5CD3
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![BU of 5cd3 by Molmil](/molmil-images/mine/5cd3) | Structure of immature VRC01-class antibody DRVIA7 | Descriptor: | DRVIA7 Heavy Chain, DRVIA7 Light Chain | Authors: | Kong, L, Wilson, I.A. | Deposit date: | 2015-07-02 | Release date: | 2016-04-06 | Last modified: | 2018-09-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor. Immunity, 44, 2016
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1F9H
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![BU of 1f9h by Molmil](/molmil-images/mine/1f9h) | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF E. COLI HPPK(R92A) WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.50 ANGSTROM RESOLUTION | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, CHLORIDE ION, ... | Authors: | Blaszczyk, J, Ji, X. | Deposit date: | 2000-07-10 | Release date: | 2003-04-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Dynamic Roles of Arginine Residues 82 and 92 of Escherichia coli
6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase: Crystallographic
Studies Biochemistry, 42, 2003
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1FG3
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![BU of 1fg3 by Molmil](/molmil-images/mine/1fg3) | CRYSTAL STRUCTURE OF L-HISTIDINOL PHOSPHATE AMINOTRANSFERASE COMPLEXED WITH L-HISTIDINOL | Descriptor: | HISTIDINOL PHOSPHATE AMINOTRANSFERASE, PHOSPHORIC ACID MONO-[2-AMINO-3-(3H-IMIDAZOL-4-YL)-PROPYL]ESTER, PYRIDOXAL-5'-PHOSPHATE | Authors: | Sivaraman, J, Cygler, M. | Deposit date: | 2000-07-27 | Release date: | 2001-08-22 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. J.Mol.Biol., 311, 2001
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5CD5
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![BU of 5cd5 by Molmil](/molmil-images/mine/5cd5) | |
8X43
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![BU of 8x43 by Molmil](/molmil-images/mine/8x43) | human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2 | Descriptor: | Calmodulin-1, N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Ma, D, Guo, J. | Deposit date: | 2023-11-15 | Release date: | 2024-01-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol., 20, 2024
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1G4C
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![BU of 1g4c by Molmil](/molmil-images/mine/1g4c) | |
6WAU
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![BU of 6wau by Molmil](/molmil-images/mine/6wau) | Complex structure of PHF19 | Descriptor: | Histone H3.1t peptide, PHD finger protein 19, UNKNOWN ATOM OR ION | Authors: | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2020-03-26 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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6WAV
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![BU of 6wav by Molmil](/molmil-images/mine/6wav) | Crystal structure of PHF1 in complex with H3K36me3 substitution | Descriptor: | Histone H3.1, PHD finger protein 1, SULFATE ION, ... | Authors: | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2020-03-26 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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6WAT
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![BU of 6wat by Molmil](/molmil-images/mine/6wat) | complex structure of PHF1 | Descriptor: | Histone H3.1t peptide, PHD finger protein 1, UNKNOWN ATOM OR ION | Authors: | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2020-03-26 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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1GZ0
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![BU of 1gz0 by Molmil](/molmil-images/mine/1gz0) | 23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB | Descriptor: | HYPOTHETICAL TRNA/RRNA METHYLTRANSFERASE YJFH | Authors: | Michel, G, Cygler, M. | Deposit date: | 2002-05-03 | Release date: | 2002-10-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Structure of the Rlmb 23S Rrna Methyltransferase Reveals a New Methyltransferase Fold with a Unique Knot Structure, 10, 2002
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4EML
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![BU of 4eml by Molmil](/molmil-images/mine/4eml) | |
1HN0
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![BU of 1hn0 by Molmil](/molmil-images/mine/1hn0) | |
1HSI
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![BU of 1hsi by Molmil](/molmil-images/mine/1hsi) | |
1HSG
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![BU of 1hsg by Molmil](/molmil-images/mine/1hsg) | |
1HQ2
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![BU of 1hq2 by Molmil](/molmil-images/mine/1hq2) | CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E.COLI HPPK(R82A) WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, ACETATE ION, ... | Authors: | Blaszczyk, J, Ji, X. | Deposit date: | 2000-12-13 | Release date: | 2003-04-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Dynamic Roles of Arginine Residues 82 and 92 of Escherichia coli
6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase: Crystallographic
Studies Biochemistry, 42, 2003
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4J3J
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![BU of 4j3j by Molmil](/molmil-images/mine/4j3j) | Crystal Structure of DPP-IV with Compound C3 | Descriptor: | Dipeptidyl peptidase 4, N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide | Authors: | Xiong, B, Zhu, L.R, Chen, D.Q, Zhao, Y.L, Jiang, F, Shen, J.K. | Deposit date: | 2013-02-05 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors Chemmedchem, 8, 2013
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1A2Y
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![BU of 1a2y by Molmil](/molmil-images/mine/1a2y) | HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 | Descriptor: | IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN), LYSOZYME, ... | Authors: | Tsuchiya, D, Mariuzza, R.A. | Deposit date: | 1998-01-13 | Release date: | 1998-04-29 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A mutational analysis of binding interactions in an antigen-antibody protein-protein complex. Biochemistry, 37, 1998
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2PL5
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![BU of 2pl5 by Molmil](/molmil-images/mine/2pl5) | Crystal Structure of Homoserine O-acetyltransferase from Leptospira interrogans | Descriptor: | GLYCEROL, Homoserine O-acetyltransferase | Authors: | Liu, L, Wang, M, Wang, Y, Wei, Z, Xu, H, Gong, W. | Deposit date: | 2007-04-19 | Release date: | 2007-11-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of homoserine O-acetyltransferase from Leptospira interrogans Biochem.Biophys.Res.Commun., 363, 2007
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2QX0
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![BU of 2qx0 by Molmil](/molmil-images/mine/2qx0) | Crystal Structure of Yersinia pestis HPPK (Ternary Complex) | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Blaszczyk, J, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | Deposit date: | 2007-08-10 | Release date: | 2007-10-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and activity of Yersinia pestis 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as a novel target for the development of antiplague therapeutics. Acta Crystallogr.,Sect.D, 63, 2007
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7JM5
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![BU of 7jm5 by Molmil](/molmil-images/mine/7jm5) | Crystal structure of KDM4B in complex with QC6352 | Descriptor: | 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid, Lysine-specific demethylase 4B, NICKEL (II) ION, ... | Authors: | White, S.W, Yun, M. | Deposit date: | 2020-07-31 | Release date: | 2022-02-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med, 14, 2022
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6PKA
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7KXT
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![BU of 7kxt by Molmil](/molmil-images/mine/7kxt) | Crystal structure of human EED | Descriptor: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION | Authors: | Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2020-12-04 | Release date: | 2021-02-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64, 2021
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6PMD
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![BU of 6pmd by Molmil](/molmil-images/mine/6pmd) | |
5GXH
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![BU of 5gxh by Molmil](/molmil-images/mine/5gxh) | The structure of the Gemin5 WD40 domain with AAUUUUUG | Descriptor: | GLYCEROL, Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*G)-3'), ... | Authors: | Xu, C, He, H, Li, Y, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2016-09-17 | Release date: | 2016-10-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly Genes Dev., 30, 2016
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6M63
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![BU of 6m63 by Molmil](/molmil-images/mine/6m63) | Crystal structure of a cAMP sensor G-Flamp1. | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein | Authors: | Zhou, Z, Chen, S, Wang, L, Chu, J. | Deposit date: | 2020-03-12 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging. Nat Commun, 13, 2022
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