3NMQ
Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heat shock protein HSP 90-beta | polymer | 239 | 26686.1 | 1 | UniProt (P08238) Pfam (PF13589) | Homo sapiens (human) | HSP 90, Heat shock 84 kDa, HSP 84, HSP84 |
| 2 | B (A) | 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol | non-polymer | 413.9 | 1 | Chemie (7PP) | |||
| 3 | C (A) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 6 - 228 (UniProt: P08238)
| PDB | External Database | Details |
|---|---|---|
| Asp 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Thr 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gly 229 | - | expression tag |
| Glu 230 | - | expression tag |
| Phe 231 | - | expression tag |
| Asn 232 | - | expression tag |
| Ser 233 | - | expression tag |
| Lys 234 | - | expression tag |
| Leu 235 | - | expression tag |
| Gly 236 | - | expression tag |
| Cys 237 | - | expression tag |
| Phe 238 | - | expression tag |
| Gly 239 | - | expression tag |
| Gly 240 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26686.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 413.9 | |
| All* | Total formula weight | 27100.0 |
