8WXT
 
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8XFB
 | | Cryo-EM structure of partial dimeric WDR11-FAM91A1 complex | | Descriptor: | Protein FAM91A1, WD repeat-containing protein 11 | | Authors: | Jia, G.W, Deng, Q.H, Su, Z.M, Jia, D. | | Deposit date: | 2023-12-13 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Cell, 187, 2024
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8WXQ
 | | Structure of WDR5 in complex with WIN motif containing MBD3C | | Descriptor: | GLY-ALA-ALA-ARG-CYS-ARG-VAL-PHE-SER-PRO, WD repeat-containing protein 5 | | Authors: | Xu, L, Yang, Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode.
J.Biol.Chem., 300, 2024
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8XXQ
 | | Structural of methylmalonate semialdehyde dehydrogenase ALDH6A1 | | Descriptor: | Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial | | Authors: | Su, G, Xu, Y, Luan, X. | | Deposit date: | 2024-01-18 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
Medicine Plus, 1, 2024
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8WXU
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8WXR
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8WXV
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8WXX
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3CL9
 | | Structure of bifunctional TcDHFR-TS in complex with MTX | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), ... | | Authors: | Schormann, N, Senkovich, O, Chattopadhyay, D. | | Deposit date: | 2008-03-18 | | Release date: | 2009-01-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
Proteins, 73, 2008
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3DG6
 | | Crystal structure of muconate lactonizing enzyme from Mucobacterium Smegmatis complexed with muconolactone | | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase, [(2S)-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | | Authors: | Fedorov, A.A, Fedorov, E.V, Sakai, A, Gerlt, J.A, Almo, S.C. | | Deposit date: | 2008-06-12 | | Release date: | 2009-03-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes
Biochemistry, 48, 2009
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3DG7
 | | Crystal structure of muconate lactonizing enzyme from Mucobacterium Smegmatis complexed with muconolactone | | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase, [(2S)-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | | Authors: | Fedorov, A.A, Fedorov, E.V, Sakai, A, Gerlt, J.A, Almo, S.C. | | Deposit date: | 2008-06-12 | | Release date: | 2009-03-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes
Biochemistry, 48, 2009
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3DG3
 | | Crystal structure of muconate lactonizing enzyme from Mucobacterium Smegmatis | | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase | | Authors: | Fedorov, A.A, Fedorov, E.V, Sakai, A, Gerlt, J.A, Almo, S.C. | | Deposit date: | 2008-06-12 | | Release date: | 2009-03-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes
Biochemistry, 48, 2009
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3DGB
 | | Crystal structure of muconate lactonizing enzyme from Pseudomonas Fluorescens complexed with muconolactone | | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase, [(2S)-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | | Authors: | Fedorov, A.A, Fedorov, E.V, Sauder, J.M, Burley, S.K, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2008-06-13 | | Release date: | 2009-03-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes
Biochemistry, 48, 2009
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8Z9C
 | | Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state I | | Descriptor: | Protein structure, RNA (41-MER), RNA (48-MER), ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-04-23 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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8Z4L
 | | Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I | | Descriptor: | RNA (40-MER), RNA (49-MER), ZINC ION, ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-04-17 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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8Z4J
 | | Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II | | Descriptor: | Protein structure, RNA (34-MER), RNA (38-MER), ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-04-17 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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8Z9E
 | | Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state II | | Descriptor: | Protein structure, RNA (34-MER), RNA (39-MER), ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-04-23 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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8YHE
 | | Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II | | Descriptor: | RNA (29-MER), RNA (46-MER), ZINC ION, ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-02-28 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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8Z99
 | | Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state +I | | Descriptor: | RNA (49-MER), RNA (54-MER), ZINC ION, ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-04-22 | | Release date: | 2024-08-21 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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8YHD
 | | Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state I | | Descriptor: | RNA (35-MER), RNA (53-MER), ZINC ION, ... | | Authors: | Zhang, H, Deng, Z, Li, X. | | Deposit date: | 2024-02-28 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
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1IJC
 | | Solution Structure of Bucandin, a Neurotoxin from the Venom of the Malayan Krait | | Descriptor: | bucandin | | Authors: | Torres, A.M, Kini, R.M, Nirthanan, S, Kuchel, P.W. | | Deposit date: | 2001-04-25 | | Release date: | 2001-12-21 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | NMR structure of bucandin, a neurotoxin from the venom of the Malayan krait (Bungarus candidus).
Biochem.J., 360, 2001
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4X1K
 | | Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications | | Descriptor: | 2-methyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Parris, K.D. | | Deposit date: | 2014-11-24 | | Release date: | 2015-03-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J.Med.Chem., 57, 2014
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6WKN
 | | PL-bound rat TRPV2 in nanodiscs | | Descriptor: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | | Authors: | Pumroy, R.P, Moiseenkova-Bell, V.Y. | | Deposit date: | 2020-04-16 | | Release date: | 2021-04-21 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Acs Cent.Sci., 7, 2021
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6IIU
 | | Crystal structure of the human thromboxane A2 receptor bound to ramatroban | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, CHOLESTEROL, ... | | Authors: | Fan, H, Zhao, Q, Wu, B. | | Deposit date: | 2018-10-07 | | Release date: | 2018-12-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
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6ITA
 | | Crystal structure of intracellular B30.2 domain of BTN3A1 mutant | | Descriptor: | Butyrophilin subfamily 3 member A1 | | Authors: | Yang, Y.Y, Liu, W.D, Cai, N.N, Chen, C.C, Guo, R.T, Zhang, Y.H. | | Deposit date: | 2018-11-20 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
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