2IPH

X-ray Structure at 1.75 A Resolution of a Norovirus Protease Linked to an Active Site Directed Peptide Inhibitor

Summary for 2IPH

• Entry DOI: 10.2210/pdb2iph/pdb
• Descriptor: Thiol protease P3C, N-ACETYL-L-ALPHA-GLUTAMYL-L-PHENYLALANYL-L-GLUTAMINYL-N-[(1S)-4-AMINO-1-(2-CARBOXYETHYL)-4-OXOBUTYL]-L-LEUCINAMIDE (3 entities in total)
• Functional Keywords: beta barrel, alpha helix, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Southampton virus (serotype 3)
• Total number of polymer chains: 2
• Total formula weight: 40078.15

Authors

Hussey, R.J. (deposition date: 2006-10-12, release date: 2007-10-23, Last modification date: 2012-06-20)

• Primary citation: Hussey, R.J.,Coates, L.,Gill, R.S.,Erskine, P.T.,Coker, S.F.,Mitchell, E.,Cooper, J.B.,Wood, S.,Broadbridge, R.,Clarke, I.N.,Lambden, P.R.,Shoolingin-Jordan, P.M.; A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor.; Biochemistry, 50:240-249, 2011; PubMed: 21128685; DOI: 10.1021/bi1008497

Experimental method

X-RAY DIFFRACTION (1.75 Å)