Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2NWZ
DownloadVisualize
BU of 2nwz by Molmil
Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWP
DownloadVisualize
BU of 2nwp by Molmil
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWO
DownloadVisualize
BU of 2nwo by Molmil
Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXS
DownloadVisualize
BU of 2nxs by Molmil
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWY
DownloadVisualize
BU of 2nwy by Molmil
Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor: ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2OSM
DownloadVisualize
BU of 2osm by Molmil
Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
Descriptor: 2-MERCAPTOPHENOL, Carbonic anhydrase 2, ZINC ION
Authors:Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-Mckenna, M, McKenna, R, Tripp, B.C.
Deposit date:2007-02-06
Release date:2008-02-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study.
Biochemistry, 47, 2008
2P4K
DownloadVisualize
BU of 2p4k by Molmil
Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Perry, J.J.
Deposit date:2007-03-12
Release date:2007-04-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
Biochemistry, 48, 2009
2NXR
DownloadVisualize
BU of 2nxr by Molmil
Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXT
DownloadVisualize
BU of 2nxt by Molmil
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
3GZ0
DownloadVisualize
BU of 3gz0 by Molmil
Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Avvaru, B.S, McKenna, R.
Deposit date:2009-04-06
Release date:2009-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Apo-Human Carbonic Anhydrase II Revisited: Implications of the Loss of a Metal in Protein Structure, Stability, and Solvent Network .
Biochemistry, 48, 2009
2OSF
DownloadVisualize
BU of 2osf by Molmil
Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
Descriptor: 4-MERCAPTOBENZENE-1,3-DIOL, Carbonic anhydrase 2, S-(2,4-dihydroxyphenyl) hydrogen thiocarbonate, ...
Authors:Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-McKenna, M, McKenna, R, Tripp, B.C.
Deposit date:2007-02-05
Release date:2008-05-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Biochemistry, 47, 2008
3KKX
DownloadVisualize
BU of 3kkx by Molmil
Neutron structure of human carbonic anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z, Langan, P.A.
Deposit date:2009-11-06
Release date:2010-01-12
Last modified:2023-09-06
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Neutron structure of human carbonic anhydrase II: implications for proton transfer.
Biochemistry, 49, 2010
4HBA
DownloadVisualize
BU of 4hba by Molmil
Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond
Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:Boone, C.D, Habibzadegan, A, McKenna, R.
Deposit date:2012-09-27
Release date:2013-07-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.762 Å)
Cite:Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond.
Acta Crystallogr.,Sect.D, 69, 2013
4HEY
DownloadVisualize
BU of 4hey by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor: 4-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
Authors:Aggarwal, M, McKenna, R.
Deposit date:2012-10-04
Release date:2013-10-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4HEW
DownloadVisualize
BU of 4hew by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor: 2-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
Authors:Aggarwal, M, McKenna, R.
Deposit date:2012-10-04
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6984 Å)
Cite:Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4IDR
DownloadVisualize
BU of 4idr by Molmil
Human Carbonic Anhydrase II Proton Transfer Double Mutant
Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:Mikulski, R.M, West, D.M.
Deposit date:2012-12-13
Release date:2012-12-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II.
Biochemistry, 52, 2013
4GL1
DownloadVisualize
BU of 4gl1 by Molmil
Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:West, D.M.
Deposit date:2012-08-13
Release date:2013-09-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Hydrophobicity and low pKa impact catalytic efficiency of Human Carbonic Anhydrases
To be Published
4HF3
DownloadVisualize
BU of 4hf3 by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor: Carbonic anhydrase 2, IMIDAZOLE, ZINC ION
Authors:Aggarwal, M, McKenna, R.
Deposit date:2012-10-04
Release date:2013-10-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.1476 Å)
Cite:Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4HEZ
DownloadVisualize
BU of 4hez by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor: 1-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
Authors:Aggarwal, M, McKenna, R.
Deposit date:2012-10-04
Release date:2013-10-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3446 Å)
Cite:Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4G0C
DownloadVisualize
BU of 4g0c by Molmil
Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z, McKenna, R, Aggarwal, M.
Deposit date:2012-07-09
Release date:2012-09-19
Last modified:2023-09-13
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.
J.Am.Chem.Soc., 134, 2012
3D8W
DownloadVisualize
BU of 3d8w by Molmil
Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Descriptor: 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase II, ZINC ION
Authors:Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
Deposit date:2008-05-26
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DBU
DownloadVisualize
BU of 3dbu by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Descriptor: 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
Authors:Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
Deposit date:2008-06-02
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DD0
DownloadVisualize
BU of 3dd0 by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Descriptor: 6-ethoxy-1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
Authors:Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
Deposit date:2008-06-04
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DVD
DownloadVisualize
BU of 3dvd by Molmil
X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Avvaru, B.S.
Deposit date:2008-07-18
Release date:2008-11-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008
3DVB
DownloadVisualize
BU of 3dvb by Molmil
X-ray crystal structure of mutant N62V human Carbonic Anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Avvaru, B.S.
Deposit date:2008-07-18
Release date:2008-11-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008

224572

PDB entries from 2024-09-04

PDB statisticsPDBj update infoContact PDBjnumon