4X8B
 
 | | Ergothioneine-biosynthetic sulfoxide synthase EgtB, apo form | | Descriptor: | CALCIUM ION, CHLORIDE ION, FE (III) ION, ... | | Authors: | Vit, A, Goncharenko, K.V, Blankenfeldt, W, Seebeck, F.P. | | Deposit date: | 2014-12-10 | | Release date: | 2015-01-28 | | Last modified: | 2017-09-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4X8D
 | | Ergothioneine-biosynthetic sulfoxide synthase EgtB in complex with N,N-dimethyl-histidine and gamma-glutamyl-cysteine | | Descriptor: | CALCIUM ION, CHLORIDE ION, GAMMA-GLUTAMYLCYSTEINE, ... | | Authors: | Vit, A, Goncharenko, K.V, Blankenfeldt, W, Seebeck, F.P. | | Deposit date: | 2014-12-10 | | Release date: | 2015-01-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4X8E
 | | Ergothioneine-biosynthetic sulfoxide synthase EgtB in complex with N,N,N-trimethyl-histidine | | Descriptor: | CALCIUM ION, CHLORIDE ION, FE (III) ION, ... | | Authors: | Vit, A, Goncharenko, K.V, Blankenfeldt, W, Seebeck, F.P. | | Deposit date: | 2014-12-10 | | Release date: | 2015-01-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4ZFL
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8BTJ
 | | Murine cytomegalovirus protein M35 | | Descriptor: | (R,R)-2,3-BUTANEDIOL, MALONATE ION, Protein M35 | | Authors: | Schmelz, S, Van den Heuvel, J, Blankenfeldt, W. | | Deposit date: | 2022-11-29 | | Release date: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | The Cytomegalovirus M35 Protein Directly Binds to the Interferon-beta Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes.
J.Virol., 97, 2023
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8CIZ
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Mycoplanecin A. | | Descriptor: | Beta sliding clamp, Mycoplanecin A | | Authors: | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | Deposit date: | 2023-02-11 | | Release date: | 2023-11-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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8CIY
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Cyclohexyl-Griselimycin. | | Descriptor: | ACETATE ION, Beta sliding clamp, CALCIUM ION, ... | | Authors: | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | Deposit date: | 2023-02-11 | | Release date: | 2023-11-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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8CIX
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Griselimycin. | | Descriptor: | ACETATE ION, Beta sliding clamp, CALCIUM ION, ... | | Authors: | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | Deposit date: | 2023-02-11 | | Release date: | 2023-11-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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3EX9
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3DZL
 | | Crystal structure of PhzA/B from Burkholderia cepacia R18194 in complex with (R)-3-oxocyclohexanecarboxylic acid | | Descriptor: | (1R)-3-oxocyclohexanecarboxylic acid, Phenazine biosynthesis protein A/B | | Authors: | Ahuja, E.G, Mentel, M, Graebsch, A, Breinbauer, R, Blankenfeldt, W. | | Deposit date: | 2008-07-30 | | Release date: | 2008-12-30 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | PhzA/B Catalyzes the Formation of the Tricycle in Phenazine Biosynthesis.
J.Am.Chem.Soc., 130, 2008
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3CNM
 | | Crystal Structure of Phenazine Biosynthesis Protein PhzA/B from Burkholderia cepacia R18194, DHHA complex | | Descriptor: | (2S,3S)-TRANS-2,3-DIHYDRO-3-HYDROXYANTHRANILIC ACID, ACETATE ION, Phenazine biosynthesis protein A/B | | Authors: | Ahuja, E.G, Blankenfeldt, W. | | Deposit date: | 2008-03-26 | | Release date: | 2008-12-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis.
J.Am.Chem.Soc., 130, 2008
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3C72
 | | Engineered RabGGTase in complex with a peptidomimetic inhibitor | | Descriptor: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | | Authors: | Guo, Z, Wu, Y.W, Tan, K.T, Bon, R.S, Guiu-Rozas, E, Delon, C, Nguyen, U.T, Wetzel, S, Arndt, S, Goody, R.S, Blankenfeldt, W, Alexandrov, K, Waldmann, H. | | Deposit date: | 2008-02-06 | | Release date: | 2008-07-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.
Angew.Chem.Int.Ed.Engl., 47, 2008
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2Q0I
 | | Structure of Pseudomonas Quinolone Signal Response Protein PqsE | | Descriptor: | BENZOIC ACID, FE (III) ION, Quinolone signal response protein | | Authors: | Yu, S, Jensen, V, Feldmann, I, Haussler, S, Blankenfeldt, W. | | Deposit date: | 2007-05-22 | | Release date: | 2008-06-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
Biochemistry, 48, 2009
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2Q0J
 | | Structure of Pseudomonas Quinolone Signal Response Protein PqsE | | Descriptor: | BENZOIC ACID, FE (III) ION, Quinolone signal response protein | | Authors: | Yu, S, Jensen, V, Feldmann, I, Haussler, S, Blankenfeldt, W. | | Deposit date: | 2007-05-22 | | Release date: | 2008-06-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
Biochemistry, 48, 2009
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5O16
 | | Crystal structure of bifunctional dehydratase-cyclase domain in ambruticin biosynthesis | | Descriptor: | AmbC, SULFATE ION | | Authors: | Sung, K.H, Berkhan, G, Hollmann, T, Wagner, L, Hahn, F, Blankenfeldt, W. | | Deposit date: | 2017-05-18 | | Release date: | 2017-11-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.745 Å) | | Cite: | Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain.
Angew. Chem. Int. Ed. Engl., 57, 2018
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3NKV
 | | Crystal structure of Rab1b covalently modified with AMP at Y77 | | Descriptor: | ADENOSINE MONOPHOSPHATE, BARIUM ION, MAGNESIUM ION, ... | | Authors: | Mueller, M.P, Peters, H, Blankenfeldt, W, Goody, R.S, Itzen, A. | | Deposit date: | 2010-06-21 | | Release date: | 2010-08-04 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.
Science, 329, 2010
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3NKU
 | | Crystal structure of the N-terminal domain of DrrA/SidM from Legionella pneumophila | | Descriptor: | DI(HYDROXYETHYL)ETHER, DrrA, TRIETHYLENE GLYCOL | | Authors: | Mueller, M.P, Peters, H, Blankenfeldt, W, Goody, R.S, Itzen, A. | | Deposit date: | 2010-06-21 | | Release date: | 2010-08-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.
Science, 329, 2010
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3N6O
 | | Crystal structure of the GEF and P4M domain of DrrA/SidM from Legionella pneumophila | | Descriptor: | SULFATE ION, guanine nucleotide exchange factor | | Authors: | Schoebel, S, Blankenfeldt, W, Goody, R.S, Itzen, A. | | Deposit date: | 2010-05-26 | | Release date: | 2010-07-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA.
Embo Rep., 11, 2010
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5O15
 | | Crystal structure of bifunctional dehydratase-cyclase domain in ambruticin biosynthesis | | Descriptor: | AmbC, GLYCEROL | | Authors: | Sung, K.H, Berkhan, G, Hollmann, T, Wagner, L, Hahn, F, Blankenfeldt, W. | | Deposit date: | 2017-05-18 | | Release date: | 2017-11-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.174 Å) | | Cite: | Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain.
Angew. Chem. Int. Ed. Engl., 57, 2018
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5O30
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6TD9
 | | X-ray structure of mature PA1624 from Pseudomonas aeruginosa PAO1 | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PA1624, ... | | Authors: | Feiler, C.G, Blankenfeldt, W. | | Deposit date: | 2019-11-08 | | Release date: | 2019-12-04 | | Last modified: | 2020-12-16 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure.
Acta Crystallogr.,Sect.F, 76, 2020
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6TCB
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6TPO
 | | Conformation of cd1 nitrite reductase NirS without bound heme d1 | | Descriptor: | (R,R)-2,3-BUTANEDIOL, HEME C, Nitrite reductase, ... | | Authors: | Kluenemann, T, Blankenfeldt, W. | | Deposit date: | 2019-12-13 | | Release date: | 2020-11-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.861 Å) | | Cite: | Structure of heme d 1 -free cd 1 nitrite reductase NirS.
Acta Crystallogr.,Sect.F, 76, 2020
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6TO2
 | | Crystal structure of CYP154C5 from Nocardia farcinica in complex with 5alpha-Androstan-3-one | | Descriptor: | (5~{S},8~{S},9~{S},10~{S},13~{S},14~{S})-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one, CHLORIDE ION, Cytochrome P450 monooxygenase, ... | | Authors: | Rodriguez, A, Kluenemann, T, Blankenfeldt, W, Schallmey, A. | | Deposit date: | 2019-12-11 | | Release date: | 2020-11-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering*.
Chembiochem, 22, 2021
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6TP9
 | | c-type cytochrome NirC | | Descriptor: | Cytochrome c55X, HEME C | | Authors: | Kluenemann, T, Henke, S, Blankenfeldt, W. | | Deposit date: | 2019-12-12 | | Release date: | 2020-04-22 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | The crystal structure of the heme d1biosynthesis-associated small c-type cytochrome NirC reveals mixed oligomeric states in crystallo.
Acta Crystallogr D Struct Biol, 76, 2020
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