6TO2

Crystal structure of CYP154C5 from Nocardia farcinica in complex with 5alpha-Androstan-3-one

Summary for 6TO2

• Entry DOI: 10.2210/pdb6to2/pdb
• Descriptor: Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (5~{S},8~{S},9~{S},10~{S},13~{S},14~{S})-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one, ... (5 entities in total)
• Functional Keywords: cytochrome p450, steroid hydroxylating monooxygenase, steroid binding, oxidoreductase-substrate complex, oxidoreductase
• Biological source: Nocardia farcinica IFM 10152
• Total number of polymer chains: 2
• Total formula weight: 92291.98

Authors

Rodriguez, A.,Kluenemann, T.,Blankenfeldt, W.,Schallmey, A. (deposition date: 2019-12-11, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Bracco, P.,Wijma, H.J.,Nicolai, B.,Buitrago, J.A.R.,Klunemann, T.,Vila, A.,Schrepfer, P.,Blankenfeldt, W.,Janssen, D.B.,Schallmey, A.; CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering*.; Chembiochem, 22:1099-1110, 2021; PubMed: 33145893; DOI: 10.1002/cbic.202000735

Experimental method

X-RAY DIFFRACTION (2 Å)