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7FSD
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BU of 7fsd by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 44
Descriptor: (1M)-N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)-3',4,4',5-tetrahydroxy[1,1'-biphenyl]-2-sulfonamide, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
Authors:Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
Deposit date:2022-12-18
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS2
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BU of 7fs2 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 13
Descriptor: (1P)-3',4,4',5-tetrahydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}[1,1'-biphenyl]-2-sulfonamide, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
Authors:Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
Deposit date:2022-12-18
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.374 Å)
Cite:Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS8
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BU of 7fs8 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 21
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, 4-[4-(3-aminobenzene-1-sulfonyl)piperazine-1-sulfonyl]benzene-1,2-diol, MAGNESIUM ION, ...
Authors:Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
Deposit date:2022-12-18
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FSC
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BU of 7fsc by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 42
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)benzenesulfonamide, ...
Authors:Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
Deposit date:2022-12-18
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.855 Å)
Cite:Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
4M3S
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BU of 4m3s by Molmil
Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with HEPES
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, SULFATE ION, ...
Authors:Majorek, K.A, Chruszcz, M, Xu, X, Cymborowski, M, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-08-06
Release date:2013-08-21
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments.
Protein Sci., 23, 2014
2J4Z
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BU of 2j4z by Molmil
Structure of Aurora-2 in complex with PHA-680626
Descriptor: 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ARSENIC, SERINE THREONINE-PROTEIN KINASE 6
Authors:Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P.
Deposit date:2006-09-08
Release date:2006-11-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
J. Med. Chem., 49, 2006
8ASG
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BU of 8asg by Molmil
Structure of the SFTSV L protein bound in a resting state [RESTING]
Descriptor: MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ...
Authors:Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M.
Deposit date:2022-08-19
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
3EQZ
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BU of 3eqz by Molmil
Crystal structure of a response regulator from Colwellia psychrerythraea
Descriptor: Response regulator
Authors:Bonanno, J.B, Gilmore, M, Bain, K.T, Iizuka, M, Romero, R, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-10-01
Release date:2008-10-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of a response regulator from Colwellia psychrerythraea
To be Published
3EUX
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BU of 3eux by Molmil
Crystal Structure of Crosslinked Ribonuclease A
Descriptor: Ribonuclease pancreatic
Authors:Dechene, M, Wink, G, Smith, M, Swartz, P, Mattos, C.
Deposit date:2008-10-12
Release date:2009-06-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Multiple solvent crystal structures of ribonuclease A: An assessment of the method
Proteins, 76, 2009
8ASD
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BU of 8asd by Molmil
Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION]
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ...
Authors:Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M.
Deposit date:2022-08-19
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
8ASB
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BU of 8asb by Molmil
Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO]
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), ...
Authors:Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M.
Deposit date:2022-08-18
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
3EV4
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BU of 3ev4 by Molmil
Crystal Structure of Ribonuclease A in 50% Trifluoroethanol
Descriptor: Ribonuclease pancreatic, TRIFLUOROETHANOL
Authors:Dechene, M, Wink, G, Smith, M, Swartz, P, Mattos, C.
Deposit date:2008-10-12
Release date:2009-06-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Multiple solvent crystal structures of ribonuclease A: An assessment of the method
Proteins, 76, 2009
6OZ2
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BU of 6oz2 by Molmil
Crystal structure of the broadly neutralizing antibody N49P6 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N49P6 antibody Fab heavy chain, N49P6 antibody Fab light chain, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2019-05-15
Release date:2020-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer.
Mbio, 2021
8AS7
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BU of 8as7 by Molmil
Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION]
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, ...
Authors:Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M.
Deposit date:2022-08-18
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
8AS6
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BU of 8as6 by Molmil
Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK]
Descriptor: RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*C)-3'), RNA-dependent RNA-polymerase L protein
Authors:Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M.
Deposit date:2022-08-18
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
6SK6
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BU of 6sk6 by Molmil
Cryo-EM structure of rhinovirus-B5
Descriptor: Rhinovirus B5 VP1, Rhinovirus B5 VP2, Rhinovirus B5 VP3, ...
Authors:Wald, J, Goessweiner-Mohr, N, Blaas, D, Pasin, M.
Deposit date:2019-08-14
Release date:2019-09-04
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
6IPW
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BU of 6ipw by Molmil
Crystal structure of CqsB2 from Streptomyces exfoliatus in complex with the product, 1-(2-hydroxypropyl)-2-methyl-carbazole-3,4-dione
Descriptor: 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, CqsB2
Authors:Tomita, T, Kobayashi, M, Nishiyama, M, Kuzuyama, T.
Deposit date:2018-11-05
Release date:2019-10-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.
Angew.Chem.Int.Ed.Engl., 58, 2019
2IO5
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BU of 2io5 by Molmil
Crystal structure of the CIA- histone H3-H4 complex
Descriptor: ASF1A protein, Histone H3.1, Histone H4
Authors:Natsume, R, Akai, Y, Horikoshi, M, Senda, T.
Deposit date:2006-10-10
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4.
Nature, 446, 2007
3EUZ
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BU of 3euz by Molmil
Crystal Structure of Ribonuclease A in 50% Dimethylformamide
Descriptor: DIMETHYLFORMAMIDE, Ribonuclease pancreatic
Authors:Dechene, M, Wink, G, Smith, M, Swartz, P, Mattos, C.
Deposit date:2008-10-12
Release date:2009-06-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Multiple solvent crystal structures of ribonuclease A: An assessment of the method
Proteins, 76, 2009
6SS6
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BU of 6ss6 by Molmil
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187
Descriptor: Arginase-2, mitochondrial, Fab C0020187 heavy chain (IgG1), ...
Authors:Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M.
Deposit date:2019-09-06
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Proc.Natl.Acad.Sci.USA, 117, 2020
6IF6
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BU of 6if6 by Molmil
Structure of the periplasmic domain of SflA
Descriptor: GLYCEROL, PHOSPHATE ION, Protein SflA
Authors:Nishikawa, S, Sakuma, M, Kojima, S, Homma, M, Imada, K.
Deposit date:2018-09-18
Release date:2019-05-01
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the periplasmic domain of SflA involved in spatial regulation of the flagellar biogenesis of Vibrio reveals a TPR/SLR-like fold.
J.Biochem., 166, 2019
6SRX
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BU of 6srx by Molmil
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021158
Descriptor: ACETATE ION, CHLORIDE ION, Fab C0021158 heavy chain (IgG1), ...
Authors:Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M.
Deposit date:2019-09-06
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
8ARH
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BU of 8arh by Molmil
In situ subtomogram average of Vaccinia virus (WR) D13 lattice, on immature virions
Descriptor: Scaffold protein D13
Authors:Calcraft, T, Hernandez-Gonzalez, M, Nans, A, Rosenthal, P.B, Way, M.
Deposit date:2022-08-16
Release date:2023-02-01
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (19.200001 Å)
Cite:A succession of two viral lattices drives vaccinia virus assembly.
Plos Biol., 21, 2023
4V5T
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BU of 4v5t by Molmil
X-ray structure of the Grapevine Fanleaf virus
Descriptor: COAT PROTEIN
Authors:Schellenberger, P, Sauter, C, Lorber, B, Bron, P, Trapani, S, Bergdoll, M, Marmonier, A, Schmitt-Keichinger, C, Lemaire, O, Demangeat, G, Ritzenthaler, C.
Deposit date:2011-02-01
Release date:2014-07-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights Into Viral Determinants of Nematode Mediated Grapevine Fanleaf Virus Transmission.
Plos Pathog., 7, 2011
4V5M
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BU of 4v5m by Molmil
tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE)
Descriptor: 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T.
Deposit date:2010-10-01
Release date:2014-07-09
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010

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