3EQ1

The Crystal Structure of Human Porphobilinogen Deaminase at 2.8A resolution

Summary for 3EQ1

DescriptorPorphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, SULFATE ION (3 entities in total)
Functional Keywordsalpha and beta protein, alternative splicing, cytoplasm, disease mutation, heme biosynthesis, porphyrin biosynthesis, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm (Probable) P08397
Total number of polymer chains2
Total molecular weight80221.16
Authors
Kolstoe, S.E.,Gill, R.,Mohammed, F.,Wood, S.P. (deposition date: 2008-09-30, release date: 2009-03-03, Last modification date: 2011-07-13)
Primary citation
Gill, R.,Kolstoe, S.E.,Mohammed, F.,Al D-Bass, A.,Mosely, J.E.,Sarwar, M.,Cooper, J.B.,Wood, S.P.,Shoolingin-Jordan, P.M.
Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria
Biochem.J., 420:17-25, 2009
PubMed: 19207107 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20082077
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2871005.0%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3eq1
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Molmil generated image of 3eq1
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Molmil generated image of 3eq1
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3eq1
no rotation
Molmil generated image of 3eq1
rotated about x axis by 90°
Molmil generated image of 3eq1
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3eq1.pdb2.gz [47.1 KB])
Coordinate files for Biological unit (3eq1.pdb1.gz [46.83 KB])
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