4OKG
LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | polymer | 299 | 33146.6 | 2 | UniProt (P47205) Pfam (PF03331) | Pseudomonas aeruginosa | Protein EnvA, UDP-3-O-acyl-GlcNAc deacetylase |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | 6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-({6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethynyl)phenyl]pyridine-3-carboxamide | non-polymer | 543.6 | 2 | Chemie (2SZ) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 299 (UniProt: P47205)
| PDB | External Database | Details |
|---|---|---|
| Ser 40 | Cys 40 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66293.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1218.1 | |
| All* | Total formula weight | 67511.3 |
