3MJ7
| Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coxsackievirus and adenovirus receptor homolog, ... | Authors: | Verdino, P, Wilson, I.A. | Deposit date: | 2010-04-12 | Release date: | 2010-09-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science, 329, 2010
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8V08
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8VBJ
| Structure of bovine anti-HIV Fab ElsE2 | Descriptor: | Bovine Fab ElsE2 heavy chain, Bovine Fab ElsE2 light chain, POTASSIUM ION, ... | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBN
| Structure of bovine anti-HIV Fab ElsE8 | Descriptor: | Bovine Fab ElsE8 heavy chain, Bovine Fab ElsE8 light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBO
| Structure of bovine anti-HIV Fab ElsE9 | Descriptor: | Bovine Fab ElsE9 heavy chain, Bovine Fab ElsE9 light chain, GLYCEROL, ... | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBQ
| Structure of bovine anti-HIV Fab Bess7 | Descriptor: | Bovine Fab Bess7 heavy chain, Bovine Fab Bess7 light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8V4I
| Structure of bovine anti-HIV Fab ElsE1 | Descriptor: | ElsE1 Fab heavy chain, ElsE1 Fab light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-11-29 | Release date: | 2024-09-04 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultra-long CDRH3 repertoire To Be Published
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8VBL
| Structure of bovine anti-HIV Fab ElsE6 | Descriptor: | Bovine Fab ElsE6 heavy chain, Bovine Fab ElsE6 light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBM
| Structure of bovine anti-HIV Fab ElsE7 | Descriptor: | Bovine Fab ElsE7 heavy chain, Bovine Fab ElsE7 light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBP
| Structure of bovine anti-HIV Fab Bess4 | Descriptor: | Bovine Fab Bess4 heavy chain, Bovine Fab Bess4 light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBK
| Structure of bovine anti-HIV Fab ElsE5 | Descriptor: | Bovine Fab ElsE5 heavy chain, Bovine Fab ElsE5 light chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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8VBR
| Structure of bovine anti-HIV Fab ElsE11 | Descriptor: | Bovine Fab ElsE11 light chain, Bovine Fab Else11 heavy chain | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2023-12-12 | Release date: | 2024-09-04 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
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5FEH
| Crystal structure of PCT64_35B, a broadly neutralizing anti-HIV antibody | Descriptor: | 1,2-ETHANEDIOL, PCT64_26 Fab heavy chain, PCT64_26 Fab light chain, ... | Authors: | Murrell, S, Wilson, I.A. | Deposit date: | 2015-12-17 | Release date: | 2017-08-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47, 2017
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8VQL
| Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6S prime | Descriptor: | (S~1~S,3S)-N-{3,5-dichloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, T.H, Zhu, Y, Wilson, I.A. | Deposit date: | 2024-01-18 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VQQ
| Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6S | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... | Authors: | Lin, T.H, Zhu, Y, Wilson, I.A. | Deposit date: | 2024-01-19 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VQM
| Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6R prime | Descriptor: | (S~1~S,3R)-N-{3,5-dichloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, T.H, Zhu, Y, Wilson, I.A. | Deposit date: | 2024-01-18 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VQN
| Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6R | Descriptor: | (S~1~S,3R)-N-{3-chloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... | Authors: | Lin, T.H, Zhu, Y, Wilson, I.A. | Deposit date: | 2024-01-18 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc.Natl.Acad.Sci.USA, 121, 2024
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5HZQ
| Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate | Descriptor: | 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, Cellular retinoic acid-binding protein 2, GLYCEROL | Authors: | Chen, W, Mortenson, D.E, Wilson, I.A, Kelly, J.W. | Deposit date: | 2016-02-02 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. J.Am.Chem.Soc., 138, 2016
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6FYU
| Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Laursen, N.S, Wilson, I.A. | Deposit date: | 2018-03-12 | Release date: | 2018-11-07 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.643 Å) | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science, 362, 2018
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8V06
| Crystal structure of mouse PLD3 co-crystallized with 5'Pi-ssDNA for 9 days | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | Authors: | Yuan, M, Wilson, I.A. | Deposit date: | 2023-11-17 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. Structure, 32, 2024
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8V05
| Crystal structure of mouse PLD3 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | Deposit date: | 2023-11-17 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. Structure, 32, 2024
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8V07
| Crystal structure of mouse PLD3 co-crystallized with 5'Pi-ssDNA for 30 days | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | Authors: | Yuan, M, Wilson, I.A. | Deposit date: | 2023-11-17 | Release date: | 2024-03-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. Structure, 32, 2024
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6FYS
| Structure of single domain antibody SD83 | Descriptor: | 1,2-ETHANEDIOL, Single domain antibody SD83 | Authors: | Laursen, N.S, Wilson, I.A. | Deposit date: | 2018-03-12 | Release date: | 2018-11-07 | Last modified: | 2022-03-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science, 362, 2018
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6FYW
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6FYT
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