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2OSF

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study

Summary for 2OSF
Entry DOI10.2210/pdb2osf/pdb
DescriptorCarbonic anhydrase 2, ZINC ION, 4-MERCAPTOBENZENE-1,3-DIOL, ... (5 entities in total)
Functional Keywordscarbonic anhydrase ii, thioxolone, therapeutic ca inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P00918
Total number of polymer chains1
Total formula weight29551.63
Authors
Albert, A.B.,Caroli, G.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C. (deposition date: 2007-02-05, release date: 2008-05-27, Last modification date: 2023-08-30)
Primary citationBarrese, A.A.,Genis, C.,Fisher, S.Z.,Orwenyo, J.N.,Kumara, M.T.,Dutta, S.K.,Phillips, E.,Kiddle, J.J.,Tu, C.,Silverman, D.N.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C.
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Biochemistry, 47:3174-3184, 2008
Cited by
PubMed: 18266323
DOI: 10.1021/bi702385k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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