2NXS

Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II

Summary for 2NXS

Entry DOI	10.2210/pdb2nxs/pdb
Related	2NWO 2NWP 2NWY 2NXR 2NXT 2NXZ
Descriptor	carbonic anhydrase 2, ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	proton transfer, histidine 64, carbonic anhydrase, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29434.53
Authors	Fisher, S.Z.,McKenna, R. (deposition date: 2006-11-19, release date: 2007-04-24, Last modification date: 2023-08-30)
Primary citation	Fisher, S.Z.,Tu, C.K.,Bhatt, D.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Silverman, D.N. Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46:3803-3813, 2007 Cited by PubMed: 17330962 DOI: 10.1021/bi602620k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation