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2NWY

Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II

Summary for 2NWY
Entry DOI10.2210/pdb2nwy/pdb
Related2NWO 2NWP 2NWZ 2NXR 2NXS 2NXT
Descriptorcarbonic anhydrase 2, ZINC ION (3 entities in total)
Functional Keywordsproton transfer, histidine 64, carbonic anhydrase, lyase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P00918
Total number of polymer chains1
Total formula weight29353.53
Authors
Fisher, S.Z.,McKenna, R. (deposition date: 2006-11-16, release date: 2007-04-24, Last modification date: 2023-08-30)
Primary citationFisher, S.Z.,Tu, C.K.,Bhatt, D.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Silverman, D.N.
Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46:3803-3813, 2007
Cited by
PubMed: 17330962
DOI: 10.1021/bi602620k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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