2PJD
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![BU of 2pjd by Molmil](/molmil-images/mine/2pjd) | Crystal structure of 16S rRNA methyltransferase RsmC | Descriptor: | Ribosomal RNA small subunit methyltransferase C | Authors: | Sunita, S, Purta, E, Durawa, M, Tkaczuk, K.L, Bujnicki, J.M, Sivaraman, J. | Deposit date: | 2007-04-16 | Release date: | 2007-07-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC Nucleic Acids Res., 35, 2007
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1NPZ
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![BU of 1npz by Molmil](/molmil-images/mine/1npz) | Crystal structures of Cathepsin S inhibitor complexes | Descriptor: | Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide | Authors: | Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Seddon, A.P, Menard, R, Cygler, M, Rath, V.L. | Deposit date: | 2003-01-20 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Specificity determinants of human cathepsin s revealed
by crystal structures of complexes. Biochemistry, 42, 2003
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4HEX
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![BU of 4hex by Molmil](/molmil-images/mine/4hex) | |
1NQC
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![BU of 1nqc by Molmil](/molmil-images/mine/1nqc) | Crystal structures of Cathepsin S inhibitor complexes | Descriptor: | Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE | Authors: | Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Menard, R, Cygler, M, Rath, V.L. | Deposit date: | 2003-01-21 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Specificity determinants of human cathepsin s revealed
by crystal structures of complexes. Biochemistry, 42, 2003
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4KT5
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![BU of 4kt5 by Molmil](/molmil-images/mine/4kt5) | |
1MHW
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![BU of 1mhw by Molmil](/molmil-images/mine/1mhw) | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides | Descriptor: | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L | Authors: | Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O. | Deposit date: | 2002-08-21 | Release date: | 2002-12-11 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides J.Med.Chem., 45, 2002
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3RKD
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![BU of 3rkd by Molmil](/molmil-images/mine/3rkd) | |
3BUX
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![BU of 3bux by Molmil](/molmil-images/mine/3bux) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | Descriptor: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUM
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![BU of 3bum by Molmil](/molmil-images/mine/3bum) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 | Descriptor: | E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2 | Authors: | Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUW
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![BU of 3buw by Molmil](/molmil-images/mine/3buw) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | Descriptor: | 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3RJ2
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![BU of 3rj2 by Molmil](/molmil-images/mine/3rj2) | |
3RKC
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![BU of 3rkc by Molmil](/molmil-images/mine/3rkc) | |
3BUO
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![BU of 3buo by Molmil](/molmil-images/mine/3buo) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' | Descriptor: | 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUN
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![BU of 3bun by Molmil](/molmil-images/mine/3bun) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | Descriptor: | 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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5XWE
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![BU of 5xwe by Molmil](/molmil-images/mine/5xwe) | Structure of a three finger toxin from Ophiophagus hannah venom | Descriptor: | CHLORIDE ION, GLYCEROL, Weak toxin DE-1 homolog 1, ... | Authors: | Jobichen, C, Roy, A, Kini, R.M, Sivaraman, J. | Deposit date: | 2017-06-29 | Release date: | 2018-07-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of a three finger toxin from Ophiophagus hannah venom To Be Published
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5YDX
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![BU of 5ydx by Molmil](/molmil-images/mine/5ydx) | |
5YDY
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![BU of 5ydy by Molmil](/molmil-images/mine/5ydy) | |
3VP3
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![BU of 3vp3 by Molmil](/molmil-images/mine/3vp3) | Crystal structure of human glutaminase in complex with inhibitor 3 | Descriptor: | 5,5'-pentane-1,5-diylbis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial, ... | Authors: | Thangavelu, K, Sivaraman, J. | Deposit date: | 2012-02-23 | Release date: | 2012-06-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3VTS
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![BU of 3vts by Molmil](/molmil-images/mine/3vts) | |
3VP1
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![BU of 3vp1 by Molmil](/molmil-images/mine/3vp1) | |
3VP4
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![BU of 3vp4 by Molmil](/molmil-images/mine/3vp4) | Crystal structure of human glutaminase in complex with inhibitor 4 | Descriptor: | 5,5'-butane-1,4-diylbis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial | Authors: | Thangavelu, K, Sivaraman, J. | Deposit date: | 2012-02-23 | Release date: | 2012-06-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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4RUD
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![BU of 4rud by Molmil](/molmil-images/mine/4rud) | Crystal structure of a three finger toxin | Descriptor: | Three-finger toxin 3b, ZINC ION | Authors: | Jobichen, C, Sivaraman, J. | Deposit date: | 2014-11-18 | Release date: | 2016-05-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. Br.J.Pharmacol., 177, 2020
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3EBK
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![BU of 3ebk by Molmil](/molmil-images/mine/3ebk) | Crystal structure of major allergens, Bla g 4 from cockroaches | Descriptor: | Allergen Bla g 4 | Authors: | Tan, Y.W, Chan, S.L, Chew, F.T, Sivaraman, J, Mok, Y.K. | Deposit date: | 2008-08-28 | Release date: | 2008-12-02 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes. J.Biol.Chem., 284, 2008
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3ELP
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![BU of 3elp by Molmil](/molmil-images/mine/3elp) | Structure of cystationine gamma lyase | Descriptor: | Cystathionine gamma-lyase | Authors: | Sun, Q, Sivaraman, J. | Deposit date: | 2008-09-23 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S J.Biol.Chem., 284, 2009
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1K75
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![BU of 1k75 by Molmil](/molmil-images/mine/1k75) | The L-histidinol dehydrogenase (hisD) structure implicates domain swapping and gene duplication. | Descriptor: | GLYCEROL, L-histidinol dehydrogenase, SULFATE ION | Authors: | Barbosa, J.A.R.G, Sivaraman, J, Li, Y, Larocque, R, Matte, A, Schrag, J, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2001-10-18 | Release date: | 2002-02-27 | Last modified: | 2014-11-12 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase. Proc.Natl.Acad.Sci.USA, 99, 2002
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