2IPH
X-ray Structure at 1.75 A Resolution of a Norovirus Protease Linked to an Active Site Directed Peptide Inhibitor
Summary for 2IPH
Entry DOI | 10.2210/pdb2iph/pdb |
Descriptor | Thiol protease P3C, N-ACETYL-L-ALPHA-GLUTAMYL-L-PHENYLALANYL-L-GLUTAMINYL-N-[(1S)-4-AMINO-1-(2-CARBOXYETHYL)-4-OXOBUTYL]-L-LEUCINAMIDE (3 entities in total) |
Functional Keywords | beta barrel, alpha helix, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Southampton virus (serotype 3) |
Total number of polymer chains | 2 |
Total formula weight | 40078.15 |
Authors | Hussey, R.J. (deposition date: 2006-10-12, release date: 2007-10-23, Last modification date: 2012-06-20) |
Primary citation | Hussey, R.J.,Coates, L.,Gill, R.S.,Erskine, P.T.,Coker, S.F.,Mitchell, E.,Cooper, J.B.,Wood, S.,Broadbridge, R.,Clarke, I.N.,Lambden, P.R.,Shoolingin-Jordan, P.M. A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor. Biochemistry, 50:240-249, 2011 Cited by PubMed: 21128685DOI: 10.1021/bi1008497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report