6SS6

Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000050	biological_process	urea cycle
AAA	0001657	biological_process	ureteric bud development
AAA	0002250	biological_process	adaptive immune response
AAA	0002376	biological_process	immune system process
AAA	0002829	biological_process	negative regulation of type 2 immune response
AAA	0004053	molecular_function	arginase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006525	biological_process	arginine metabolic process
AAA	0006809	biological_process	nitric oxide biosynthetic process
AAA	0016787	molecular_function	hydrolase activity
AAA	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
AAA	0030145	molecular_function	manganese ion binding
AAA	0032651	biological_process	regulation of interleukin-1 beta production
AAA	0032696	biological_process	negative regulation of interleukin-13 production
AAA	0032700	biological_process	negative regulation of interleukin-17 production
AAA	0032720	biological_process	negative regulation of tumor necrosis factor production
AAA	0045087	biological_process	innate immune response
AAA	0046872	molecular_function	metal ion binding
AAA	0051241	biological_process	negative regulation of multicellular organismal process
AAA	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
AAA	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
AAA	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
AAA	1900425	biological_process	negative regulation of defense response to bacterium
AAA	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
AAA	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
AAA	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
AAA	2000774	biological_process	positive regulation of cellular senescence
BBB	0000050	biological_process	urea cycle
BBB	0001657	biological_process	ureteric bud development
BBB	0002250	biological_process	adaptive immune response
BBB	0002376	biological_process	immune system process
BBB	0002829	biological_process	negative regulation of type 2 immune response
BBB	0004053	molecular_function	arginase activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0006525	biological_process	arginine metabolic process
BBB	0006809	biological_process	nitric oxide biosynthetic process
BBB	0016787	molecular_function	hydrolase activity
BBB	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
BBB	0030145	molecular_function	manganese ion binding
BBB	0032651	biological_process	regulation of interleukin-1 beta production
BBB	0032696	biological_process	negative regulation of interleukin-13 production
BBB	0032700	biological_process	negative regulation of interleukin-17 production
BBB	0032720	biological_process	negative regulation of tumor necrosis factor production
BBB	0045087	biological_process	innate immune response
BBB	0046872	molecular_function	metal ion binding
BBB	0051241	biological_process	negative regulation of multicellular organismal process
BBB	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
BBB	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
BBB	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
BBB	1900425	biological_process	negative regulation of defense response to bacterium
BBB	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
BBB	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
BBB	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
BBB	2000774	biological_process	positive regulation of cellular senescence
CCC	0000050	biological_process	urea cycle
CCC	0001657	biological_process	ureteric bud development
CCC	0002250	biological_process	adaptive immune response
CCC	0002376	biological_process	immune system process
CCC	0002829	biological_process	negative regulation of type 2 immune response
CCC	0004053	molecular_function	arginase activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006525	biological_process	arginine metabolic process
CCC	0006809	biological_process	nitric oxide biosynthetic process
CCC	0016787	molecular_function	hydrolase activity
CCC	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
CCC	0030145	molecular_function	manganese ion binding
CCC	0032651	biological_process	regulation of interleukin-1 beta production
CCC	0032696	biological_process	negative regulation of interleukin-13 production
CCC	0032700	biological_process	negative regulation of interleukin-17 production
CCC	0032720	biological_process	negative regulation of tumor necrosis factor production
CCC	0045087	biological_process	innate immune response
CCC	0046872	molecular_function	metal ion binding
CCC	0051241	biological_process	negative regulation of multicellular organismal process
CCC	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
CCC	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
CCC	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
CCC	1900425	biological_process	negative regulation of defense response to bacterium
CCC	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
CCC	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
CCC	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
CCC	2000774	biological_process	positive regulation of cellular senescence

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
LLL	TYR192-HIS198
HHH	TYR194-HIS200

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site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDIDafdPtlaPAtgtpvvgG

Chain	Residue	Details
AAA	SER249-GLY270

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12859189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PQ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IXV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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