2ER7
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![BU of 2er7 by Molmil](/molmil-images/mine/2er7) | X-RAY ANALYSES OF ASPARTIC PROTEINASES.III. THREE-DIMENSIONAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH A TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN AT 1.6 ANGSTROMS RESOLUTION | Descriptor: | ENDOTHIAPEPSIN, SULFATE ION, TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN | Authors: | Veerapandian, B, Cooper, J.B, Szelke, M, Blundell, T.L. | Deposit date: | 1990-11-12 | Release date: | 1991-01-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution. J.Mol.Biol., 216, 1990
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1AW5
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![BU of 1aw5 by Molmil](/molmil-images/mine/1aw5) | |
1B4E
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![BU of 1b4e by Molmil](/molmil-images/mine/1b4e) | X-ray structure of 5-aminolevulinic acid dehydratase complexed with the inhibitor levulinic acid | Descriptor: | GLYCEROL, LAEVULINIC ACID, PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE), ... | Authors: | Erskine, P.T, Cooper, J.B, Lewis, G, Spencer, P, Wood, S.P, Shoolingin-Jordan, P.M. | Deposit date: | 1998-12-19 | Release date: | 1999-12-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution. Biochemistry, 38, 1999
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1E51
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![BU of 1e51 by Molmil](/molmil-images/mine/1e51) | Crystal structure of native human erythrocyte 5-aminolaevulinic acid dehydratase | Descriptor: | 3-[5-(AMINOMETHYL)-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC ACID, DELTA-AMINOLEVULINIC ACID DEHYDRATASE, SULFATE ION, ... | Authors: | Mills-Davies, N.L, Thompson, D, Cooper, J.B, Shoolingin-Jordan, P.M. | Deposit date: | 2000-07-13 | Release date: | 2001-07-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | The Crystal Structure of Human Ala-Dehydratase To be Published
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1EB3
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![BU of 1eb3 by Molmil](/molmil-images/mine/1eb3) | YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 4,7-DIOXOSEBACIC ACID COMPLEX | Descriptor: | 4,7-DIOXOSEBACIC ACID, 5-AMINOLAEVULINIC ACID DEHYDRATASE, ZINC ION | Authors: | Erskine, P.T, Coates, L, Newbold, R, Brindley, A.A, Stauffer, F, Wood, S.P, Warren, M.J, Cooper, J.B, Shoolingin-Jordan, P.M, Neier, R. | Deposit date: | 2001-07-18 | Release date: | 2001-08-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The X-Ray Structure of Yeast 5-Aminolaevulinic Acid Dehydratase Complexed with Two Diacid Inhibitors FEBS Lett., 503, 2001
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2ER6
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![BU of 2er6 by Molmil](/molmil-images/mine/2er6) | The structure of a synthetic pepsin inhibitor complexed with endothiapepsin. | Descriptor: | ENDOTHIAPEPSIN, H-256 peptide | Authors: | Cooper, J.B, Foundling, S.I, Szelke, M, Blundell, T.L. | Deposit date: | 1990-10-13 | Release date: | 1991-01-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of a synthetic pepsin inhibitor complexed with endothiapepsin Eur.J.Biochem., 169, 1987
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7PJD
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![BU of 7pjd by Molmil](/molmil-images/mine/7pjd) | |
1SMR
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![BU of 1smr by Molmil](/molmil-images/mine/1smr) | |
5M6R
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![BU of 5m6r by Molmil](/molmil-images/mine/5m6r) | Human porphobilinogen deaminase in complex with reaction intermediate | Descriptor: | 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PHOSPHATE ION, ... | Authors: | Pluta, P, Millet, O, Roversi, P, Rojas, A.L, Gu, S. | Deposit date: | 2016-10-25 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Structural basis of pyrrole polymerization in human porphobilinogen deaminase. Biochim Biophys Acta Gen Subj, 1862, 2018
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5M7F
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![BU of 5m7f by Molmil](/molmil-images/mine/5m7f) | Human porphobilinogen deaminase in complex with DPM cofactor | Descriptor: | 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase, SULFATE ION | Authors: | Pluta, P, Millet, O, Roversi, P, Rojas, A.L, Gu, S. | Deposit date: | 2016-10-27 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Structural basis of pyrrole polymerization in human porphobilinogen deaminase. Biochim Biophys Acta Gen Subj, 1862, 2018
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3ER5
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![BU of 3er5 by Molmil](/molmil-images/mine/3er5) | THE ACTIVE SITE OF ASPARTIC PROTEINASES | Descriptor: | ENDOTHIAPEPSIN, H-189 | Authors: | Bailey, D, Veerapandian, B, Cooper, J, Szelke, M, Blundell, T.L. | Deposit date: | 1991-01-05 | Release date: | 1991-04-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin. Biochem.J., 289 ( Pt 2), 1993
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2C8S
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![BU of 2c8s by Molmil](/molmil-images/mine/2c8s) | CYTOCHROME CL FROM METHYLOBACTERIUM EXTORQUENS | Descriptor: | CALCIUM ION, CYTOCHROME C-L, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Williams, P.A, Coates, L, Mohammed, F, Gill, R, Erskine, P.T, Wood J, S.P, Cooper, B, Anthony, C. | Deposit date: | 2005-12-06 | Release date: | 2005-12-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The 1.6A X-Ray Structure of the Unusual C-Type Cytochrome, Cytochrome Cl, from the Methylotrophic Bacterium Methylobacterium Extorquens. J.Mol.Biol., 357, 2006
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4ER1
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![BU of 4er1 by Molmil](/molmil-images/mine/4er1) | THE ACTIVE SITE OF ASPARTIC PROTEINASES | Descriptor: | ENDOTHIAPEPSIN, N-[(1R,2R,4R)-1-(cyclohexylmethyl)-2-hydroxy-6-methyl-4-{[(2R)-2-methylbutyl]carbamoyl}heptyl]-3-(1H-imidazol-3-ium-4-yl)-N~2~-[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]-L-alaninamide | Authors: | Quail, J.W, Cooper, J.B, Szelke, M, Blundell, T.L. | Deposit date: | 1990-10-14 | Release date: | 1991-01-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The active site of aspartic proteinases FEBS Lett., 174, 1984
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1ENT
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![BU of 1ent by Molmil](/molmil-images/mine/1ent) | |
1U2E
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![BU of 1u2e by Molmil](/molmil-images/mine/1u2e) | Crystal Structure of the C-C bond hydrolase MhpC | Descriptor: | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase, CHLORIDE ION | Authors: | Montgomery, M.G, Dunn, G, Mohammed, F, Robertson, T, Garcia, J.-L, Coker, A, Bugg, T.D.H, Wood, S.P. | Deposit date: | 2004-07-19 | Release date: | 2005-02-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Structure of the C-C Bond Hydrolase MhpC Provides Insights into its Catalytic Mechanism J.Mol.Biol., 346, 2005
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2IPH
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![BU of 2iph by Molmil](/molmil-images/mine/2iph) | |
3EQ1
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![BU of 3eq1 by Molmil](/molmil-images/mine/3eq1) | The Crystal Structure of Human Porphobilinogen Deaminase at 2.8A resolution | Descriptor: | 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase, SULFATE ION | Authors: | Kolstoe, S.E, Gill, R, Mohammed, F, Wood, S.P. | Deposit date: | 2008-09-30 | Release date: | 2009-03-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria Biochem.J., 420, 2009
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3GFB
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![BU of 3gfb by Molmil](/molmil-images/mine/3gfb) | |
5NFE
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![BU of 5nfe by Molmil](/molmil-images/mine/5nfe) | Neutron structure of human transthyretin (TTR) T119M mutant at room temperature to 1.85A resolution | Descriptor: | Transthyretin | Authors: | Yee, A.W, Moulin, M, Blakeley, M.P, Ostermann, A, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. | Deposit date: | 2017-03-14 | Release date: | 2019-01-02 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.853 Å), X-RAY DIFFRACTION | Cite: | A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10, 2019
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5NFW
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![BU of 5nfw by Molmil](/molmil-images/mine/5nfw) | Neutron structure of human transthyretin (TTR) S52P mutant at room temperature to 1.8A resolution (quasi-Laue) | Descriptor: | Transthyretin | Authors: | Yee, A.W, Moulin, M, Blakeley, M.P, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. | Deposit date: | 2017-03-16 | Release date: | 2019-01-02 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION | Cite: | A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10, 2019
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1BBS
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![BU of 1bbs by Molmil](/molmil-images/mine/1bbs) | |
1B4K
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![BU of 1b4k by Molmil](/molmil-images/mine/1b4k) | High resolution crystal structure of a MG2-dependent 5-aminolevulinic acid dehydratase | Descriptor: | LAEVULINIC ACID, MAGNESIUM ION, PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE), ... | Authors: | Frankenberg, N, Jahn, D, Heinz, D.W. | Deposit date: | 1998-12-22 | Release date: | 1999-07-13 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase. J.Mol.Biol., 289, 1999
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1EED
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![BU of 1eed by Molmil](/molmil-images/mine/1eed) | X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors | Descriptor: | (2S)-2-[[(3S,4S)-5-cyclohexyl-4-[[(4S,5S)-5-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxidanyl-6-phenyl-hexanoyl]amino]-3-oxidanyl-pentanoyl]amino]-4-methyl-pentanoic acid, ENDOTHIAPEPSIN | Authors: | Blundell, T.L, Frazao, C, Cooper, J.B. | Deposit date: | 1992-06-15 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors. Biochemistry, 31, 1992
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6KTH
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![BU of 6kth by Molmil](/molmil-images/mine/6kth) | Crystal structure of Juvenile hormone diol kinase JHDK-L2 from silkworm, Bombyx mori | Descriptor: | CALCIUM ION, GLYCEROL, Juvenile hormone diol kinase | Authors: | Zhang, Y.S, Xu, H.Y, Wang, Z, Zhang, L, Zhao, P, Guo, P.C. | Deposit date: | 2019-08-28 | Release date: | 2020-09-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Structural characterization and functional analysis of juvenile hormone diol kinase from the silkworm, Bombyx mori. Int.J.Biol.Macromol., 167, 2021
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4APE
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![BU of 4ape by Molmil](/molmil-images/mine/4ape) | THE ACTIVE SITE OF ASPARTIC PROTEINASES | Descriptor: | ENDOTHIAPEPSIN | Authors: | Pearl, L.H, Sewell, B.T, Jenkins, J.A, Cooper, J.B, Blundell, T.L. | Deposit date: | 1986-06-09 | Release date: | 1986-07-14 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Active Site of Aspartic Proteinases FEBS Lett., 174, 1984
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