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2F6X
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BU of 2f6x by Molmil
Crystal Structure of (S)-3-O-Geranylgeranylglyceryl Phosphate Synthase complexed with sn-G1P and MPD
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (S)-3-O-Geranylgeranylglyceryl Phosphate Synthase, SN-GLYCEROL-1-PHOSPHATE
Authors:Payandeh, J.M.
Deposit date:2005-11-29
Release date:2006-01-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme
J.Biol.Chem., 281, 2006
8TLM
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BU of 8tlm by Molmil
Structure of a class A GPCR/Fab complex
Descriptor: C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ...
Authors:Sun, D, Johnson, M, Masureel, M.
Deposit date:2023-07-27
Release date:2023-12-20
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
4EED
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BU of 4eed by Molmil
CorA coiled-coil mutant under Mg2+ presence
Descriptor: MAGNESIUM ION, Magnesium transport protein CorA
Authors:Pfoh, R, Pai, E.F.
Deposit date:2012-03-28
Release date:2012-11-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EEB
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BU of 4eeb by Molmil
CorA coiled-coil mutant under Mg2+ absence
Descriptor: CESIUM ION, Magnesium transport protein CorA, SODIUM ION
Authors:Pfoh, R, Pai, E.F.
Deposit date:2012-03-28
Release date:2012-11-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.
Proc.Natl.Acad.Sci.USA, 109, 2012
6WJ5
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BU of 6wj5 by Molmil
Structure of human TRPA1 in complex with inhibitor GDC-0334
Descriptor: (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide, Transient receptor potential cation channel subfamily A member 1
Authors:Rohou, A, Rouge, L, Arthur, C.P, Volgraf, M, Chen, H.
Deposit date:2020-04-11
Release date:2021-02-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
J.Exp.Med., 218, 2021
6X2J
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BU of 6x2j by Molmil
Structure of human TRPA1 in complex with agonist GNE551
Descriptor: 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, Transient receptor potential cation channel subfamily A member 1
Authors:Rohou, A, Rouge, L, Chen, H.
Deposit date:2020-05-20
Release date:2020-11-18
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Neuron, 109, 2021
8U1U
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BU of 8u1u by Molmil
Structure of a class A GPCR/agonist complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, D, Johnson, M, Masureel, M.
Deposit date:2023-09-02
Release date:2023-12-20
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
8U31
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BU of 8u31 by Molmil
Crystal structure of PD-1 in complex with a Fab
Descriptor: Fab heavy chain, Fab light chain, GLYCEROL, ...
Authors:Sun, D, Masureel, M.
Deposit date:2023-09-07
Release date:2024-06-19
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
Mabs, 16, 2024
8U32
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BU of 8u32 by Molmil
Crystal structure of PD-1 in complex with a Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ...
Authors:Sun, D, Masureel, M.
Deposit date:2023-09-07
Release date:2024-06-19
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
Mabs, 16, 2024
8W0S
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BU of 8w0s by Molmil
Human EBP complexed with compound 3a
Descriptor: 1-methyl-8-[(oxan-4-yl)methyl]-3-[4-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Authors:Sun, D, Masureel, M.
Deposit date:2024-02-14
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
J.Med.Chem., 67, 2024
8W0R
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BU of 8w0r by Molmil
Human EBP complexed with compound 1
Descriptor: 1-methyl-1'-[(oxan-4-yl)methyl]-5-(trifluoromethyl)spiro[indole-2,4'-piperidin]-3(1H)-one, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Authors:Sun, D, Masureel, M.
Deposit date:2024-02-14
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
J.Med.Chem., 67, 2024
6VJA
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BU of 6vja by Molmil
Structure of CD20 in complex with rituximab Fab
Descriptor: B-lymphocyte antigen CD20, CHOLESTEROL HEMISUCCINATE, Rituximab Fab heavy chain, ...
Authors:Rohou, A, Croll, T.I.
Deposit date:2020-01-15
Release date:2020-02-26
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.
Science, 367, 2020
7T99
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BU of 7t99 by Molmil
Crystal structure of engineered CYS-CYS fab dimer CL-205 (LC25)
Descriptor: FAB Heavy Chain, FAB Light Chain, PHOSPHATE ION
Authors:Harris, S.F, Boenig, G.D.L.
Deposit date:2021-12-18
Release date:2022-10-12
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Antibody interfaces revealed through structural mining.
Comput Struct Biotechnol J, 20, 2022
7T98
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BU of 7t98 by Molmil
Crystal structure of engineered CYS-CYS fab dimer VL-108 (LC33)
Descriptor: FAB Heavy Chain, FAB Light Chain
Authors:Harris, S.F, Boenig, G.D.L.
Deposit date:2021-12-18
Release date:2022-10-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Antibody interfaces revealed through structural mining.
Comput Struct Biotechnol J, 20, 2022
7T97
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BU of 7t97 by Molmil
Crystal structure of engineered CYS-CYS fab dimer CH1-207 (HC4)
Descriptor: FAB Heavy chain, FAB Light Chain
Authors:Harris, S.F, Boenig, G.D.L.
Deposit date:2021-12-18
Release date:2022-10-12
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.144 Å)
Cite:Antibody interfaces revealed through structural mining.
Comput Struct Biotechnol J, 20, 2022
6C1P
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BU of 6c1p by Molmil
HypoPP mutant
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHAPSO, Ion transport protein, ...
Authors:Catterall, W.A, Zheng, N, Jiang, D, Gamal El-Din, T.M.
Deposit date:2018-01-05
Release date:2018-05-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for gating pore current in periodic paralysis.
Nature, 557, 2018
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