5KX8

Irak4-inhibitor co-structure

Summary for 5KX8

• Entry DOI: 10.2210/pdb5kx8/pdb
• Related: 5KX7
• Descriptor: Interleukin-1 receptor-associated kinase 4, ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
• Functional Keywords: kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q9NWZ3
• Total number of polymer chains: 4
• Total formula weight: 137302.30

Authors

Fischmann, T.O. (deposition date: 2016-07-20, release date: 2016-08-17, Last modification date: 2016-08-24)

• Primary citation: Hanisak, J.,Seganish, W.M.,McElroy, W.T.,Tang, H.,Zhang, R.,Tsui, H.C.,Fischmann, T.,Tulshian, D.,Tata, J.,Sondey, C.,Devito, K.,Fossetta, J.,Garlisi, C.G.,Lundell, D.,Niu, X.; Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.; Bioorg.Med.Chem.Lett., 26:4250-4255, 2016; PubMed: 27476420; DOI: 10.1016/j.bmcl.2016.07.048

Experimental method

X-RAY DIFFRACTION (2.671 Å)