3NMQ
Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor
Summary for 3NMQ
Entry DOI | 10.2210/pdb3nmq/pdb |
Descriptor | Heat shock protein HSP 90-beta, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol (3 entities in total) |
Functional Keywords | atpase, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08238 |
Total number of polymer chains | 1 |
Total formula weight | 27100.02 |
Authors | Arndt, J.W.,Yun, T.J.,Harning, E.K.,Giza, K.,Rabah, D.,Li, P.,Luchetti, D.,Shi, J.,Manning, A.,Kehry, M.R. (deposition date: 2010-06-22, release date: 2010-12-22, Last modification date: 2024-03-13) |
Primary citation | Yun, T.J.,Harning, E.K.,Giza, K.,Rabah, D.,Li, P.,Arndt, J.W.,Luchetti, D.,Biamonte, M.A.,Shi, J.,Lundgren, K.,Manning, A.,Kehry, M.R. EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity. J.Immunol., 186:563-575, 2011 Cited by PubMed: 21131419DOI: 10.4049/jimmunol.1000222 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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