6IPW

Crystal structure of CqsB2 from Streptomyces exfoliatus in complex with the product, 1-(2-hydroxypropyl)-2-methyl-carbazole-3,4-dione

Summary for 6IPW

Entry DOI	10.2210/pdb6ipw/pdb
Descriptor	CqsB2, 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione (3 entities in total)
Functional Keywords	carbazole biosynthesis, polyketide aromatase/cyclase, biosynthetic protein
Biological source	Streptomyces exfoliatus
Total number of polymer chains	4
Total formula weight	111657.60
Authors	Tomita, T.,Kobayashi, M.,Nishiyama, M.,Kuzuyama, T. (deposition date: 2018-11-05, release date: 2019-10-16, Last modification date: 2023-11-22)
Primary citation	Kobayashi, M.,Tomita, T.,Shin-Ya, K.,Nishiyama, M.,Kuzuyama, T. An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces. Angew.Chem.Int.Ed.Engl., 58:13349-13353, 2019 Cited by PubMed: 31350791 DOI: 10.1002/anie.201906864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation