Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
7T4W
DownloadVisualize
BU of 7t4w by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
Descriptor: (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1
Authors:Zebisch, M, Silvestre, L, Fischmann, T.O.
Deposit date:2021-12-10
Release date:2023-06-14
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
7T4V
DownloadVisualize
BU of 7t4v by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
Descriptor: 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1
Authors:Zebisch, M, Silvestre, L, Fischmann, T.O.
Deposit date:2021-12-10
Release date:2023-06-14
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
7T4U
DownloadVisualize
BU of 7t4u by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
Descriptor: 3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic acid, cGMP-dependent protein kinase 1
Authors:Zebisch, M, Silvestre, L, Fischmann, T.O.
Deposit date:2021-12-10
Release date:2023-06-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
7T4T
DownloadVisualize
BU of 7t4t by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Zebisch, M, Silvestre, L, Fischmann, T.O.
Deposit date:2021-12-10
Release date:2023-06-14
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
6MUL
DownloadVisualize
BU of 6mul by Molmil
Murine PI3K delta kinsae domain - cpd 1
Descriptor: 1-{1-[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]piperidin-4-yl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:Fischmann, T.O.
Deposit date:2018-10-23
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structure Overhaul Affords a Potent Purine PI3K delta Inhibitor with Improved Tolerability.
J.Med.Chem., 62, 2019
6MUM
DownloadVisualize
BU of 6mum by Molmil
Murine PI3K delta kinsae domain - cpd 3
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, [(3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidin-1-yl](oxan-4-yl)methanone
Authors:Fischmann, T.O.
Deposit date:2018-10-23
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Structure Overhaul Affords a Potent Purine PI3K delta Inhibitor with Improved Tolerability.
J.Med.Chem., 62, 2019
5KX8
DownloadVisualize
BU of 5kx8 by Molmil
Irak4-inhibitor co-structure
Descriptor: Interleukin-1 receptor-associated kinase 4, ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide
Authors:Fischmann, T.O.
Deposit date:2016-07-20
Release date:2016-08-17
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.671 Å)
Cite:Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5KX7
DownloadVisualize
BU of 5kx7 by Molmil
Irak4-inhibitor co-structure
Descriptor: Interleukin-1 receptor-associated kinase 4, ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide
Authors:Fischmann, T.O.
Deposit date:2016-07-20
Release date:2016-08-17
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5ENZ
DownloadVisualize
BU of 5enz by Molmil
S. aureus MnaA-UDP co-structure
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Fischmann, T.O.
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.
Plos Pathog., 12, 2016
9C5P
DownloadVisualize
BU of 9c5p by Molmil
Inhibitor bound VIM1
Descriptor: (2M)-4-(piperidine-4-sulfonyl)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, MAGNESIUM ION, Metallo-beta-lactamase type 2, ...
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2024-06-06
Release date:2024-10-16
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Discovery of sulfone containing metallo-beta-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues
BMCL, 2024
7SSB
DownloadVisualize
BU of 7ssb by Molmil
Co-structure of PKG1 regulatory domain with compound 33
Descriptor: 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid, cGMP-dependent protein kinase 1
Authors:Fischmann, T.O.
Deposit date:2021-11-10
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1 alpha.
J.Med.Chem., 65, 2022
7UYA
DownloadVisualize
BU of 7uya by Molmil
Inhibitor bound VIM1
Descriptor: (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYD
DownloadVisualize
BU of 7uyd by Molmil
Inhibitor bound VIM1
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ...
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYB
DownloadVisualize
BU of 7uyb by Molmil
Inhibitor bound VIM1
Descriptor: (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYC
DownloadVisualize
BU of 7uyc by Molmil
Inhibitor bound VIM1
Descriptor: (2P)-4'-(piperidin-4-yl)-4-[(piperidin-4-yl)methyl]-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, MAGNESIUM ION, ...
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
3PA4
DownloadVisualize
BU of 3pa4 by Molmil
X-ray crystal structure of compound 2a bound to human CHK1 kinase domain
Descriptor: 2-(4-chlorophenyl)-4-[(3S)-piperidin-3-ylamino]thieno[3,2-c]pyridine-7-carboxamide, GLYCEROL, Serine/threonine-protein kinase Chk1
Authors:Fischmann, T.O.
Deposit date:2010-10-18
Release date:2010-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3PA5
DownloadVisualize
BU of 3pa5 by Molmil
X-ray crystal structure of compound 1 bound to human CHK1 kinase domain
Descriptor: 2-(carbamoylamino)-5-(4-chlorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide, GLYCEROL, Serine/threonine-protein kinase Chk1
Authors:Fischmann, T.O.
Deposit date:2010-10-18
Release date:2010-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3PA3
DownloadVisualize
BU of 3pa3 by Molmil
X-ray crystal structure of compound 70 bound to human CHK1 kinase domain
Descriptor: 2-(4-chlorophenyl)-4-[(3S)-piperidin-3-ylamino]thieno[2,3-d]pyridazine-7-carboxamide, Serine/threonine-protein kinase Chk1
Authors:Fischmann, T.O.
Deposit date:2010-10-18
Release date:2010-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
2O8M
DownloadVisualize
BU of 2o8m by Molmil
Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease
Descriptor: Protease, SODIUM ION, ZINC ION
Authors:Fischmann, T.O, Prongay, A.J, Madison, V.M, Yao, N.
Deposit date:2006-12-12
Release date:2007-10-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization
J.Med.Chem., 50, 2007
5FBN
DownloadVisualize
BU of 5fbn by Molmil
BTK kinase domain with inhibitor 1
Descriptor: 1,2-ETHANEDIOL, 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, 4-[8-azanyl-3-[(3~{R})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide, ...
Authors:Raaijmakers, H.C.A, Vu-Pham, D.
Deposit date:2015-12-14
Release date:2016-02-03
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
Acs Med.Chem.Lett., 7, 2016
7UP2
DownloadVisualize
BU of 7up2 by Molmil
NDM1-inhibitor co-structure
Descriptor: (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UP1
DownloadVisualize
BU of 7up1 by Molmil
NDM1-inhibitor co-structure
Descriptor: (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, CADMIUM ION, Metallo beta-lactamase, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UP3
DownloadVisualize
BU of 7up3 by Molmil
NDM1-inhibitor co-structure
Descriptor: (3P)-4-[4-(hydroxymethyl)phenyl]-3-(2H-tetrazol-5-yl)pyridine-2-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UOX
DownloadVisualize
BU of 7uox by Molmil
NDM1-inhibitor co-structure
Descriptor: (2M)-4'-(hydroxymethyl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-ol, ACETATE ION, CADMIUM ION, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UOY
DownloadVisualize
BU of 7uoy by Molmil
NDM1-inhibitor co-structure
Descriptor: (6P)-4-amino-6-(2H-tetrazol-5-yl)benzene-1,3-disulfonamide, CADMIUM ION, Metallo beta-lactamase, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022

226262

PDB entries from 2024-10-16

PDB statisticsPDBj update infoContact PDBjnumon