4OKG

LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid

Summary for 4OKG

• Entry DOI: 10.2210/pdb4okg/pdb
• Descriptor: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-({6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethynyl)phenyl]pyridine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: hydroxamate, beta-alpha-alpha-beta sandwich, deacetylase, intracellular; cytoplasm, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 67511.29

Authors

Olivier, N.B.,Lahiri, S.D.,Prince, D.B. (deposition date: 2014-01-22, release date: 2014-09-24, Last modification date: 2024-02-28)

• Primary citation: Gao, N.,McLeod, S.M.,Hajec, H.,Lahiri, S.D.,Prince, D.B.,Thresher, J.,Whiteaker, J.,Ross, P.,Olivier, N.B.,Doig, P.; Overexpression of Pseudomonas aeruginosa LpxC in the Presence of an Inhibitor in an acrB Deletion Escherichia coli strain for Structural Studies; Protein Express.Purif., 2014

Experimental method

X-RAY DIFFRACTION (2.06 Å)