Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SS6

Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000050	biological_process	urea cycle
AAA	0001657	biological_process	ureteric bud development
AAA	0002250	biological_process	adaptive immune response
AAA	0002829	biological_process	negative regulation of type 2 immune response
AAA	0004053	molecular_function	arginase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006525	biological_process	arginine metabolic process
AAA	0006809	biological_process	nitric oxide biosynthetic process
AAA	0006941	biological_process	striated muscle contraction
AAA	0016787	molecular_function	hydrolase activity
AAA	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
AAA	0019547	biological_process	arginine catabolic process to ornithine
AAA	0030145	molecular_function	manganese ion binding
AAA	0032651	biological_process	regulation of interleukin-1 beta production
AAA	0032696	biological_process	negative regulation of interleukin-13 production
AAA	0032700	biological_process	negative regulation of interleukin-17 production
AAA	0032720	biological_process	negative regulation of tumor necrosis factor production
AAA	0045087	biological_process	innate immune response
AAA	0046872	molecular_function	metal ion binding
AAA	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
AAA	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
AAA	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
AAA	1900425	biological_process	negative regulation of defense response to bacterium
AAA	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
AAA	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
AAA	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
AAA	2000774	biological_process	positive regulation of cellular senescence
BBB	0000050	biological_process	urea cycle
BBB	0001657	biological_process	ureteric bud development
BBB	0002250	biological_process	adaptive immune response
BBB	0002829	biological_process	negative regulation of type 2 immune response
BBB	0004053	molecular_function	arginase activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0006525	biological_process	arginine metabolic process
BBB	0006809	biological_process	nitric oxide biosynthetic process
BBB	0006941	biological_process	striated muscle contraction
BBB	0016787	molecular_function	hydrolase activity
BBB	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
BBB	0019547	biological_process	arginine catabolic process to ornithine
BBB	0030145	molecular_function	manganese ion binding
BBB	0032651	biological_process	regulation of interleukin-1 beta production
BBB	0032696	biological_process	negative regulation of interleukin-13 production
BBB	0032700	biological_process	negative regulation of interleukin-17 production
BBB	0032720	biological_process	negative regulation of tumor necrosis factor production
BBB	0045087	biological_process	innate immune response
BBB	0046872	molecular_function	metal ion binding
BBB	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
BBB	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
BBB	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
BBB	1900425	biological_process	negative regulation of defense response to bacterium
BBB	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
BBB	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
BBB	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
BBB	2000774	biological_process	positive regulation of cellular senescence
CCC	0000050	biological_process	urea cycle
CCC	0001657	biological_process	ureteric bud development
CCC	0002250	biological_process	adaptive immune response
CCC	0002829	biological_process	negative regulation of type 2 immune response
CCC	0004053	molecular_function	arginase activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006525	biological_process	arginine metabolic process
CCC	0006809	biological_process	nitric oxide biosynthetic process
CCC	0006941	biological_process	striated muscle contraction
CCC	0016787	molecular_function	hydrolase activity
CCC	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
CCC	0019547	biological_process	arginine catabolic process to ornithine
CCC	0030145	molecular_function	manganese ion binding
CCC	0032651	biological_process	regulation of interleukin-1 beta production
CCC	0032696	biological_process	negative regulation of interleukin-13 production
CCC	0032700	biological_process	negative regulation of interleukin-17 production
CCC	0032720	biological_process	negative regulation of tumor necrosis factor production
CCC	0045087	biological_process	innate immune response
CCC	0046872	molecular_function	metal ion binding
CCC	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
CCC	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
CCC	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
CCC	1900425	biological_process	negative regulation of defense response to bacterium
CCC	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
CCC	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
CCC	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
CCC	2000774	biological_process	positive regulation of cellular senescence

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
LLL	TYR192-HIS198
HHH	TYR194-HIS200

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDIDafdPtlaPAtgtpvvgG

Chain	Residue	Details
AAA	SER249-GLY270

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	BINDING: BINDING => ECO:0000269\|PubMed:12859189, ECO:0007744\|PDB:1PQ3, ECO:0007744\|PDB:4HZE, ECO:0007744\|PDB:4I06, ECO:0007744\|PDB:4IE2, ECO:0007744\|PDB:4IE3, ECO:0007744\|PDB:4IXU, ECO:0007744\|PDB:4IXV

Chain	Residue	Details
AAA	HIS120
BBB	HIS120
BBB	ASP143
BBB	HIS145
BBB	ASP147
BBB	SER156
BBB	ASP202
BBB	ASP251
BBB	ASP253
BBB	GLU296
CCC	HIS120
AAA	ASP143
CCC	ASP143
CCC	HIS145
CCC	ASP147
CCC	SER156
CCC	ASP202
CCC	ASP251
CCC	ASP253
CCC	GLU296
AAA	HIS145
AAA	ASP147
AAA	SER156
AAA	ASP202
AAA	ASP251
AAA	ASP253
AAA	GLU296

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P53608

Chain	Residue	Details
AAA	THR265
BBB	THR265
CCC	THR265

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)