4RUD

Crystal structure of a three finger toxin

Summary for 4RUD

• Entry DOI: 10.2210/pdb4rud/pdb
• Descriptor: Three-finger toxin 3b, ZINC ION (3 entities in total)
• Functional Keywords: three finger toxin, snake venom toxin, toxin
• Biological source: Micrurus fulvius (harlequin coralsnake)
• Total number of polymer chains: 2
• Total formula weight: 13217.79

Authors

Jobichen, C.,Sivaraman, J. (deposition date: 2014-11-18, release date: 2016-05-18, Last modification date: 2024-11-13)

Primary citation

Foo, C.S.,Jobichen, C.,Hassan-Puttaswamy, V.,Dekan, Z.,Tae, H.S.,Bertrand, D.,Adams, D.J.,Alewood, P.F.,Sivaraman, J.,Nirthanan, S.,Kini, R.M.
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.
Br.J.Pharmacol., 177:1822-1840, 2020

PubMed Abstract: Animal toxins have contributed significantly to our understanding of the neurobiology of receptors and ion channels. We studied the venom of the coral snake Micrurus fulvius fulvius and identified and characterized the structure and pharmacology of a new homodimeric neurotoxin, fulditoxin, that exhibited novel pharmacology at nicotinic ACh receptors (nAChRs).

PubMed: 31877243
DOI: 10.1111/bph.14954

Experimental method

X-RAY DIFFRACTION (1.95 Å)