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Structure of an open and closed conformation of Human Importin Beta bound to the Snurportin1 IBB-domain trapped in the same crystallographic asymmetric unit
Descriptor:	Importin subunit beta-1, Snurportin-1
Authors:	Bhardwaj, A, Cingolani, G.
Deposit date:	2010-02-24
Release date:	2010-06-02
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta. Biochemistry, 49, 2010

4DKW

Structure of P22 Large terminase nuclease domain
Descriptor:	Large terminase protein, MAGNESIUM ION, SULFATE ION
Authors:	Roy, A, Cingolani, G.
Deposit date:	2012-02-04
Release date:	2012-06-27
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Structure of p22 headful packaging nuclease. J.Biol.Chem., 287, 2012

4EI2

Crystal Structures of MthK RCK gating ring bound to Barium
Descriptor:	BARIUM ION, Calcium-gated potassium channel mthK
Authors:	Smith, F.J, Cingolani, G, Rothberg, B.S.
Deposit date:	2012-04-04
Release date:	2012-12-19
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.108 Å)
Cite:	Crystal Structure of a Ba(2+)-Bound Gating Ring Reveals Elementary Steps in RCK Domain Activation. Structure, 20, 2012

7JXT

Ovine COX-1 in complex with the subtype-selective derivative 2a
Descriptor:	2-[4,5-bis(2-chlorophenyl)-1H-imidazol-2-yl]-6-(prop-2-en-1-yl)phenyl methoxyacetate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:	Ko, Y, Iaselli, M, Miciaccia, M, Friedrich, L, Schneider, G, Scilimati, A, Cingolani, G.
Deposit date:	2020-08-27
Release date:	2021-09-01
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (3.35 Å)
Cite:	Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design. Adv Sci, 8, 2021

9BGN

Pseudomonas phage DEV 5-fold vertex (major coat protein)
Descriptor:	gp77 major coat protein
Authors:	Iglesias, S.M, Hou, C.F.D, Li, F, Cingolani, G.
Deposit date:	2024-04-19
Release date:	2024-09-04
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. Nat Commun, 15, 2024

9BGM

Pseudomonas phage DEV neck and tail (portal, head-to-tail and tail tube proteins)
Descriptor:	gp75 tail tube, gp80 portal protein, gp83 head-to-tail
Authors:	Iglesias, S.M, Hou, C.-F.D, Li, F, Cingolani, G.
Deposit date:	2024-04-19
Release date:	2024-09-04
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. Nat Commun, 15, 2024

9BGO

Pseudomonas phage DEV gp72 ejection protein (pre-ejection conformation)
Descriptor:	gp72
Authors:	Iglesias, S.M, Hou, C.F.D, Li, F, Cingolani, G.
Deposit date:	2024-04-19
Release date:	2024-09-04
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. Nat Commun, 15, 2024

3RWN

Atomic structure of bacteriophage sf6 tail needle knob
Descriptor:	GLUTAMIC ACID, Gene 9 protein, PHOSPHATE ION
Authors:	Bhardwaj, A, Cingolani, G.
Deposit date:	2011-05-09
Release date:	2011-06-08
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1 Å)
Cite:	Atomic structure of bacteriophage Sf6 tail needle knob. J.Biol.Chem., 286, 2011

3TJ3

Structure of importin a5 bound to the N-terminus of Nup50
Descriptor:	Importin subunit alpha-1, Nuclear pore complex protein Nup50
Authors:	Pumroy, R, Nardozzi, J.D, Hart, D.J, Root, M.J, Cingolani, G.
Deposit date:	2011-08-23
Release date:	2011-11-30
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.702 Å)
Cite:	Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin alpha 5. J.Biol.Chem., 287, 2012

2Q5D

Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form
Descriptor:	Importin beta-1 subunit, Snurportin-1
Authors:	Mitrousis, G, Cingolani, G.
Deposit date:	2007-05-31
Release date:	2008-01-22
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}. J.Biol.Chem., 283, 2008

2P8Q

Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain
Descriptor:	Importin beta-1 subunit, Snurportin-1
Authors:	Mitrousis, G, Cingolani, G.
Deposit date:	2007-03-22
Release date:	2008-01-22
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}. J.Biol.Chem., 283, 2008

4HRF

Atomic structure of DUSP26
Descriptor:	Dual specificity protein phosphatase 26
Authors:	Lokareddy, R.K, Bhardwaj, A, Cingolani, G.
Deposit date:	2012-10-27
Release date:	2013-01-23
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.68 Å)
Cite:	Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. Biochemistry, 52, 2013

5JJ1

Structure of the Immature Procapsid Conformation of P22 Portal Protein
Descriptor:	Portal protein
Authors:	Lokareddy, R.K, Cingolani, G.
Deposit date:	2016-04-22
Release date:	2017-02-08
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Nat Commun, 8, 2017

5JJ3

Refined Structure of the Mature Virion Conformation of P22 Portal Protein
Descriptor:	Portal protein
Authors:	Lokareddy, R.K, Sankhala, R.S, Cingolani, G.
Deposit date:	2016-04-22
Release date:	2017-02-08
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (7 Å)
Cite:	Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Nat Commun, 8, 2017

3P9A

An atomic view of the nonameric small terminase subunit of Bacteriophage P22
Descriptor:	DNA-packaging protein gp3
Authors:	Bhardwaj, A, Roy, A, Cingolani, G.
Deposit date:	2010-10-17
Release date:	2012-05-09
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.755 Å)
Cite:	Small terminase couples viral DNA binding to genome-packaging ATPase activity. Structure, 20, 2012

3Q5U

A minimal NLS from human scramblase 4 complexed with importin alpha
Descriptor:	Importin subunit alpha-2, Phospholipid scramblase 4
Authors:	Bhardwaj, A, Cingolani, G.
Deposit date:	2010-12-29
Release date:	2011-06-29
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin {alpha}1. J.Biol.Chem., 286, 2011

4KEE

Crystal Structure of Cofilin Mutant (cof1-158p)
Descriptor:	Cofilin
Authors:	Kish-Trier, E, Haarer, B, Cingolani, G, Amberg, D.C.
Deposit date:	2013-04-25
Release date:	2013-05-15
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.448 Å)
Cite:	Crystal Structure of Cofilin Mutant (cof1-158p) To be Published

4K6B

Atomic structure of bacteriophage HS1 tail needle knob
Descriptor:	GLUTAMIC ACID, HS1 knob domain, PHOSPHATE ION
Authors:	Bhardwaj, A, Cingolani, G.
Deposit date:	2013-04-15
Release date:	2013-08-28
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.101 Å)
Cite:	The tip of the tail needle affects the rate of DNA delivery by bacteriophage p22. Plos One, 8, 2013

5BU5

HK620 Tail Needle crystallized at pH 9 (crystal form I)
Descriptor:	CALCIUM ION, CHLORIDE ION, DNA stabilization protein
Authors:	Bhardwaj, A, Cingolani, G.
Deposit date:	2015-06-03
Release date:	2015-06-24
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.952 Å)
Cite:	Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions. J.Biol.Chem., 291, 2016

4R30

Structure of human laforin dual specificity phosphatase domain
Descriptor:	BETA-MERCAPTOETHANOL, Laforin, SULFATE ION
Authors:	Sankhala, R.S, Koksal, A.C, Cingolani, G.
Deposit date:	2014-08-13
Release date:	2014-12-31
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Dimeric quaternary structure of human laforin. J.Biol.Chem., 290, 2015

5BVZ

HK620 Tail Needle crystallized at pH 9 (Crystal form II)
Descriptor:	CALCIUM ION, CHLORIDE ION, DNA stabilization protein
Authors:	Bhardwaj, A, Cingolani, G.
Deposit date:	2015-06-05
Release date:	2015-06-24
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions. J.Biol.Chem., 291, 2016

5D5K

Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB
Descriptor:	Importin subunit alpha-1, Poly [ADP-ribose] polymerase 2
Authors:	Riccio, A.A, Cingolani, G, Pascal, J.M.
Deposit date:	2015-08-10
Release date:	2016-06-22
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res., 44, 2016

5BU8

HK620 Tail Needle crystallized at pH 7.5 and derivatized with Xenon
Descriptor:	CALCIUM ION, DNA stabilization protein, XENON
Authors:	Sankhala, R.S, Cingolani, G.
Deposit date:	2015-06-03
Release date:	2015-11-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.202 Å)
Cite:	Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions. J.Biol.Chem., 291, 2016

4UAF

Importin alpha 1 delta IBB in complex with Influenza PB2 nuclear localization domain
Descriptor:	Importin subunit alpha-1, PHOSPHATE ION, Polymerase basic protein 2
Authors:	Pumroy, R.A, Cingolani, G.
Deposit date:	2014-08-08
Release date:	2015-02-04
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.698 Å)
Cite:	Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin alpha Isoforms 3 and 7. Structure, 23, 2015

7LF4

Structure of importin a3 bound to the p50- and p65-NLSs
Descriptor:	Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65
Authors:	Florio, T.J, Lokareddy, R.K, Cingolani, G.
Deposit date:	2021-01-15
Release date:	2022-01-19
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022

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