5IES

Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.16 A

Summary for 5IES

• Entry DOI: 10.2210/pdb5ies/pdb
• Related: 5IF0 5IFA
• Descriptor: VRC01cHuGL2 Fab heavy chain, VRC01cHuGL2 Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, ... (6 entities in total)
• Functional Keywords: hiv-1 gp120, engineered outer domain (eod), germline targeting, cd4 binding site, vrc01-class naive human germline antibody, immune system, viral-protein complex, immune system-viral protein complex, immune system- viral protein complex, immune system/ viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 68038.93

Authors

Sarkar, A.,Wilson, I.A. (deposition date: 2016-02-25, release date: 2016-04-06, Last modification date: 2023-09-27)

• Primary citation: Jardine, J.G.,Kulp, D.W.,Havenar-Daughton, C.,Sarkar, A.,Briney, B.,Sok, D.,Sesterhenn, F.,Ereno-Orbea, J.,Kalyuzhniy, O.,Deresa, I.,Hu, X.,Spencer, S.,Jones, M.,Georgeson, E.,Adachi, Y.,Kubitz, M.,deCamp, A.C.,Julien, J.P.,Wilson, I.A.,Burton, D.R.,Crotty, S.,Schief, W.R.; HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.; Science, 351:1458-1463, 2016; PubMed: 27013733; DOI: 10.1126/science.aad9195

Experimental method

X-RAY DIFFRACTION (2.16 Å)