8HT3
 
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1QZ2
 | | Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90 | | Descriptor: | 5-mer peptide from Heat shock protein HSP 90, FK506-binding protein 4 | | Authors: | Wu, B, Li, P, Lou, Z, Liu, Y, Ding, Y, Shu, C, Shen, B, Rao, Z. | | Deposit date: | 2003-09-15 | | Release date: | 2004-06-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1Q1C
 | | Crystal structure of N(1-260) of human FKBP52 | | Descriptor: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, FK506-binding protein 4 | | Authors: | Wu, B, Li, P, Lou, Z, Ding, Y, Shu, C, Shen, B, Rao, Z. | | Deposit date: | 2003-07-18 | | Release date: | 2004-06-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Proc.Natl.Acad.Sci.USA, 101, 2004
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8VT4
 | | Cryo-EM structure of human ABC transporter ABCC1 | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Multidrug resistance-associated protein 1 | | Authors: | Shinde, O, Li, P. | | Deposit date: | 2024-01-25 | | Release date: | 2024-12-25 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export.
Immunity, 58, 2025
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6ASK
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6ASL
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1SVS
 | | Structure of the K180P mutant of Gi alpha subunit bound to GppNHp. | | Descriptor: | Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ... | | Authors: | Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. | | Deposit date: | 2004-03-29 | | Release date: | 2004-06-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1SVK
 | | Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | | Authors: | Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. | | Deposit date: | 2004-03-29 | | Release date: | 2004-06-01 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
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3NMQ
 | | Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor | | Descriptor: | 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol, Heat shock protein HSP 90-beta | | Authors: | Arndt, J.W, Yun, T.J, Harning, E.K, Giza, K, Rabah, D, Li, P, Luchetti, D, Shi, J, Manning, A, Kehry, M.R. | | Deposit date: | 2010-06-22 | | Release date: | 2010-12-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
J.Immunol., 186, 2011
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4MZ7
 | | Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Zhu, C, Gao, W, Zhao, K, Qin, X, Zhang, Y, Peng, X, Zhang, L, Dong, Y, Zhang, W, Li, P, Wei, W, Gong, Y, Yu, X.F. | | Deposit date: | 2013-09-29 | | Release date: | 2013-11-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
Nat Commun, 4, 2013
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5UL6
 | | The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions | | Descriptor: | Adapter molecule crk, Proline-rich motif of nonstructural protein 1 of influenza a virus | | Authors: | Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H. | | Deposit date: | 2017-01-24 | | Release date: | 2017-08-09 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The Molecular Mechanisms Underlying the Hijack of Host Proteins by the 1918 Spanish Influenza Virus.
ACS Chem. Biol., 12, 2017
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2AYO
 | | Structure of USP14 bound to ubquitin aldehyde | | Descriptor: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 14 | | Authors: | Hu, M, Li, P, Jeffrey, P.D, Shi, Y. | | Deposit date: | 2005-09-07 | | Release date: | 2005-10-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
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5W4Y
 | | Crystal Structure of Riboflavin Lyase (RcaE) with cofactor FMN | | Descriptor: | FLAVIN MONONUCLEOTIDE, Riboflavin Lyase | | Authors: | Bhandari, D.M, Chakrabarty, Y, Zhao, B, Wood, J, Li, P, Begley, T.P. | | Deposit date: | 2017-06-13 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Cannibalism Among the Flavins: a Novel C-N Bond Cleavage in Riboflavin Catabolism Mediated by Flavin-Generated Superoxide Radical
To be Published
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5W4Z
 | | Crystal Structure of Riboflavin Lyase (RcaE) with modified FMN and substrate Riboflavin | | Descriptor: | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-3-O-phosphono-D-ribitol, RIBOFLAVIN, Riboflavin Lyase | | Authors: | Bhandari, D.M, Chakrabarty, Y, Zhao, B, Wood, J, Li, P, Begley, T.P. | | Deposit date: | 2017-06-13 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Cannibalism Among the Flavins: a Novel C-N Bond Cleavage in Riboflavin Catabolism Mediated by Flavin-Generated Superoxide Radical
To be Published
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5JEK
 | | Phosphorylated MAVS in complex with IRF-3 | | Descriptor: | Interferon regulatory factor 3, MAVS peptide | | Authors: | Zhao, B, Li, P. | | Deposit date: | 2016-04-18 | | Release date: | 2016-06-15 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5W48
 | | Crystal Structure of Riboflavin Lyase (RcaE) | | Descriptor: | Riboflavin Lyase, SULFATE ION | | Authors: | Bhandari, D.M, Chakrabarty, Y, Zhao, B, Wood, J, Li, P, Begley, T.P. | | Deposit date: | 2017-06-09 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Cannibalism Among the Flavins: a Novel C-N Bond Cleavage in Riboflavin Catabolism Mediated by Flavin-Generated Superoxide Radical
To be Published
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5JEM
 | | Complex of IRF-3 with CBP | | Descriptor: | CREB-binding protein, Interferon regulatory factor 3 | | Authors: | Zhao, B, Li, P. | | Deposit date: | 2016-04-18 | | Release date: | 2016-06-15 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5VJ0
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5JER
 | | Structure of Rotavirus NSP1 bound to IRF-3 | | Descriptor: | Interferon regulatory factor 3, Rotavirus NSP1 peptide | | Authors: | Zhao, B, Li, P. | | Deposit date: | 2016-04-18 | | Release date: | 2016-06-15 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.913 Å) | | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2AYN
 | | Structure of USP14, a proteasome-associated deubiquitinating enzyme | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 14 | | Authors: | Hu, M, Li, P, Jeffrey, P.D, Shi, Y. | | Deposit date: | 2005-09-07 | | Release date: | 2005-10-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
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8K52
 | | Cryo-EM structure of chitin synthase | | Descriptor: | MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, chitin synthase | | Authors: | Zhang, X, Niu, S, Li, P, Bi, Y. | | Deposit date: | 2023-07-20 | | Release date: | 2024-12-04 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Chitin Translocation Is Functionally Coupled with Synthesis in Chitin Synthase.
Int J Mol Sci, 25, 2024
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2JRE
 | | C60-1, a PDZ domain designed using statistical coupling analysis | | Descriptor: | C60-1 PDZ domain peptide | | Authors: | Larson, C, Stiffler, M, Li, P, Rosen, M, MacBeath, G, Ranganathan, R. | | Deposit date: | 2007-06-25 | | Release date: | 2008-07-01 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | C60-1, a PDZ domain designed using statistical coupling analysis
To be Published
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7F09
 | | Crystal structure of the HLH-Lz domain of human TFE3 | | Descriptor: | 1,2-ETHANEDIOL, Transcription factor E3, ZINC ION | | Authors: | Yang, G, Li, P, Liu, Z, Wu, S, Zhuang, C, Qiao, H, Fang, P, Wang, J. | | Deposit date: | 2021-06-03 | | Release date: | 2021-07-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the dimerization mechanism of human transcription factor E3.
Biochem.Biophys.Res.Commun., 569, 2021
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8FJQ
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8FJR
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