1K1U
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![BU of 1k1u by Molmil](/molmil-images/mine/1k1u) | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance | Descriptor: | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN | Authors: | Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, W Harrison, R, Weber, I.T. | Deposit date: | 2001-09-25 | Release date: | 2002-07-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Combining mutations in HIV-1 protease to understand mechanisms of resistance. Proteins, 48, 2002
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2MS4
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![BU of 2ms4 by Molmil](/molmil-images/mine/2ms4) | Cyclophilin a complexed with a fragment of crk-ii | Descriptor: | Peptide, Peptidyl-prolyl cis-trans isomerase A | Authors: | Jankowski, W, Saleh, T, Rossi, P, Kalodimos, C. | Deposit date: | 2014-07-22 | Release date: | 2015-09-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway. Nat.Chem.Biol., 12, 2016
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2NNP
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![BU of 2nnp by Molmil](/molmil-images/mine/2nnp) | Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ACETIC ACID, GLYCEROL, ... | Authors: | Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2006-10-24 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67, 2007
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2NMZ
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![BU of 2nmz by Molmil](/molmil-images/mine/2nmz) | Crystal structure analysis of HIV-1 protease mutant V82A with a inhibitor saquinavir | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, PROTEASE, SULFATE ION | Authors: | Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2006-10-23 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67, 2007
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2NNK
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![BU of 2nnk by Molmil](/molmil-images/mine/2nnk) | Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ACETIC ACID, CHLORIDE ION, ... | Authors: | Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2006-10-24 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67, 2007
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2NMY
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![BU of 2nmy by Molmil](/molmil-images/mine/2nmy) | Crystal structure analysis of HIV-1 protease mutant V82A with a inhibitor saquinavir | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, PROTEASE, ... | Authors: | Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2006-10-23 | Release date: | 2007-03-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67, 2007
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2OA4
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![BU of 2oa4 by Molmil](/molmil-images/mine/2oa4) | Solution NMR Structure: Northeast Structural Genomics Consortium Target SiR5 | Descriptor: | SiR5 | Authors: | Wang, L, Rossi, P, Chen, C.X, Nwosu, C, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Burkhard, R, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-12-14 | Release date: | 2007-03-06 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target SiR5 To be Published
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2K1G
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![BU of 2k1g by Molmil](/molmil-images/mine/2k1g) | Solution NMR structure of lipoprotein spr from Escherichia coli K12. Northeast Structural Genomics target ER541-37-162 | Descriptor: | Lipoprotein spr | Authors: | Aramini, J.M, Rossi, P, Zhao, L, Jiang, M, Maglaqui, M, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Huang, Y.J, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-03-03 | Release date: | 2008-03-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the NlpC/P60 domain of lipoprotein Spr from Escherichia coli: structural evidence for a novel cysteine peptidase catalytic triad. Biochemistry, 47, 2008
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2JVW
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![BU of 2jvw by Molmil](/molmil-images/mine/2jvw) | Solution NMR structure of uncharacterized protein Q5E7H1 from Vibrio fischeri. Northeast Structural Genomics target VfR117 | Descriptor: | Uncharacterized protein | Authors: | Aramini, J.M, Rossi, P, Wang, D, Nwosu, C, Owens, L.A, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-09-26 | Release date: | 2007-10-16 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of VF0530 from Vibrio fischeri reveals a nucleic acid-binding function. Proteins, 79, 2011
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2JRF
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![BU of 2jrf by Molmil](/molmil-images/mine/2jrf) | Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. Northeast Structural Genomics target HR387. | Descriptor: | Tubulin polymerization-promoting protein family member 3 | Authors: | Aramini, J.M, Rossi, P, Shastry, R, Nwosu, C, Cunningham, K, Xiao, R, Liu, J, Baran, M.C, Rajan, P.K, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-25 | Release date: | 2007-07-17 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. To be Published
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2K5W
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![BU of 2k5w by Molmil](/molmil-images/mine/2k5w) | Solution NMR Structure of Putative Lipoprotein from Bacillus cereus Ordered Locus BC_2438. Northeast Structural Genomics Target BcR103A. | Descriptor: | Hypothetical Cytosolic Protein BcR103A | Authors: | Conover, K.M, Swapna, G, Rossi, P, Wang, D, Janjua, H, Owens, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-06-30 | Release date: | 2008-08-26 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Putative Lipoprotein from Bacillus cereus Ordered Locus BC_2438. Northeast Structural Genomics Target BcR103A. To be Published
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2KCT
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![BU of 2kct by Molmil](/molmil-images/mine/2kct) | Solution nmr structure of the ob-fold domain of heme chaperone ccme from desulfovibrio vulgaris. northeast structural genomics target dvr115g. | Descriptor: | Cytochrome c-type biogenesis protein CcmE | Authors: | Aramini, J.M, Rossi, P, Lee, H, Lemak, A, Wang, H, Foote, E.L, Jiang, M, Xiao, R, Nair, R, Swapna, G.V.T, Acton, T.B, Rost, B, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-29 | Release date: | 2009-02-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution nmr structure of the ob-fold domain of heme chaperone
ccme from desulfovibrio vulgaris. northeast structural genomics target dvr115g. To be Published
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2KCL
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![BU of 2kcl by Molmil](/molmil-images/mine/2kcl) | Solution NMR structure of tetratricopeptide repeat domain protein SrU_0103 from Salinibacter ruber, Northeast Structural Genomics Consortium (NESG) Target SrR115C | Descriptor: | Tetratricopeptide repeat domain protein | Authors: | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-22 | Release date: | 2009-01-06 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of tetratricopeptide repeat domain protein SrU_0103 from Salinibacter ruber, Northeast Structural Genomics Consortium (NESG) Target SrR115C To be Published
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2KCY
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![BU of 2kcy by Molmil](/molmil-images/mine/2kcy) | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D | Descriptor: | 30S ribosomal protein S8e | Authors: | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B.C, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-30 | Release date: | 2009-01-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D To be Published
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2KWB
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![BU of 2kwb by Molmil](/molmil-images/mine/2kwb) | Minimal Constraint Solution NMR Structure of Translationally-controlled tumor protein (TCTP) from C.elegans, Northeast Structural Genomics Consortium Target WR73 | Descriptor: | Translationally-controlled tumor protein homolog | Authors: | Aramini, J.M, Rossi, P, Cort, J.R, Cooper, B, Maglaqui, M, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-04-02 | Release date: | 2010-04-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Minimal Constraint Solution NMR Structure of Translationally-controlled tumor protein (TCTP) from C.elegans, Northeast Structural Genomics Consortium Target WR73 To be Published
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2KW6
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![BU of 2kw6 by Molmil](/molmil-images/mine/2kw6) | Solution NMR Structure of Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1; oral cancer suppressor Deleted in oral cancer 1, DOC-1) from H.sapiens, Northeast Structural Genomics Consortium Target Target HR3057H | Descriptor: | Cyclin-dependent kinase 2-associated protein 1 | Authors: | Ertekin, A, Aramini, J.M, Rossi, P, Lee, A.B, Jiang, M, Ciccosanti, C.T, Xiao, R, Swapna, G.V.T, Rost, B, Everett, J.K, Acton, T.B, Prestegard, J.H, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-03-31 | Release date: | 2010-05-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region. J.Biol.Chem., 287, 2012
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2K5D
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![BU of 2k5d by Molmil](/molmil-images/mine/2k5d) | SOLUTION NMR STRUCTURE OF SAG0934 from Streptococcus agalactiae. NORTHEAST STRUCTURAL GENOMICS TARGET SaR32[1-108]. | Descriptor: | uncharacterized protein SAG0934 | Authors: | Aramini, J.M, Rossi, P, Zhao, L, Foote, E.L, Jiang, M, Xiao, R, Sharma, S, Swapna, G.VT, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-06-26 | Release date: | 2008-08-26 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | SOLUTION NMR STRUCTURE OF SAG0934 from Streptococcus agalactiae. NORTHEAST STRUCTURAL GENOMICS TARGET SaR32[1-108]. To be Published
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2JT1
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![BU of 2jt1 by Molmil](/molmil-images/mine/2jt1) | Solution NMR structure of PefI (Plasmid-Encoded Fimbriae Regulatory) protein from Salmonella typhimurium. Northeast Structural Genomics target StR82 | Descriptor: | PefI protein | Authors: | Aramini, J.M, Rossi, P, Wang, H, Nwosu, C, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-07-17 | Release date: | 2007-10-09 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the plasmid-encoded fimbriae regulatory protein PefI from Salmonella enterica serovar Typhimurium. Proteins, 79, 2011
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2JRM
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![BU of 2jrm by Molmil](/molmil-images/mine/2jrm) | Solution NMR structure of ribosome modulation factor VP1593 from Vibrio parahaemolyticus. Northeast Structural Genomics target VpR55 | Descriptor: | Ribosome modulation factor | Authors: | Tang, Y, Rossi, P, Swapna, G, Wang, H, Jiang, M, Cunningham, K, Owens, L, Ma, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-27 | Release date: | 2007-07-17 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Ribosome Modulation Factor VP1593 from Vibrio parahaemolyticus. To be Published
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2JQN
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![BU of 2jqn by Molmil](/molmil-images/mine/2jqn) | Solution NMR structure of CC0527 from Caulobacter crescentus. Northeast Structural Genomics Target CCR55 | Descriptor: | Hypothetical protein | Authors: | Aramini, J.M, Rossi, P, Moseley, H.N.B, Wang, D, Nwosu, C, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-05 | Release date: | 2007-07-03 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of CC0527 from Caulobacter crescentus To be Published
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2KZN
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![BU of 2kzn by Molmil](/molmil-images/mine/2kzn) | Solution NMR Structure of Peptide methionine sulfoxide reductase msrB from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR10 | Descriptor: | Peptide methionine sulfoxide reductase msrB | Authors: | Ertekin, A, Maglaqui, M, Janjua, H, Cooper, B, Ciccosanti, C, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Prestegard, J, Lee, H, Aramini, J.M, Rossi, P, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-18 | Release date: | 2010-07-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples. Proc.Natl.Acad.Sci.USA, 109, 2012
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2LPK
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![BU of 2lpk by Molmil](/molmil-images/mine/2lpk) | Solution NMR of the specialized apo-acyl carrier protein (RPA2022) from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR324 | Descriptor: | Specialized acyl carrier protein | Authors: | Ramelot, T.A, Rossi, P, Yang, Y, Lee, H, Ertekin, A, Wang, H, Ciccosanti, C, Kohan, E, Maglaqui, M, Janjua, H, Nair, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Prestegard, J.H, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-02-14 | Release date: | 2012-02-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations. Biochemistry, 51, 2012
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4J3D
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![BU of 4j3d by Molmil](/molmil-images/mine/4j3d) | Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor | Descriptor: | N~1~-hydroxy-N~5~-(3-hydroxypropyl)-N~2~-[4-(phenylethynyl)benzoyl]-L-glutamamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | Authors: | Lahiri, S. | Deposit date: | 2013-02-05 | Release date: | 2013-04-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the UDP pocket of LpxC through amino acid analogs. Bioorg.Med.Chem.Lett., 23, 2013
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4OKG
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![BU of 4okg by Molmil](/molmil-images/mine/4okg) | |
4OZE
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![BU of 4oze by Molmil](/molmil-images/mine/4oze) | A.aolicus LpxC in complex with native product | Descriptor: | CHLORIDE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, ... | Authors: | Olivier, N.B. | Deposit date: | 2014-02-15 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Mechanistic insight from the crystal structure of A.aolicus LpxC in the presence of product To Be Published
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