese, F, Degano, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-07 | Last modified: | 2013-12-18 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69, 2013
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5GXB
| crystal structure of a LacY/Nanobody complex | Descriptor: | Lactose permease, nanobody | Authors: | Jiang, X, Wu, J.P, Yan, N, Kaback, H.R. | Deposit date: | 2016-09-16 | Release date: | 2016-10-26 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Proc.Natl.Acad.Sci.USA, 113, 2016
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4I75
| Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with the NiTris metalorganic complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Inosine-adenosine-guanosine-nucleoside hydrolase, ... | Authors: | Giannese, F, Degano, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69, 2013
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4I73
| Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 | Descriptor: | (2R,3R,4S)-2-(hydroxymethyl)-1-[(4-hydroxythieno[3,2-d]pyrimidin-7-yl)methyl]pyrrolidine-3,4-diol, CALCIUM ION, Inosine-adenosine-guanosine-nucleoside hydrolase, ... | Authors: | Giannese, F, Degano, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-07 | Last modified: | 2013-12-18 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69, 2013
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4I71
| Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound | Descriptor: | (2R,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | Authors: | Giannese, F, Degano, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69, 2013
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4I72
| Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, CALCIUM ION, ... | Authors: | Giannese, F, Degano, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-07 | Last modified: | 2013-12-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69, 2013
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5IKC
| X-RAY STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN in complex with FAB | Descriptor: | CHLORIDE ION, Ighg protein, MAb 6H10 light chain, ... | Authors: | Ruf, A, Stihle, M, Benz, J, Thoma, R, Rudolph, M.G. | Deposit date: | 2016-03-03 | Release date: | 2016-05-18 | Last modified: | 2020-03-11 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies. J.Biol.Chem., 291, 2016
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7RTH
| Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | Authors: | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | Deposit date: | 2021-08-13 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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2GSP
| RIBONUCLEASE T1/2',3'-CGPS AND 3'-GMP, 2 DAYS | Descriptor: | CALCIUM ION, GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, GUANOSINE-3'-MONOPHOSPHATE, ... | Authors: | Zegers, I, Wyns, L. | Deposit date: | 1997-12-02 | Release date: | 1998-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography. Nat.Struct.Biol., 5, 1998
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6ZG3
| the structure of ECF PanT transporter in a complex with a nanobody | Descriptor: | CA14381 nanobody, CITRIC ACID, Conserved hypothetical membrane protein, ... | Authors: | Setyawati, I, Guskov, A, Slotboom, D.J. | Deposit date: | 2020-06-18 | Release date: | 2021-03-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters. Elife, 9, 2020
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6B20
| Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator | Descriptor: | CHLORIDE ION, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... | Authors: | Gulati, S, Kiser, P.D, Palczewski, K. | Deposit date: | 2017-09-19 | Release date: | 2018-05-30 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun, 9, 2018
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7QL5
| Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | Deposit date: | 2021-12-19 | Release date: | 2022-02-09 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
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7QKO
| Torpedo muscle-type nicotinic acetylcholine receptor - Resting conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, ... | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | Deposit date: | 2021-12-18 | Release date: | 2022-02-09 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
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7QL6
| Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | Descriptor: | 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | Deposit date: | 2021-12-19 | Release date: | 2022-02-09 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
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5M7M
| Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity | Descriptor: | CHLORIDE ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, IODIDE ION, ... | Authors: | Wolhkoning, A, Fleury, D, Leonard, P, Triballeau, N, Mollat, P, Vercheval, L. | Deposit date: | 2016-10-28 | Release date: | 2017-08-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. J. Med. Chem., 60, 2017
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3K81
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3K80
| Structure of essential protein from Trypanosoma brucei | Descriptor: | Antibody, MP18 RNA editing complex protein | Authors: | Wu, M. | Deposit date: | 2009-10-13 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J.Struct.Biol., 174, 2011
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3K7U
| Structure of essential protein from Trypanosoma brucei | Descriptor: | Antibody, MP18 RNA editing complex protein | Authors: | Wu, M. | Deposit date: | 2009-10-13 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J.Struct.Biol., 174, 2011
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8FD1
| Crystal structure of photoactivated rhodopsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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8FD0
| Crystal structure of bovine rod opsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.71 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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