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2IPH

X-ray Structure at 1.75 A Resolution of a Norovirus Protease Linked to an Active Site Directed Peptide Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0006508biological_processproteolysis
B0004197molecular_functioncysteine-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE LGG A 1
ChainResidue
AHIS1030
ACYS1139
AHIS1157
AALA1158
AALA1159
AALA1160
ATHR1161
ATHR1166
AVAL1168
AHOH1184
AHOH1195
AMET1107
AHOH1235
AHOH1243
AHOH1271
AHOH1275
AHOH1287
BSER2106
BMET2107
BARG2108
AILE1109
AGLN1110
AARG1112
ATHR1134
AILE1135
APRO1136
AGLY1137

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE LGG B 1
ChainResidue
BHIS2030
BILE2109
BGLN2110
BARG2112
BTHR2134
BILE2135
BPRO2136
BGLY2137
BCYS2139
BHIS2157
BALA2158
BALA2159
BALA2160
BTHR2161
BLYS2162
BTHR2166
BVAL2168
BHOH2192
BHOH2219
BHOH2225
BHOH2269
BHOH2285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870
ChainResidueDetails
AHIS1030
AGLU1054
ACYS1139
BHIS2030
BGLU2054
BCYS2139

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by 3CLpro
ChainResidueDetails
AGLU1181
BGLU2181

229380

PDB entries from 2024-12-25

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