4R30

Structure of human laforin dual specificity phosphatase domain

Summary for 4R30

Entry DOI	10.2210/pdb4r30/pdb
Descriptor	Laforin, SULFATE ION, BETA-MERCAPTOETHANOL, ... (4 entities in total)
Functional Keywords	dual specificity phosphatase, glucan phosphatase, malin, glycogen, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm . Isoform 1: Endoplasmic reticulum. Isoform 2: Endoplasmic reticulum . Isoform 4: Cytoplasm. Isoform 5: Cytoplasm. Isoform 7: Cytoplasm: O95278
Total number of polymer chains	4
Total formula weight	85311.22
Authors	Sankhala, R.S.,Koksal, A.C.,Cingolani, G. (deposition date: 2014-08-13, release date: 2014-12-31, Last modification date: 2023-09-20)
Primary citation	Sankhala, R.S.,Koksal, A.C.,Ho, L.,Nitschke, F.,Minassian, B.A.,Cingolani, G. Dimeric quaternary structure of human laforin. J.Biol.Chem., 290:4552-4559, 2015 Cited by PubMed: 25538239 DOI: 10.1074/jbc.M114.627406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation