7UOY
| NDM1-inhibitor co-structure | Descriptor: | (6P)-4-amino-6-(2H-tetrazol-5-yl)benzene-1,3-disulfonamide, CADMIUM ION, Metallo beta-lactamase, ... | Authors: | Scapin, G, Fischmann, T.O. | Deposit date: | 2022-04-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J.Med.Chem., 65, 2022
|
|
7XMN
| Structure of SARS-CoV-2 ORF8 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltodextrin-binding protein, ... | Authors: | Chen, X, Xu, W. | Deposit date: | 2022-04-26 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation. Microbiol Spectr, 11, 2023
|
|
8JLZ
| ST1936-5HT6R complex | Descriptor: | 2-(5-chloranyl-2-methyl-1~{H}-indol-3-yl)-N,N-dimethyl-ethanamine, 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wen, X, Sun, J. | Deposit date: | 2023-06-04 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6. Biochem.Biophys.Res.Commun., 671, 2023
|
|
1C40
| BAR-HEADED GOOSE HEMOGLOBIN (AQUOMET FORM) | Descriptor: | PROTEIN (HEMOGLOBIN (ALPHA CHAIN)), PROTEIN (HEMOGLOBIN (BETA CHAIN)), PROTOPORPHYRIN IX CONTAINING FE | Authors: | Li, S, Liu, X, Jing, H, Hua, Z, Zhang, R, Lu, G. | Deposit date: | 1999-08-03 | Release date: | 1999-08-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin. Acta Crystallogr.,Sect.D, 57, 2001
|
|
7UYA
| Inhibitor bound VIM1 | Descriptor: | (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION | Authors: | Fischmann, T.O, Scapin, G. | Deposit date: | 2022-05-06 | Release date: | 2023-05-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.01 Å) | Cite: | Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration. J.Med.Chem., 67, 2024
|
|
7UYD
| Inhibitor bound VIM1 | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ... | Authors: | Fischmann, T.O, Scapin, G. | Deposit date: | 2022-05-06 | Release date: | 2023-05-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration. J.Med.Chem., 67, 2024
|
|
7UYB
| Inhibitor bound VIM1 | Descriptor: | (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION | Authors: | Fischmann, T.O, Scapin, G. | Deposit date: | 2022-05-06 | Release date: | 2023-05-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration. J.Med.Chem., 67, 2024
|
|
7UYC
| Inhibitor bound VIM1 | Descriptor: | (2P)-4'-(piperidin-4-yl)-4-[(piperidin-4-yl)methyl]-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, MAGNESIUM ION, ... | Authors: | Fischmann, T.O, Scapin, G. | Deposit date: | 2022-05-06 | Release date: | 2023-05-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration. J.Med.Chem., 67, 2024
|
|
7WQP
| Adeno-associated virus serotype PHP.eB in complex with AAVR | Descriptor: | Capsid protein VP1, Dyslexia-associated protein KIAA0319-like protein | Authors: | Xu, G, Lou, Z. | Deposit date: | 2022-01-25 | Release date: | 2022-06-15 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors. Mol Ther Methods Clin Dev, 26, 2022
|
|
7WQO
| Structure of Adeno-associated virus serotype PHP.eB | Descriptor: | Capsid protein VP1 | Authors: | Xu, G, Lou, Z. | Deposit date: | 2022-01-25 | Release date: | 2022-06-15 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors. Mol Ther Methods Clin Dev, 26, 2022
|
|
7WJX
| Adeno-associated virus serotype 9 in complex with AAVR | Descriptor: | Capsid protein VP1, Dyslexia-associated protein KIAA0319-like protein | Authors: | Xu, G, Lou, Z. | Deposit date: | 2022-01-08 | Release date: | 2022-06-15 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors. Mol Ther Methods Clin Dev, 26, 2022
|
|
7WJW
| Structure of Adeno-associated virus serotype 9 | Descriptor: | Capsid protein VP1 | Authors: | Xu, G, Lou, Z. | Deposit date: | 2022-01-08 | Release date: | 2022-06-15 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors. Mol Ther Methods Clin Dev, 26, 2022
|
|
7ENQ
| Crystal structure of human NAMPT in complex with compound NAT | Descriptor: | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y. | Deposit date: | 2021-04-19 | Release date: | 2022-05-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.204966 Å) | Cite: | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32, 2022
|
|
7EPW
| Crystal structure of monooxygenase Tet(X4) with tigecycline | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, TIGECYCLINE | Authors: | Cheng, Q, Chen, S. | Deposit date: | 2021-04-28 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. Bmc Biol., 19, 2021
|
|
7EPV
| Crystal structure of tigecycline degrading monooxygenase Tet(X4) | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, GLYCEROL | Authors: | Cheng, Q, Chen, S. | Deposit date: | 2021-04-27 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. Bmc Biol., 19, 2021
|
|
7Y42
| |
3FHM
| Crystal structure of the CBS-domain containing protein ATU1752 from Agrobacterium tumefaciens | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ADENOSINE MONOPHOSPHATE, SULFATE ION, ... | Authors: | Singer, A.U, Xu, X, Zhang, R, Cui, H, Kudritsdka, M, Edwards, A.M, Joachimiak, A, Yakunin, A.F, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-12-09 | Release date: | 2009-01-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the CBS-domain containing protein ATU1752 from Agrobacterium tumefaciens To be Published
|
|