6SS6

Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA, BBB, CCC	Arginase-2, mitochondrial	polymer	346	37808.6	3	UniProt (P78540) Pfam (PF00491) In PDB	Homo sapiens (Human)	Arginase II,Kidney-type arginase,Non-hepatic arginase,Type II arginase
2	HHH, III, JJJ	Fab C0020187 heavy chain (IgG1)	polymer	233	24479.5	3		Homo sapiens (Human)
3	LLL, MMM, NNN	Fab C0020187 light chain (IgG1)	polymer	220	23064.5	3		Homo sapiens (Human)
4	AAA, BBB, CCC	MANGANESE (II) ION	non-polymer		54.9	6	Chemie (MN)
5	CCC, HHH, III, JJJ, AAA...	SULFATE ION	non-polymer		96.1	27	Chemie (SO4)

Sequence modifications

AAA, BBB, CCC: 23 - 354 (UniProt: P78540)

PDB	External Database	Details
Met 22	-	initiating methionine
Gly 355	-	expression tag
Gly 356	-	expression tag
Gly 357	-	expression tag
His 358	-	expression tag
His 359	-	expression tag
His 360	-	expression tag
His 361	-	expression tag
His 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	256057.5
Non-Polymers*	Number of molecules	33
	Total formula weight	2923.3
All*	Total formula weight	258980.9

*Water molecules are not included.