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6YK5
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BU of 6yk5 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A
Descriptor: (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
6YK6
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BU of 6yk6 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A
Descriptor: (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.469 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
6YK4
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BU of 6yk4 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-6-methyl-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.00A
Descriptor: (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.999 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
8R36
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BU of 8r36 by Molmil
Crystal structure of the Gluk1 ligand-binding domain in complex with kainate and BPAM538 at 1.90 A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ...
Authors:Bay, Y, Frantsen, S.M, Frydenvang, K, Kastrup, J.S.
Deposit date:2023-11-08
Release date:2024-08-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538.
J.Struct.Biol., 216, 2024
8R32
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BU of 8r32 by Molmil
Crystal structure of the GluK2 ligand-binding domain in complex with L-glutamate and BPAM344 at 1.60 A resolution
Descriptor: 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, GLUTAMIC ACID, ...
Authors:Bay, Y, Jeppesen, M.E, Frydenvang, K, Kastrup, J.S.
Deposit date:2023-11-08
Release date:2024-09-18
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.
Febs Lett., 598, 2024
4MH5
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BU of 4mh5 by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate
Descriptor: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ...
Authors:Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-08-29
Release date:2013-10-16
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.
J.Struct.Biol., 176, 2011
4IGT
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BU of 4igt by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist ZA302 at 1.24A resolution
Descriptor: (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, GLYCEROL, Glutamate receptor 2, ...
Authors:Larsen, A.P, Venskutonyte, R, Gajhede, M, Kastrup, J.S, Frydenvang, K.
Deposit date:2012-12-18
Release date:2013-03-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.
J.Med.Chem., 56, 2013
4IY6
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BU of 4iy6 by Molmil
Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution
Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ...
Authors:Krintel, C, Frydenvang, K, Harpsoe, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-01-28
Release date:2013-10-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Acta Crystallogr.,Sect.D, 69, 2013
4ISU
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BU of 4isu by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.
Descriptor: (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid, CHLORIDE ION, Glutamate receptor 2, ...
Authors:Juknaite, L, Frydenvang, K, Kastrup, J.S.
Deposit date:2013-01-17
Release date:2013-03-20
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.
J.Med.Chem., 56, 2013
4O3A
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BU of 4o3a by Molmil
Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution
Descriptor: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ...
Authors:Krintel, C, Frydenvang, F, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Febs J., 281, 2014
4O3B
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BU of 4o3b by Molmil
Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution
Descriptor: ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Krintel, C, de Rabassa, A.C, Frydenvang, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Febs J., 281, 2014
4KFQ
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BU of 4kfq by Molmil
Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one
Descriptor: 1-sulfanyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one, GLYCEROL, Glutamate receptor ionotropic, ...
Authors:Steffensen, T.B, Tabrizi, F.M, Gajhede, M, Kastrup, J.S.
Deposit date:2013-04-27
Release date:2013-10-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.
J.Biol.Chem., 288, 2013
4O3C
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BU of 4o3c by Molmil
Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution
Descriptor: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ...
Authors:Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S.
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Febs J., 281, 2014
4IY5
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BU of 4iy5 by Molmil
Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution
Descriptor: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ...
Authors:Krintel, C, Frydenvang, K, Harpsoe, K, Gajhede, M, Kastrup, J.S.
Deposit date:2013-01-28
Release date:2013-10-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Acta Crystallogr.,Sect.D, 69, 2013
5NF5
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BU of 5nf5 by Molmil
Structure of GluK1 ligand-binding domain (S1S2) in complex with CIP-AS at 2.85 A resolution
Descriptor: (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Venskutonyte, R, Thorsen, T.S, Kastrup, J.S.
Deposit date:2017-03-13
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
5O4F
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BU of 5o4f by Molmil
Structure of GluK3 ligand-binding domain (S1S2) in complex with the agonist LM-12b at 2.10 A resolution
Descriptor: (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Moellerud, S, Frydenvang, K, Kastrup, J.S.
Deposit date:2017-05-29
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
5M2V
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BU of 5m2v by Molmil
Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution
Descriptor: (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Frydenvang, K, Kastrup, J.S, Kristensen, C.M.
Deposit date:2016-10-13
Release date:2017-01-11
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid.
J. Med. Chem., 60, 2017
5NIH
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BU of 5nih by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution.
Descriptor: (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Laulumaa, S, Frydenvang, K.A, Kastrup, J.S.
Deposit date:2017-03-24
Release date:2017-07-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
5NEB
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BU of 5neb by Molmil
Structure of GluK1 ligand-binding domain (S1S2) in complex with LM-12b at 2.05 A resolution
Descriptor: (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Moellerud, S, Frydenvang, K, Laulumaa, S, Kastrup, J.S.
Deposit date:2017-03-10
Release date:2017-07-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
5NG9
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BU of 5ng9 by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution.
Descriptor: (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid, (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, CITRATE ANION, ...
Authors:Laulumaa, S, Frydenvang, K.A, Winther, S, Kastrup, J.S.
Deposit date:2017-03-17
Release date:2017-07-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
5NF6
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BU of 5nf6 by Molmil
Structure of GluK3 ligand-binding domain (S1S2) in complex with CIP-AS at 2.55 A resolution
Descriptor: (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ...
Authors:Frydenvang, K, Venskutonyte, R, Thorsen, T.S, Kastrup, J.S.
Deposit date:2017-03-13
Release date:2017-07-26
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
ACS Chem Neurosci, 8, 2017
2ANJ
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BU of 2anj by Molmil
Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2
Authors:Holm, M.M, Naur, P, Vestergaard, B, Geballe, M.T, Gajhede, M, Kastrup, J.S, Traynelis, S.F, Egebjerg, J.
Deposit date:2005-08-11
Release date:2005-08-30
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2: a mutagenic, kinetic, and crystallographic study
J.Biol.Chem., 280, 2005
4E0W
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BU of 4e0w by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2012-03-05
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3501 Å)
Cite:Kainate induces various domain closures in AMPA and kainate receptors.
Neurochem Int, 61, 2012
5CC2
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BU of 5cc2 by Molmil
STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA
Descriptor: 7-Chlorokynurenic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Naur, P, Gajhede, M, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
Mol.Pharmacol., 89, 2016
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