6SS6

Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187

This is a non-PDB format compatible entry.

Summary for 6SS6

• Entry DOI: 10.2210/pdb6ss6/pdb
• Related: 6SRV 6SRX 6SS0 6SS2 6SS4 6SS5 6TUL
• Descriptor: Arginase-2, mitochondrial, Fab C0020187 heavy chain (IgG1), Fab C0020187 light chain (IgG1), ... (5 entities in total)
• Functional Keywords: arginase-2 inhibitor, igg, antigen-binding fragment, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 258980.88

Authors

Burschowsky, D.,Addyman, A.,Fiedler, S.,Groves, M.,Haynes, S.,Seewooruthun, C.,Carr, M. (deposition date: 2019-09-06, release date: 2020-06-10, Last modification date: 2024-01-24)

• Primary citation: Chan, D.T.Y.,Jenkinson, L.,Haynes, S.W.,Austin, M.,Diamandakis, A.,Burschowsky, D.,Seewooruthun, C.,Addyman, A.,Fiedler, S.,Ryman, S.,Whitehouse, J.,Slater, L.H.,Gowans, E.,Shibata, Y.,Barnard, M.,Wilkinson, R.W.,Vaughan, T.J.,Holt, S.V.,Cerundolo, V.,Carr, M.D.,Groves, M.A.T.; Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.; Proc.Natl.Acad.Sci.USA, 117:16949-16960, 2020; PubMed: 32616569; DOI: 10.1073/pnas.1919565117

Experimental method

X-RAY DIFFRACTION (3.25 Å)