2OSF
Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
Summary for 2OSF
Entry DOI | 10.2210/pdb2osf/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-MERCAPTOBENZENE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase ii, thioxolone, therapeutic ca inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29551.63 |
Authors | Albert, A.B.,Caroli, G.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C. (deposition date: 2007-02-05, release date: 2008-05-27, Last modification date: 2023-08-30) |
Primary citation | Barrese, A.A.,Genis, C.,Fisher, S.Z.,Orwenyo, J.N.,Kumara, M.T.,Dutta, S.K.,Phillips, E.,Kiddle, J.J.,Tu, C.,Silverman, D.N.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C. Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry, 47:3174-3184, 2008 Cited by PubMed: 18266323DOI: 10.1021/bi702385k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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