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2I1J
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BU of 2i1j by Molmil
Moesin from Spodoptera frugiperda at 2.1 angstroms resolution
Descriptor: CHLORIDE ION, GLYCEROL, Moesin, ...
Authors:Li, Q, Nance, M.R, Tesmer, J.J.G.
Deposit date:2006-08-14
Release date:2006-12-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain.
J.Mol.Biol., 365, 2007
2I1K
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BU of 2i1k by Molmil
Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution
Descriptor: CHLORIDE ION, GLYCEROL, Moesin, ...
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2006-08-14
Release date:2006-12-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain.
J.Mol.Biol., 365, 2007
4GNK
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BU of 4gnk by Molmil
Crystal structure of Galphaq in complex with full-length human PLCbeta3
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2012-08-17
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain.
Nat.Struct.Mol.Biol., 20, 2013
3QR1
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BU of 3qr1 by Molmil
Crystal Structure of L. pealei PLC21
Descriptor: CALCIUM ION, PHOSPHOLIPASE C-BETA (PLC-BETA)
Authors:Lyon, A.M, Suddala, K.C, Northup, J.K, Tesmer, J.J.G.
Deposit date:2011-02-16
Release date:2011-08-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An autoinhibitory helix in the C-terminal region of phospholipase C-beta mediates Galphaq activation.
Nat.Struct.Mol.Biol., 18, 2011
3QR0
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BU of 3qr0 by Molmil
Crystal Structure of S. officinalis PLC21
Descriptor: CALCIUM ION, GLYCEROL, phospholipase C-beta (PLC-beta)
Authors:Lyon, A.M, Northup, J.K, Tesmer, J.J.G.
Deposit date:2011-02-16
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:An autoinhibitory helix in the C-terminal region of phospholipase C-beta mediates Galphaq activation.
Nat.Struct.Mol.Biol., 18, 2011
4BEZ
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BU of 4bez by Molmil
Night blindness causing G90D rhodopsin in the active conformation
Descriptor: ACETATE ION, PALMITIC ACID, RHODOPSIN, ...
Authors:Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J.
Deposit date:2013-03-12
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin.
Embo Rep., 14, 2013
4BEY
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BU of 4bey by Molmil
Night blindness causing G90D rhodopsin in complex with GaCT2 peptide
Descriptor: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
Authors:Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J.
Deposit date:2013-03-12
Release date:2013-05-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin.
Embo Rep., 14, 2013
4PNK
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BU of 4pnk by Molmil
G protein-coupled receptor kinase 2 in complex with GSK180736A
Descriptor: (4S)-4-(4-fluorophenyl)-N-(2H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Homan, K.T, Larimore, K.M, Elkins, J, Knapp, S, Tesmer, J.J.G.
Deposit date:2014-05-23
Release date:2014-10-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.
Acs Chem.Biol., 10, 2015
3V5W
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BU of 3v5w by Molmil
Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine
Descriptor: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Thal, D.M, Tesmer, J.J.G.
Deposit date:2011-12-17
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
Acs Chem.Biol., 7, 2012
4QJ4
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BU of 4qj4 by Molmil
Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex with Galphaq
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2014-06-03
Release date:2014-10-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
4PNI
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BU of 4pni by Molmil
Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A
Descriptor: 3-[(2-{[1-(N,N-dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide, CHLORIDE ION, Rhodopsin kinase
Authors:Homan, K.T, Tesmer, J.J.G.
Deposit date:2014-05-23
Release date:2014-10-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.
Acs Chem.Biol., 10, 2015
4QJ3
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BU of 4qj3 by Molmil
Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2014-06-03
Release date:2014-10-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
4QJ5
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BU of 4qj5 by Molmil
Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2014-06-03
Release date:2014-10-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
3C50
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BU of 3c50 by Molmil
Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C51
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BU of 3c51 by Molmil
Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BROMIDE ION, MAGNESIUM ION, ...
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C4X
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BU of 3c4x by Molmil
Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C4Z
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BU of 3c4z by Molmil
Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
5HE1
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BU of 5he1 by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG224062
Descriptor: (4~{S})-4-[4-fluoranyl-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
5FI1
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BU of 5fi1 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
Descriptor: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5HE0
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BU of 5he0 by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and CCG215022
Descriptor: (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
5HE3
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BU of 5he3 by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and CCG224411
Descriptor: (4~{S})-4-[3-[2-(2,6-dimethylphenyl)ethylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
5HE2
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BU of 5he2 by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and CCG224406
Descriptor: (4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
3C4W
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BU of 3c4w by Molmil
Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C4Y
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BU of 3c4y by Molmil
Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A
Descriptor: Rhodopsin kinase
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (7.509 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
1ZCB
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BU of 1zcb by Molmil
Crystal structure of G alpha 13 in complex with GDP
Descriptor: G alpha i/13, GUANOSINE-5'-DIPHOSPHATE
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006

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